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Debriefing, Wellness strategies and Humor-Training Emergency Medicine Journal Club ARCHIVES/ CLINICAL TOOLS/ RESIDENTS/ PROCEDURES/ LLSA/ EPT Debriefing, Wellness and Humor in MedicineThis month team JC is inviting everyone to join us for our first combination Journal Club/Talent Show at the Push Comedy Theatre . We will be discussing a few topics relevant to physician wellness such as approaches to critical incident debriefing, how to find and develop humor in the ED and sources of affirmation for our work or, #WhyIDoIt. We will follow these great discussions with an open mike night, so I know you’re out there and I am appealing to YOU to sign up in advance and join us for a night of comradery and hilarity. Consider singing or playing a song, tell us a story, share a few favorite jokes
immune globulin human and recombinant human hyaluronidase - HyQvia - Humoral immunodeficiency Skip to main contentAboutCollaboration/OutreachPatient/CommunityCareersContactMy CADTHFRReportsResourcesProvide InputSubmit a RequestNews & EventsWhat Does The Evidence Say About...SearchBreadcrumbHome Reimbursement Reviews immune globulin human and recombinant human hyaluronidaseCopied to clipboard ResponseGeneric Name: immune globulin human and recombinant human hyaluronidaseProject Status: CompleteTherapeutic Area: Humoral immunodeficiencyManufacturer: Takeda Canada Inc.Brand Name: HyQviaProject Line: Reimbursement ReviewProject Number: ST0695-000NOC Status at Filing: Pre NOCDetailsManufacturer Requested Reimbursement Criteria1: As replacement therapy for primaryhumoral immunodeficiency (PI
Mindfulness Interfused with Humor: Insights From a Randomized Controlled Trial of a Humor-Enriched Mindfulness-Based Program. Both mindfulness and humor are inherently connected to well-being. Recent research found evidence for their combined effect in a joint training, the Humor-Enriched Mindfulness-Based Program (HEMBP). This study extends these findings by exploring (1) effects of Mindfulness -Based Stress Reduction (MBSR) on different forms of humor, (2) differential effects of the HEMBP on outcomes compared to MBSR, and (3) whether the HEMBP and MBSR may alter worldviews. Ninety participants were randomly allocated to three conditions: the HEMBP, MBSR, and a wait-list control group. Participants' mindfulness, psychological well-being, life satisfaction, perceived stress, comic styles
Wild Florida mottled ducks demonstrate strong heterogeneity in their humoral innate immune response. The Florida Mottled Duck (Anas fulvigula fulvigula) is a unique subspecies of waterfowl whose range is limited to peninsular Florida, USA. As an endemic subspecies, Florida Mottled Ducks face numerous conservation stressors, such as habitat conversion and hybridization with non-native Mallards performed health assessments of Mottled Ducks in the Central Florida area. Specifically, we examined the humoral innate immune system, i.e., the plasma of Mottled Ducks in response to a common but extraneous pathogen: Escherichia coli strain American Type Culture Collection (ATCC) number 8739. We utilized a bactericidal assay ("bacterial killing assay" or BKA) commonly used in eco-immunology, to provide
Humor in parenting: Does it have a role? Despite the widespread use of humor in social interactions and the considerable literature on humor in multiple fields of study, the use of humor in parenting has received very little formal study. The purpose of this pilot study was to gather preliminary data on the use of humor in the raising of children. We developed and administered a 10-item survey to measure people's experiences being raised with humor and their views regarding humor as a parenting tool. Responses were aggregated into Disagree, Indeterminate, and Agree, and analyzed using standard statistical methods. Respondents (n = 312) predominantly identified as male (63.6%) and white (76.6%) and were (by selection) between the ages of 18-45 years old. The majority of participants reported
