"Diffuse large B-cell lymphoma"

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                            Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after 2 or more systemic treatments Loncastuximab tesirine for treating relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma after 2 or more systemic treatments Technology appraisal guidance Published: 31 January 2024 www.nice.org.uk/guidance/ta947 /terms-and-conditions#notice-of-rights).Page 3 of211 Recommendations 1.1 Loncastuximab tesirine is recommended as an option for treating relapsed or refractory diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL) after 2 or more systemic treatments in adults, only if: • they have previously had polatuzumab vedotin, or if polatuzumab vedotin is contraindicated or not tolerated
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                            Epcoritamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments Epcoritamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments Technology appraisal guidance Published: 6 March 2024 www.nice.org.uk/guidance/ta954 © NICE 2024. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk diffuse large B-cell lymphoma after 2 ormore systemic treatments (TA954)© NICE 2024. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of-rights).Page 2 of33Contents 1 Recommendations .................................................................................................................4 2 Information about epcoritamab
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                            Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies (terminated appraisal) Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic therapies (terminated appraisal) Technology appraisal guidance Published: 29 November 2023 www.nice.org.uk/guidance/ta933 © NICE 2023. All rights Tisagenlecleucel for treating relapsed or refractory diffuse large B-cell lymphoma after 2or more systemic therapies (terminated appraisal) (TA933)© NICE 2023. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of-rights).Page 2of 4This guidance replaces TA567. Advice NICE is unable to make a recommendation about the use in the NHS of tisagenlecleucel
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                            Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphoma Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphoma Technology appraisal guidance Published: 1 March 2023 www.nice.org.uk/guidance/ta874 © NICE 2023. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of-rights).Your responsibility of opportunity and to reduce health inequalities. Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible. Polatuzumab vedotin in combination for untreated diffuse large B-cell lymphoma (TA874)© NICE 2023. All rights reserved. Subject to Notice
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                            Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinal large B-cell lymphoma after 2 or more systemic therapies Technology appraisal guidance Published: 28 February 2023 www.nice.org.uk/guidance/ta872 © NICE 2023 recommendations wherever possible. Axicabtagene ciloleucel for treating diffuse large B-cell lymphoma and primary mediastinallarge B-cell lymphoma after 2 or more systemic therapies (TA872)© NICE 2023. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of-rights).Page 2 of21Contents 1 Recommendation
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                            Axicabtagene ciloleucel for treating relapsed or refractory diffuse large B-cell lymphoma after first-line chemoimmunotherapy Axicabtagene ciloleucel for treating relapsed or refractory diffuse large B-cell lymphoma after first-line chemoimmunotherapy Technology appraisal guidance Published: 7 June 2023 www.nice.org.uk/guidance/ta895 © NICE 2023. All rights reserved. Subject to Notice of rights about axicabtagene ciloleucel Marketing authorisation indication 2.1 Axicabtagene ciloleucel (Yescarta, Kite) is indicated for 'the treatment of adult patients with diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma (HGBL) that relapses within 12 months from completion of, or is refractory to, first-line chemoimmunotherapy'. Dosage in the marketing authorisation 2.2 The dosage
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                            Tafasitamab with lenalidomide for treating relapsed or refractory diffuse large B-cell lymphoma Tafasitamab with lenalidomide for treating relapsed or refractory diffuse large B-cell lymphoma Technology appraisal guidance Published: 3 May 2023 www.nice.org.uk/guidance/ta883 © NICE 2023. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of-rights they and their NHS clinician consider it appropriate to stop. Why the committee made these recommendations People with relapsed or refractory diffuse large B-cell lymphoma who cannot have an autologous stem cell transplant usually have polatuzumab vedotin plus rituximab and bendamustine. The clinical evidence is from a small study that did not directly compare tafasitamab plus lenalidomide with any other treatment
