"Cerebrospinal fluid" from_date:2012

Endovascular Therapy for the Treatment of Cerebrospinal Fluid Venous Fistulas Skip to main contentAboutCollaboration/OutreachPatient/CommunityCareersContactMy CADTHFRReportsResourcesProvide InputSubmit a RequestNews & EventsWhat Does The Evidence Say About...SearchBreadcrumbHome Endovascular Therapy for the Treatment of Cerebrospinal Fluid Venous FistulasCopied to clipboardEndovascular Therapy for the Treatment of Cerebrospinal Fluid Venous Fistulas( Last Updated : November 14, 2022)Project Status:CompletedProject Line:Reference ListProject Sub Line:Summary of AbstractsProject Number:RB1642-000Effective finish date:November 16, 2022DetailsQuestionWhat is the clinical effectiveness of endovascular therapy for the treatment of patients with cerebrospinal fluid venous fistulas compared to other surgical

Epidural Blood Patch with Fibrin Glue for Cerebrospinal Fluid Leak Skip to main contentAboutCollaboration/OutreachPatient/CommunityCareersContactMy CADTHFRReportsResourcesProvide InputSubmit a RequestNews & EventsWhat Does The Evidence Say About...SearchBreadcrumbHome Epidural Blood Patch with Fibrin Glue for Cerebrospinal Fluid LeakCopied to clipboardEpidural Blood Patch with Fibrin Glue for Cerebrospinal Fluid Leak( Last Updated : November 8, 2022)Project Status:CompletedProject Line:Reference ListProject Sub Line:Summary of AbstractsProject Number:RB1641-000Effective finish date:November 14, 2022DetailsQuestionWhat is the clinical effectiveness of the use of an epidural blood patch with fibrin glue for patients experiencing cerebrospinal fluid leaks?What is the cost-effectiveness of the use

Digital Subtraction Myelography for Cerebrospinal Fluid Leak Identification Skip to main contentAboutCollaboration/OutreachPatient/CommunityCareersContactMy CADTHFRReportsResourcesProvide InputSubmit a RequestNews & EventsWhat Does The Evidence Say About...SearchBreadcrumbHome Digital Subtraction Myelography for Cerebrospinal Fluid Leak IdentificationCopied to clipboardDigital Subtraction Myelography for Cerebrospinal Fluid Leak Identification( Last Updated : November 23, 2022)Project Status:CompletedProject Line:Reference ListProject Sub Line:Summary of AbstractsProject Number:RB1643-000Effective finish date:November 22, 2022DetailsQuestionWhat is the diagnostic test accuracy of digital subtraction myelography for the identification of patients with cerebrospinal fluid leaks?Key MessageWe

Detection of Aquaporin-4 (AQP4) antibodies in serum of cerebrospinal fluid for diagnosis of Neuromyelitis optica (NMO) 1 Public Summary Document Application No. 1582 – Detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein antibody (MOG) antibodies for diagnosis of neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein antibody-related demyelination (MARD one test after another. MSAC noted that the tests are already being done under a generic antibody-testing MBS item number. This application was for a specific MBS item number that has a more appropriate fee. The antibody test can be done on blood (serum) or cerebrospinal fluid (CSF). MSAC recommended doing the test on serum only, as CSF is more difficult to get (it involves putting a needle

Ubiquity of Synthetic Phenolic Antioxidants in Children's Cerebrospinal Fluid from South China: First Evidence for Their Penetration across the Blood-Cerebrospinal Fluid Barrier. Synthetic phenolic antioxidants (SPAs) and relevant transformation products (TPs) are potentially neurotoxic pollutants to which humans are widely exposed. However, their penetration behavior across the brain barrier and associated exposure to the central nervous system (CNS) remain unknown. This study is the first to investigate a wide range of 30 SPAs and TPs, including emerging SPAs, in matched serum and cerebrospinal fluid (CSF) samples from children in Guangzhou, China. Sixty-two children of either sex aged <14 years with nonbloody CSF and complete clinical information were included. The findings demonstrated