The success elements of humor use in workplace leadership: A proposed framework with cognitive and emotional competencies. This qualitative study aims to investigate the competencies and effectiveness of humor use in workplace leadership. By exploring the elements underlying successful and unsuccessful humor use, this research offers insights into the competencies required for leaders to leverage humor effectively. Adopting a qualitative inductive approach, fifteen individual semi-structured interviews were conducted, generating a dataset of 51 critical incidents of humor use. Reflexive thematic analysis was employed to identify key themes, resulting in the identification of five central elements: Reading the context, Intention and motivation, Judgement and decision, Skillful delivery
Impact of variable titer COVID-19 convalescent plasma and recipient SARS-CoV2-specific humoral immunity on survival in hospitalized patients. COVID-19 convalescent plasma (CCP) was one of the first therapies to receive emergency use authorization for management of COVID-19. We assessed the effectiveness of CCP in a propensity-matched analysis, and whether the presence of antibodies
Risk reduction in SARS-CoV-2 infection and reinfection conferred by humoral antibody levels among essential workers during Omicron predominance. The extent to which semi-quantitative antibody levels confer protection against SARS-CoV-2 infection in populations with heterogenous immune histories is unclear. Two nested case-control studies were designed within the multisite HEROES/RECOVER
Is Humor a Meaning Making Process? Investigating the Effects of Absurd Humor and Mortality Salience on Meaning in Life, Moral Identity, Belongingness, and Belief in a Just World. Both mortality salience and absurd humor have been found to elicit fluid compensation - the automatic process of strengthening unrelated beliefs in response to a meaning threat. Previous research has suggested that perceiving absurd humor to be funny decreases people's tendency to fluid compensate, suggesting that humor is a meaning-making process. However, these results may have been confounded by mortality salience effects. Furthermore, few studies have investigated the effects of absurd humor and mortality salience on multiple beliefs. In the current study, we aimed to conceptually replicate previous research
Accuracy and safety of a novel aqueous humor collector versus 29 G insulin syringe for anterior chamber paracentesis and aqueous humor collection: A multicenter randomized clinical trial.
In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics. Aqueous humor inflow rate, a key parameter influencing aqueous humor dynamics, is typically measured by fluorophotometry. Analyzing fluorophotometric data depends, inter alia, on the volume of aqueous humor in the anterior chamber but not the posterior chamber. Previous humor volume, which is very dissimilar to the situation in humans. Anterior chamber volumes in 2-month-old BALB/cAnNCrl and C57BL6/J mice were 1.55 ± 0.36 µL (n = 10) and 2.05 ± 0.25 µL (n = 10), respectively. This implies that previous studies likely overestimated the aqueous inflow rate by approximately twofold. It is necessary to reassess previously reported estimates of aqueous inflow rates
Aqueous Angiography Guided Bent Ab Interno Needle Goniectomy in High versus Low Aqueous Humor Outflow Regions in POAG: A Pilot RCT. Trabecular cutting minimally invasive glaucoma surgery like bent ab interno needle goniectomy (BANG) when performed in baseline aqueous angiography identified low aqueous humor outflow regions, results in greater success of intraocular pressure reduction. To study the efficacy of Bent Ab Interno Needle Goniectomy (BANG) in high versus low aqueous humor outflow (AHO) regions as determined by Aqueous Angiography(AA) in patients with primary open angle glaucoma (POAG). A prospective, single-centre, pilot, randomized control trial recruited 30 eyes of 30 patients of POAG and visually significant cataract (45-80 y) and were randomised into two groups ("A": BANG performed
Antigenic drift expands influenza viral escape pathways from recalled humoral immunity. Initial exposure to a rapidly evolving virus establishes B cell memory that biases later responses to antigenically drifted strains. This "immune imprinting" implies that subsequent exposure to a drifted strain can induce affinity maturation of memory B cells toward cross-reactivity with the drifted strain
