presentation to the ED, and were being evaluated for serious infection. We used the same exclusion criteria as the original Pediatric Emergency Care Applied Research Network study but further excluded those who were ill-appearing (Yale Observation Score > 10). Serious infections included any of the following: urinary tract infection, bacteremia, bacterial or herpesmeningitis, bacterial pneumonia with temperatures lower than 38.2°C who were tested, 67 (5.8%) had a urinary tract infection, 10 (0.8%) had bacteremia, 3 (0.4%) had bacterial meningitis, 3 (2.9%) had herpesmeningitis, 17 (4.5%) had bacterial pneumonia, and 2 (4.8%) had bacterial enteritis. In this study, we found that infants with temperatures lower than 38.2°C were significantly less likely to have a serious infection than those with higher
typically on torso with history of wrestling exposure) 5. Erythema Multiforme (HSV is the most common cause) 6. HSV Encephalitis 1. Contrast with HSV2 which causes HerpesMeningitis (Mollaret Meningitis) instead of Encephalitis VII. Differential Diagnosis 1. Oral Lesions 1. Aphthous Ulcers 2. Behcet Syndrome 3. Herpangina 2. Skin lesions 1. Herpes Zoster (Shingles) 2
typically on torso with history of wrestling exposure) 5. Erythema Multiforme (HSV is the most common cause) 6. HSV Encephalitis 1. Contrast with HSV2 which causes HerpesMeningitis (Mollaret Meningitis) instead of Encephalitis VII. Differential Diagnosis 1. Oral Lesions 1. Aphthous Ulcers 2. Behcet Syndrome 3. Herpangina 2. Skin lesions 1. Herpes Zoster (Shingles) 2
dependent at discharge * Infectious meningitis * Encephalitis with radiological evidence of severe cortical or severe hemispheric destruction * Silastic catheters, broviacs, or Hickman port home TPA * Infants who may not be available for the duration of the study * Any infant who in the opinion of investigator has no potential to benefit from the intervention (e.g., children with prenatal herpesmeningitis, severe cortical destruction, mother does not follow up with the intervention or with the follow-up appointments)Contacts and LocationsGo to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information Information from the National Library of Medicine To learn more about this study, you or your doctor may
of herpesmeningitis; it is thought to be caused by herpes simplex virus type 2.[31]Fungal[edit]There are a number of risk factors for fungal meningitis, including the use of immunosuppressants (such as after organ transplantation), HIV/AIDS,[32] and the loss of immunity associated with aging.[33] It is uncommon in those with a normal immune system[34] but has occurred with medication contamination.[35
of the GEN-003-002 study. 3. History of any form of ocular Herpes Simplex Virus (HSV) infection, HSV-related erythema multiforme, or herpesmeningitis or encephalitis. 4. Immunocompromised individuals, including those receiving immunosuppressive doses of corticosteroids (more than 20 mg of prednisone given daily or on alternative days for 2 weeks or more within 6 months prior to the first dose of Study
of ocular HSV infection, HSV-related erythema multiforme, or herpesmeningitis or encephalitis * Immunocompromised individuals * Use of corticosteroids within 30 days of starting the study and during the study or other immunosuppressive agents * Presence or history of autoimmune disease regardless of current treatment * Current infection with HIV or hepatitis B or C virus * History of hypersensitivity
. * Pregnant or nursing women. * Receipt of any investigational drug within 30 days of the first scheduled day of immunization. * History of hypersensitivity to any component of the vaccine. * History of genital HSV-1 infection. * History of: (1) any form of ocular HSV infection, (2) HSV-related erythema multiforme, or (3) herpesmeningitis or encephalitis. * Any other condition which in the opinion
Virus type-1 (HSV-1) infection. * History of any form of ocular Herpes Simplex Virus (HSV) infection, HSV-related erythema multiforme, or herpesmeningitis or encephalitis. * Immunocompromised individuals, including those receiving immunosuppressive doses of corticosteroids (more than 20 mg of prednisone given daily or on alternative days for 2 weeks or more within 6 months prior to the first dose
), varicella zoster virus (known for causing chickenpox and shingles), mumps virus, HIV, and LCMV.[20] Mollaret's meningitis is a chronic recurrent form of herpesmeningitis; it is thought to be caused by herpes simplex virus type 2.There are a number of risk factors for fungal meningitis, including the use of immunosuppressants (such as after organ transplantation), HIV/AIDS, and the loss of immunity
erythema multiforme, or herpesmeningitis or encephalitis * Immunocompromised individuals * Diagnosis or suspicion of an AESI * Diagnosis or suspicion of any other autoimmune disease not listed in Appendix 4 of the protocol * Vaccine-related SAE in GEN-003-003 * Known current infection with HIV or hepatitis B or C virus * History of hypersensitivity to any component of the vaccine * Prior receipt