"Estrogenic substances" from_date:2012

for the formation of estrone (a weakestrogen) and estradiol (a more potent estrogen and the predom-inant estrogen in premenopausal and perimenopausal women).Synthetic CE is a blend of synthetic estrogen substances includ-ing estrone sulfate, equilin sulfate, and estradiol sulfate. Pre-scription formulations of micronized 17β-estradiol are identicalto the structure of estradiol that is produced by the ovaries. Es

6.5 of the SmPC. Assessment report EMA/CHMP/383987/2014 Page 15/153 2.2.2. Active Substance Conjugated Oestrogens General information The “active substance” Conjugated Oestrogens is a mixture of different estrogenic substances isolated from pregnant mare’s urine. Conjugated oestrogens is a known entity which is monographed in the European Pharmacopoeia. The main components are estrone in water. Since CEDL comprises a mixture of active estrogenic substances isolated from natural sources, extensive information on its physical characteristics is not available. The components of the conjugated oestrogens have several stereocenters. The manufacturing process only consists of extraction of the conjugated oestrogens from urine and mixing with excipients

these studies were difficult to interpret due to the effects on body weight, which interacted with effects on bone parameters: OVX rats gain weight faster than sham-controls, which results in stronger bones due to higher body weight load. The decrease of body weight gain caused by Ospemifene treatment, consistent with growth inhibition caused by estrogenic substances, results in weaker bones. Nevertheless it was established that Ospemifene decreased ovariectomy-induced trabecular bone loss. Cortical bone was much less affected by ovariectomy and subsequently Ospemifene effects were not as clear as in trabecular bone. In proximal femur neck, labeled surface and mineralizing surface (% of bone surface) were

Investigation into Adaptation in Genes Associated with Response to Estrogenic Pollution in Populations of Roach (Rutilus rutilus) Living in English Rivers. Exposure of male fish to estrogenic substances from wastewater treatment works (WwTWs) results in feminization and reduced reproductive fitness. Nevertheless, self-sustaining populations of roach () inhabit river stretches polluted

proteins differentially phosphorylated in the brain of fathead minnows (Pimephales promelas) aqueously exposed for 30 minutes to two HAAs, 17α-ethinylestradiol (EE2), a strong estrogenic substance, and levonorgestrel (LNG), a progestin, both components of the birth control pill. EE2 promoted differential phosphorylation of proteins involved in neuronal processes such as nervous system development

A Chip for Estrogen Receptor Action: Detection of Biomarkers Released by MCF-7 Cells through Estrogenic and Anti-Estrogenic Effects The fluorescence-based multi-analyte chip platform for the analysis of estrogenic and anti-estrogenic substances is a new in vitro tool for the high throughput screening of environmental samples. In contrast to existing tools, the chip investigates the complex action

English Estrogen, Estrogens, estrogens (medication), estrogens, oestrogen products, oestrogens, estrogen products, oestrogen, estrogen substance, estrogenic preparation, Estrogens (product), Agonists, Estrogen Receptor, Receptor Agonists, Estrogen, Estrogen Receptor Agonists, Compounds, Estrogenic, Estrogenic Compounds, Agents, Estrogenic, Estrogenic Agents, Estrogen product , Oestrogen product, Oestrogen, Estrogen (substance), Estrogenic drug, Estrogenic preparation (product), Estrogenic preparation, Oestrogenic drug, Oestrogenic preparation, estrogen, Estrogen preparation, NOS, Estrogen, NOS, Estrogenic drug, NOS, Oestrogen preparation, NOS, Oestrogen, NOS, Oestrogenic drug, NOS, Estrogenic preparation (substance), Estrogens (substance), Oestrogens, Therapeutic Estrogen

. Exposure to some compounds has been correlated with the skewing of sex ratios in aquatic species, feminization and demasculinization of male animals, declines in human sperm counts, and overall diminution in fertility of birds, fish, and mammals. We herein devote space to several classes of endocrine-disrupting compounds (EDCs), including estrogenic substances such as bisphenol A (BPA), molecules

it was reported to have estrogenic activity in a cell culture assay.Though later studies have showed that Bis-GMA does not hydrolyse into the estrogenic substance BPA, BPA has still been detected to be release out of several commercial Bis-GMA-based dental restorative materials. Although there is a lack of studies analysing the association between BPA exposure from dental materials and its adverse effects

English Estrogen, Estrogens, estrogens (medication), estrogens, oestrogen products, oestrogens, estrogen products, oestrogen, estrogen substance, estrogenic preparation, Estrogens (product), Agonists, Estrogen Receptor, Receptor Agonists, Estrogen, Estrogen Receptor Agonists, Compounds, Estrogenic, Estrogenic Compounds, Agents, Estrogenic, Estrogenic Agents, Estrogen product , Oestrogen product, Oestrogen, Estrogen (substance), Estrogenic drug, Estrogenic preparation (product), Estrogenic preparation, Oestrogenic drug, Oestrogenic preparation, estrogen, Estrogen preparation, NOS, Estrogen, NOS, Estrogenic drug, NOS, Oestrogen preparation, NOS, Oestrogen, NOS, Oestrogenic drug, NOS, Estrogenic preparation (substance), Estrogens (substance), Oestrogens, Therapeutic Estrogen

with those of only a weak estrogenic substance. These findings may help to focus studies of the most environmentally significant OSPW-related pollutants, if reproduced in a greater range of OSPW.