Humoral and cellular immune responses after 6 months of a heterologous SARS-CoV-2 booster with the protein-based PHH-1V vaccine in a phase IIb trial. The HIPRA-HH-2 was a multicentre, randomized, active-controlled, double-blind, non-inferiority phase IIb clinical trial comparing the immunogenicity and safety of the PHH-1V adjuvanted recombinant vaccine as a heterologous booster against homologous booster with BNT162b2. Interim results demonstrated strong humoral and cellular immune response against the SARS-CoV-2 Wuhan-Hu-1 strain and the Beta, Delta, and Omicron BA.1 variants up to day 98 post-dosing. Here we report that these responses with PHH-1V are sustained up to 6 months, including in participants over 65 years, despite their smaller sample size. The PHH-1V booster was non-inferior
IL33 protects from recurrent C. difficile infection by restoration of humoral immunity. Clostridioides difficile infection (CDI) recurs in one of five patients. Monoclonal antibodies targeting the virulence factor TcdB reduce disease recurrence, suggesting that an inadequate anti-TcdB response to CDI leads to recurrence. In patients with CDI, we discovered that IL33 measured at diagnosis predicts future recurrence, leading us to test the role of IL33 signaling in the induction of humoral immunity during CDI. Using a mouse recurrence model, IL33 was demonstrated to be integral for anti-TcdB antibody production. IL33 acted via ST2+ ILC2 cells, facilitating germinal center T follicular helper (GC-Tfh) cell generation of antibodies. IL33 protection from reinfection was antibody-dependent, as mMT KO
The impact of HBsAg reduction via siRNA treatment on natural and vaccine (BRII-179)-induced HBV-specific humoral and cellular immune responses. The impact of HBsAg reduction from small interfering RNA (siRNA) treatments on HBV-specific immunity of CHB participants has not been adequately analyzed in human. We conducted a phase 2a study treating CHB participants with 9 4-weekly doses of HBV % of the participants for at least 32 weeks after combinatory treatment. Moreover, the neutralizing ability of the anti-HBs positive sera was associated with HBsAg reduction. SiRNA-induced HBsAg reduction may contribute to the persistence and efficacy of the humoral arm of HBV-specific adaptive immunity in CHB participants receiving therapeutic vaccine BRII-179.
Safety and humoral immunogenicity of the ChAdOx1 nCoV-19 vaccine administered as a fourth dose booster following two doses of ChAdOx1 nCoV-19 and a third dose of BNT162b2 (COV009): A prospective cohort study. Evaluation of the safety and humoral immunogenicity of ChAdOx1 nCoV-19 as a fourth dose booster in individuals who have had two initial doses of the vaccine and a third dose of BNT162b2 . COV009 is a safety follow-up study of volunteers enroled in the pivotal pre-licensure ChAdOx1 nCoV-19. In this sub-study, 149 eligible participants were given a fourth dose of ChAdOx1 nCoV-19. Primary outcomes were reactogenicity, safety, and humoral immunogenicity. Anti-spike IgG and pseudo-neutralising antibody against multiple variants were measured from pre-first dose to 28 days post-second
Increased aqueous humor levels of endothelin-1 in patients with open angle glaucoma. Endothelin is a potent vasoconstrictor and contributes to the regulation of vascular perfusion. Aberrant endothelin-1 (ET-1) levels in aqueous humor have been reported across a variety of vascular diseases of the eye, including glaucoma. These findings suggest that dysregulation of ET-1 production may contribute to glaucoma pathophysiology. In this study, aqueous humor from patients undergoing ocular surgery was assayed for ET-1 abundance and related to the presence of glaucoma. Open angle glaucoma patients (n=62 total) from the ophthalmology clinics of the University of Iowa Hospitals and Clinics were enrolled in this study and organized into three distinct cohorts based on their diagnostic criteria, including
Elevated Very-Long-Chain Ceramides in the Vitreous Humor of Patients With Proliferative Diabetic Retinopathy. To quantitate the levels of various ceramide species in the vitreous of patients with proliferative diabetic retinopathy (PDR) and to investigate the role of vitreal ceramides in the pathogenesis of PDR. A case control study. We collected vitreous samples from 25 type 2 diabetes patients