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                            Glofitamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments Glofitamab for treating relapsed or refractory diffuse large B-cell lymphoma after 2 or more systemic treatments Technology appraisal guidance Published: 17 October 2023 www.nice.org.uk/guidance/ta927 © NICE 2023. All rights reserved. Subject to Notice of rights (https diffuse large B-cell lymphoma after 2 ormore systemic treatments (TA927)© NICE 2023. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and-conditions#notice-of-rights).Page 2 of22Contents 1 Recommendations .................................................................................................................4 2 Information about glofitamab
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                            2023Institute for Quality and Efficiency in Healthcare (IQWiG)
                            Review Analysis
                            Appears Promising
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                            Axicabtagene ciloleucel (diffuse large B-cell lymphoma, second line) ' Benefit assessment according to '35a Social Code Book V 1 Translation of Sections I 1 to I 6 of the dossier assessment Axicabtagen-Ciloleucel (DLBCL und HGBL, Zweitlinie) – Nutzenbewertung gemäß § 35a SGB V. Please note: This translation is provided as a service by IQWiG to English-language readers. However, solely the German Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (Association of the Scientific Medical Societies) CD cluster of differentiation CR complete response CTCAE Common Terminology Criteria for Adverse Events DLBCL diffuse large B-cell lymphoma ECOG PS Eastern Cooperative Oncology Group Performance Status EFS event-free survival EMA European Medicines Agency EORTC QLQ-C30 European Organisation
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                            2025CADTH - Reimbursement Review
                            Review Analysis
                            Appears Promising
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                            Lisocabtagene Maraleucel (Breyanzi) - For the treatment of adult patients with diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), primary mediastinal large B-cell lymphoma (PMBCL), high-grade B-cell lymphoma (HGBCL), and DLBCL arising f View of Lisocabtagene Maraleucel (Breyanzi) | Canadian Journal of Health Technologies Return to Article DetailsLisocabtagene Maraleucel
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                            2025Appropriate Care Guides, Agency for Care Effectiveness (Singapore)
                            Review Analysis
                            Not Yet Assessed
                            Glofitamab for relapsed or refractory diffuse large B-cell lymphoma after two or more lines of systemic therapy Published: 17 February 2025 Driving Better Decision-Making in Healthcare Page 1 Glofitamab for relapsed or refractory diffuse large B-cell lymphoma after two or more lines of systemic therapy Technology Guidance from the MOH Drug Advisory Committee Guidance Recommendations The Ministry of Health’s Drug Advisory Committee has not recommended glofitamab for inclusion on the MOH List of Subsidised Drugs for treating relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy. The decision was based on uncertain clinical effectiveness and unfavourable cost effectiveness of glofitamab compared with relevant comparators, and the unacceptable price
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                            2025NIHR Innovation Observatory
                            Tafasitamab with lenalidomide added to R-CHOP for previously untreated diffuse large B-cell lymphoma 25 FEBRUARY 2025 Tafasitamab with lenalidomide added to R-CHOP for previously untreated diffuse large B-cell lymphoma Tafasitamab with lenalidomide, added to R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), is currently in clinical development for the treatment ofpreviously untreated, high-intermediate, and high-risk patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). DLBCL is a type of blood cancer that develops when whiteblood cells, called lymphocytes, grow out of control. The affected lymphocytes lose their infection-fighting ability making the body more susceptible to infection. The first symptom ofDLBCL is often a painful swelling in the neck
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                            2023FDA - Drug Approval Package
                            Epcoritamab bysp (Epkinly) - To treat relapsed or refractory diffuse large B-cell lymphoma and high-grade B-cell lymphoma Skip to main contentSkip to FDA SearchSkip to footer links An official website of the United States government Here's how you know U.S. Food and Drug Administration  Search   MenuSearch FDASubmit search Home Drugs Drug Approvals and Databases Drugs@FDADrug Approval Package
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                            2023European Medicines Agency - EPARs
