Eosinophilia-MyalgiaSyndrome We value your privacyWe and our partners store and/or access information on a device, such as cookies and process personal data, such as unique identifiers and standard information sent by a device for personalised ads and content, ad and content measurement, and audience insights, as well as to develop and improve products. With your permission we and our partners THIS ARTICLEAetiologyPresentationInvestigationsManagementComplicationsPrognosisCurrent recommendations for use of tryptophan and 5-hydroxy-L-tryptophanRelated condition: toxic oil syndrome Eosinophilia-myalgiasyndrome (EMS) is a rare condition. It was first described in 1989 after three patients in New Mexico were found to have an illness with marked myalgia and eosinophilia. They had all taken preparations containing L-tryptophan (L-TRP). An epidemic illness then became evident
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with antidepressants (such as SSRIs), MAO inhibitors or St. John's wort may result in a risk of interaction in the form of serotonin syndrome. In the past, so-called eosinophilia-myalgiasyndrome (EMS) has occurred after taking individual tryptophan-containing products. EMS can lead to severe muscle pain, skin changes, cramps, fever and damage to the heart and lungs. 5-HTP is closely related to the natural amino