A controlled double-blind study comparing binedaline and imipramine in the treatment of endogenous depression. 50 hospitalized endogenously depressed patients (age 20-60 years, HAM-D greater than or equal to 18) were treated daily with 3 X 50 mg imipramine or 3 X 100 mg binedaline. Clinical and laboratory assessments were done before and on days 1, 3, 5, 15 and 30 of treatment. Mean Hamilton and Zung scores were statistically significant lower on day 30 when compared with pretreatment scores. No psychiatric, clinical or statistical differences were noted between the two groups. The efficacy of the clinical global impression scale was slightly higher in the binedaline groups. Frequency of side effects (specially anticholinergic) was lower in the binedaline group. binedaline is equally
Acute effects on psychomotor performance of binedaline alone and with alcohol. The effects of single oral doses of binedaline (100 mg), imipramine (50 mg) and placebo administered without and with alcohol (0.8 g/kg) were compared on performance tasks (posturographic recordings, i.e., body sway to study alertness, squares test to explore attention and concentration) and subjective assessments in 12 healthy volunteers. The tasks were completed 1.4 and 8 h after drug administration. Blood samples were collected at the same times. Binedaline had no significant effects on any of the task parameters and did not interact with alcohol. Imipramine alone impaired performance at 4 h as shown on posturographic parameters. These disturbances were potentiated by the intake of alcohol
Human cognitive function following binedaline (50 mg and 100 mg) and imipramine (75 mg): results with a new battery on tests. The effects of two single oral doses of binedaline (50 and 100 mg), imipramine (75 mg) and placebo were compared on a range of psychological tasks (logical reasoning, the Stroop test, and five-choice serial reaction) in healthy young volunteers. The tasks, together with a mood adjective check-list, were completed prior to drug administration and 1, 2, 4 and 8 h post-dose. Binedaline had no significant effect on any of the task parameters. Imipramine impaired performance on all but the Stroop test at 2 h after drug administration. At 1, 2 and 4 h, ratings on the "deactivation" dimension of the mood adjective check-list were significantly higher following imipramine