                            Glofitamab (Columvi) - diffuse large B-cell lymphoma (DLBCL) Official address Domenico Scarlattilaan 6 ● 1083 HS Amsterdam ● The Netherlands An agency of the European Union Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 © European Medicines Agency, 2023. Reproduction is authorised provided the source is acknowledged. EMA/249919/2023 EMEA/H/C/005751 Columvi (glofitamab) An overview of Columvi and why it is authorised in the EU What is Columvi and what is it used for? Columvi is a cancer medicine used to treat adults with a blood cancer called diffuse large B-cell lymphoma (DLBCL) whose cancer has returned (relapsed) or stopped responding (refractory) after at least two
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                            2023FDA - Drug Approval Package
                            Glofitamab gxbm (Columvi) - To treat diffuse large B-cell lymphoma Skip to main contentSkip to FDA SearchSkip to footer links An official website of the United States government Here's how you know U.S. Food and Drug Administration  Search   MenuSearch FDASubmit search Home Drugs Drug Approvals and Databases Drugs@FDADrug Approval Package: COLUMVIShareTweetLinkedinEmailPrintCompany: Genentech
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                            2023European Medicines Agency - EPARs
                            Epcoritamab (Tepkinly) - diffuse large B-cell lymphoma (DLBCL) Official address Domenico Scarlattilaan 6 ● 1083 HS Amsterdam ● The Netherlands An agency of the European Union Address for visits and deliveries Refer to www.ema.europa.eu/how-to-find-us Send us a question Go to www.ema.europa.eu/contact Telephone +31 (0)88 781 6000 © European Medicines Agency, 2023. Reproduction is authorised provided the source is acknowledged. EMA/372943/2023 EMEA/H/C/005985 Tepkinly (epcoritamab) An overview of Tepkinly and why it is authorised in the EU What is Tepkinly and what is it used for? Tepkinly is a cancer medicine used to treat adults with a blood cancer called diffuse large B-cell lymphoma (DLBCL) whose cancer has returned (relapsed) or stopped responding (refractory) after at least
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                            2024Austrian Institute of Health Technology Assessment
                            Review Analysis
                            Appears Promising
                            ?
                            Odronextamab (Ordspono) as monotherapy for the treatment of relapsed or refractory follicular lymphoma (r/r FL) or diffuse large B?cell lymphoma (r/r DLBCL) Odronextamab (Ordspono®) as monotherapy for the treatment of relapsed or refractory follicular lymphoma (r/r FL) or diffuse large Bcell lymphoma (r/r DLBCL) - Repository of AIHTA GmbH English | Deutsch Atom RSS 1.0 RSS 2.0 * Simple search * Advanced search * Help * Services * Login * Browse * Type * Subject * Author / Editor * Institution * Year AIHTA - Publications - Search - Odronextamab (Ordspono®) as monotherapy for the treatment of relapsed or refractory follicular lymphoma (r/r FL) or diffuse large Bcell lymphoma (r/r DLBCL) Rothschedl, E. and Grössmann, N.(2024):Odronextamab (Ordspono®) as monotherapy for the treatment of relapsed
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                            2024Council for Choices in Health Care HTA
                            Review Analysis
                            Appears Promising
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                            Summary of COHERE Finland's recommendation on loncastuximab tesirine in the treatment of diffuse large b-cell lymphoma or high-grade b-cell lymphoma SUMMARY 1(2) 19 December 2023 STM023:00/2023 VN/16744/2023 Council for Choices in Health Care in Finland Meritullinkatu 8, Helsinki PO Box 33, FI-00023 GOVERNMENT, FINLAND Tel. +358 295 16001 www.palveluvalikoima.fi email : palveluvalikoima.stm@gov.fi SUMMARY OF COHERE FINLAND’S RECOMMENDATION ON LONCASTUXIMAB TESIR-INE IN THE TREATMENT OF DIFFUSE LARGE B-CELL LYMPHOMA OR HIGH-GRADE B-CELL LYMPHOMA At its meeting of 19 December 2023, the Council for Choices in Health Care in Finland (CO-HERE Finland) adopted a recommendation on loncastuximab tesirine in the treatment of dif-fuse large B-cell lymphoma or high-grade B-cell lymphoma
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                            2024CADTH - Reimbursement Review
                            Review Analysis
                            Appears Promising
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                            Polatuzumab Vedotin (Polivy) - large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL) View of Polatuzumab Vedotin (Polivy) | Canadian Journal of Health TechnologiesReturn to Article DetailsPolatuzumab Vedotin (Polivy)
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                            2024CADTH - Reimbursement Review
                            Review Analysis
                            Appears Promising
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                            Glofitamab (Columvi) - adult patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) Return to Article DetailsGlofitamab (Columvi)