Pharmacometabolomics in TB meningitis-Understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid. Poor penetration of many anti-tuberculosis (TB) antibiotics into the central nervous system (CNS) is thought to be a major driver of morbidity and mortality in TB meningitis (TBM). While the amount of a particular drug that crosses into the cerebrospinal fluid (CSF) varies from person to person, little is known about the host factors associated with interindividual differences in CSF concentrations of anti-TB drugs. In patients diagnosed with TBM from the country of Georgia (n = 17), we investigate the association between CSF concentrations of anti-TB antibiotics and multiple host factors including serum drug

Characterizing plasma and cerebrospinal fluid biomarkers relevant to neurodegeneration in captive olive baboons (Papio anubis). Alzheimer's disease and related dementias (ADRD) present a significant global disease burden that is only expected to grow in the future. As such, there is a need to develop and investigate biomarkers that identify individuals at risk of developing ADRD with the goal , to our knowledge, there are no data characterizing fluid biomarkers relevant to neurodegeneration or ADRD in baboons. We collected plasma (N = 139) and cerebrospinal fluid (CSF, N = 44) from captive baboons ranging in age from 3-19 years old. We characterized biomarkers as a function of age, sex, and rearing status in baboons using a bead-based bioplex human assay (Thermo Fisher Scientific's

Neurologic manifestations of COVID-19 and viral test in cerebrospinal fluid. Neurological manifestations are present in about one-third of COVID-19 cases, ranging from mild symptoms, such as anosmia, to more severe forms like demyelinating syndromes. Although direct invasion of the CNS has been demonstrated, the immune- mediated pathway is also described and more accepted. Even in cases where

Cytochemical analysis of cerebrospinal fluid in tuberculous meningitis versus other etiologies. Meningeal tuberculosis (TBM) is the most severe form of extrapulmonary tuberculosis due to its high mortality and long-term sequelae in survivors. A cross-sectional study of diagnostic tests was carried out in a private clinical laboratory in Lima, Peru. All cerebrospinal fluid (CSF) samples from

Incidence, pathogens and antimicrobial resistance of blood and cerebrospinal fluid isolates from a tertiary neonatal unit in South Africa: A 10 year retrospective review. To determine trends in incidence, etiology and antimicrobial susceptibility of blood and cerebrospinal fluid (CSF) culture confirmed infections in hospitalized infants in a large tertiary neonatal unit in South Africa. Single

Pediatric hydrocephalus - Management of cerebrospinal fluid shunt infection 8. Management of cerebrospinal fluid shunt infection - cns.org Log InCreate an Account Nidus Wellness and Resilience Residents Foundation DirectoryJoin CNS Nidus Wellness and Resilience Residents Foundation Directory * Meetings * Meetings Overview * 2022 Annual Meeting * 2021 Annual Meeting * Claim CME text of the guideline was edited to reflect the update. Please clickherefor the original publication.) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines Part 8: Management of cerebrospinal fluid shunt infection UPDATE Mandeep S. Tamber, MD,1 Paul Klimo, Jr., MD, MPH,2,3 Catherine A. Mazzola, MD,4 Ann Marie Flannery, MD5 1Department of Pediatric

Pediatric hydrocephalus - Effect of valve type on cerebrospinal fluid shunt efficacy 5. Effect of valve type on cerebrospinal fluid shunt efficacy - cns.org Log InCreate an Account Nidus Wellness and Resilience Residents Foundation DirectoryJoin CNS Nidus Wellness and Resilience Residents Foundation Directory * Meetings * Meetings Overview * 2022 Annual Meeting * 2021 Annual Meeting Neurosurg Pediatrics (Suppl) 14:35–43, 2014 AANS, 2014 (Original text of the guideline was edited to reflect the update. Please clickherefor the original publication.) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines Part 5: Effect of valve type on cerebrospinal fluid shunt efficacy UPDATE Lissa C. Baird, MD,1Catherine A. Mazzola, MD,2Kurtis I Auguste, MD

