dermatitidis, endemic to the north central and southern US, Canada, and parts of Africa. Most commonly involves the lungs. Dissemination can occur, with extrapulmonary infection often seen in the skin, bones, joints, central nervous system, and genitourinary system. Although key epidemiological factors in the history are often suggestive of the diagnosis, histopathological or microbiological examination of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology. Lancet Infect Dis. 2021 Dec;21(12):e364-e374. Although pulmonary involvement is most common, skin, central nervous system, and osteoarticular involvement are frequently seen. Less commonly, infection can involve other sites, such as the genitourinary system, and patients can even have