Astrocyte dysfunction following molybdenum-associated purine loading could initiate Parkinson’s disease with dementia Sporadic or idiopathic Parkinson's disease is a movement disorder with a worldwide distribution, a long pre-clinical latent period and a frequent association with dementia. The combination of molybdenumdeficiency and purine ingestion could explain the movement disorder , the distribution, the latent period and the dementia association. Recent studies in sheep have shown that molybdenumdeficiency enables some dietary purines to accumulate in the central nervous system. This causes astrocyte dysfunction, altered neuromodulation and eventually irreversible central nervous system disease. Humans and sheep share the ability to salvage purines and this ability places humans at risk
. Resting cells cultivated in a molybdenum-deficient medium had low nicotine transformation activity, and excess molybdenum was detected in the purified VppA by inductively coupled plasma-mass spectrometry analysis. Thus, it is demonstrated that VppA is a two-component molybdenum-containing hydroxylase.
or molybdenumdeficiency which may accompany this in children aged between 6 and 12 years in two schools in the province of Hatay (endemic goitre region). This study is a case-control field-study in which students aged between 6 and 12 years were included. One hundred fourteen subjects from the village of Tanışma related to the center of our province and 100 subjects from the city center of Hatay (Antakya
IN THIS CHAPTER Overview of Minerals Chromium Deficiency Chromium Toxicity Copper Deficiency Copper Toxicity Wilson Disease Fluorine Deficiency Fluorine Toxicity Iodine Deficiency Iodine Toxicity Iron Deficiency Iron Toxicity Manganese Deficiency Manganese Toxicity MolybdenumDeficiency Molybdenum Toxicity Selenium Deficiency Selenium Toxicity Zinc Deficiency Zinc Toxicity Zinc Deficiency By Larry E. Johnson