Pediatric hydrocephalus - Cerebrospinal fluid shunt or endoscopic third ventriculostomy for the treatment of hydrocephalus in children 4. Cerebrospinal fluid shunt or endoscopic third ventriculostomy for the treatment of hydrocephalus in children - cns.org Log InCreate an Account Nidus Wellness and Resilience Residents Foundation DirectoryJoin CNS Nidus Wellness and Resilience Residents Societies * Reposted with permission from ©AANS, 2014 J Neurosurg Pediatrics (Suppl) 14:30–34, 2014 AANS, 2014 (Original text of the guideline was edited to reflect the update. Please clickherefor the original publication.) Pediatric hydrocephalus: systematic literature review and evidence-based guidelines Part 4: Cerebrospinal fluid shunt or endoscopic third ventriculostomy

A search for bacteria identified from cerebrospinal fluid shunt infections in previous surgical events. Shunt infections are a common complication when treating hydrocephalus by cerebrospinal fluid (CSF) shunt placement. The source of infecting pathogens is not well understood. One hypothesis, which we explored here, is that microorganisms persist chronically in the host long before a symptomatic

Targeted metabolomics investigation of metabolic markers of Mycobacterium tuberculosis in the cerebrospinal fluid of paediatric patients with tuberculous meningitis. To investigate metabolic markers linked to Mycobacterium tuberculosis (M. tb) in the cerebrospinal fluid (CSF) of a South African cohort of paediatric tuberculous meningitis (TBM). Targeted proton magnetic resonance (1H-NMR

SecurAcath for securing cerebrospinal fluid catheters SecurAcath for securing cerebrospinal fluid catheters Medtech innovation briefing Published: 5 June 2017 www.nice.org.uk/guidance/mib107 pathwaysSummary Summary • The technologytechnology and indication described in this briefing is SecurAcath for securing cerebrospinal fluid drainage catheters. The device uses a small metal 'anchor' that sits below the skin and holds the catheter in place. • The innovative aspectinnovative aspect is that this is the only securement device available for cerebrospinal fluid catheters that aims to reduce the risk of accidental dislocation or removal of the catheter. • The intended place in therapyplace in therapy would be as an alternative to current methods of securing cerebrospinal fluid catheters

A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations. Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the pathophysiology of neurologic diseases has produced only a preliminary characterization of CSF immune cells. CSF derives from and borders central nervous system (CNS) tissue, allowing for comprehensive

Differential impact of lymphatic outflow pathways on cerebrospinal fluid homeostasis. Dysfunctional lymphatic drainage from the central nervous system (CNS) has been linked to neuroinflammatory and neurodegenerative disorders, but our understanding of the lymphatic contribution to CNS fluid autoregulation remains limited. Here, we studied forces that drive the outflow of the cerebrospinal fluid

Low-Pass Whole Genome Sequencing of Cell-Free DNA from Cerebrospinal Fluid: A Focus on Pediatric Central Nervous System Tumors. Cell-free DNA (cfDNA) technology has allowed for cerebrospinal fluid (CSF), a previously underutilized biofluid, to be analyzed in new ways. The interrogation of CSF-derived cfDNA is giving rise to novel molecular insights, particularly in pediatric central nervous

Lecanemab-Associated Amyloid-β Protofibril in Cerebrospinal Fluid Correlates with Biomarkers of Neurodegeneration in Alzheimer's Disease. The Clarity AD phase III trial showed that lecanemab reduced amyloid markers in early Alzheimer's disease (AD) and resulted in less decline on measures of cognition and function than placebo. Herein, we aimed to characterize amyloid-β (Aβ) protofibril (PF ) captured by lecanemab in human cerebrospinal fluid (CSF) from living participants with different stages in AD, which enable an enhanced understanding of the dynamic changes of lecanemab-associated Aβ-PF (Lec-PF) in vivo. We newly developed a unique and highly sensitive immunoassay method using lecanemab that selectively captures Lec-PF. The CSF level of Lec-PF, Aβ42, Aβ40, p-tau181, p-tau 217, total tau