"Nandrolone decanoate" from_date:2012

Nandrolone decanoate safely combats catabolism in burned patients: A new potential indication after recall. The hyper-catabolic state is a devastating pathophysiological response to severe injury, infection or burns. Nandrolone decanoate (ND) is a potent anabolic steroid have many clinical indications, but not investigated in burn injuries yet. A prospective randomized control study included 40 findings and laboratory findings are correlated and highly support the use of ND in burns as new effective and safe long-lasting indication. This study results showed preservation of lean body mass and protein partition, as well as the near normal nitrogen balance in burn patients. Study proposes that nandrolone decanoate could be used in safe and effective way to combat hypercatabolic impact in burn

The non-preventive effects of human menopausal gonadotropins on ovarian tissues in Nandrolone decanoate-treated female rats: A histochemical and ultra-structural study The follicular growth and development may be affected by abused drugs. Nandrolone decanoate (ND) as an anabolic androgenic steroid can damage the morphological and functional features of the ovary and may lead to reproductive

Effects of nandrolone decanoate on expression of steroidogenic enzymes in the rat testis Nandrolone decanoate (ND) is an anabolic-androgenic steroid frequently used for clinical treatment. However, the inappropriate use of ND results in the reduction of serum testosterone level and sperm production. The suppressive effect of ND on testosterone production has not been investigated in detail

Differences of Matrix Metalloproteinase 2 Expression between Left and Right Ventricles in Response to Nandrolone Decanoate and/or Swimming Training in Mice Matrix metalloproteinase (MMP)-2 plays an important role in the remodeling of left ventricles (LVs) and right ventricles (RVs). We investigated the differences of MMP-2 expression between LV and RV in response to nandrolone decanoate (ND

The impact of nandrolone decanoate administration on ovarian and uterine tissues in rat: Luteinizing hormone profile, histopathological and morphometric assessment The study had been conducted to evaluate the effects of nandrolone decanoate (abused repeated doses) on female rat's ovary and uterus during administration and withdrawal. The study included 18 rats that were divided into control group (n = 6) and treated group (n = 12). The treated group was injected intramuscular (IM) with nandrolone decanoate (7 mg/kg body weight) for three consecutive days, for two weeks. The study stated that nandrolone decanoate increases the weights of body, ovary, and uterus. Moreover, it has a tendency of bringing upon modifications in the biochemical, histopathological, and morphological makeup

Nandrolone decanoate interferes with testosterone biosynthesis altering blood–testis barrier components The aim of this study was to investigate whether nandrolone decanoate (ND) use affects testosterone production and testicular morphology in a model of trained and sedentary mice. A group of mice underwent endurance training while another set led a sedentary lifestyle and were freely mobile

Effects of different doses of nandrolone decanoate on estrous cycle and ovarian tissue of rats after treatment and recovery periods This study tested the hypothesis that different doses of nandrolone decanoate (ND) will cause changes in the estrous cycle and ovarian tissue of adult rats; and investigated the duration of the recovery period that is sufficient to restore the damage in the animals

Effect of supraphysiological dose of Nandrolone Decanoate on the testis and testosterone concentration in mature and immature male rats: A time course study Most studies on anabolic-androgenic steroids abuse have been done in adult rats, but few data are available to immature. This study was conducted to assay the effect of Nandrolone Decanoate (ND) on the testis and testosterone concentration

Evaluation of safety and effectiveness of Nandrolone Decanoate in adults: a systematic review PROSPEROInternational prospective register of systematic reviews Print | PDFEvaluation of safety and effectiveness of Nandrolone Decanoate in adults: a systematic reviewIzabelle de Mello Gindri, Gustavo Ferrari, Isis Kelly Santos, Luiz Paulo de Souza Pinto, Carlos Rodrigo de Mello RoeslerTo enable here.CitationIzabelle de Mello Gindri, Gustavo Ferrari, Isis Kelly Santos, Luiz Paulo de Souza Pinto, Carlos Rodrigo de Mello Roesler. Evaluation of safety and effectiveness of Nandrolone Decanoate in adults: a systematic review. PROSPERO 2023 CRD42023396431 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023396431Review questionIs Nandrolone Decanoate safe and effective for treatment

Pharmacokinetic-Pharmacodynamic Study of Subcutaneous Injection of Depot Nandrolone Decanoate Using Dried Blood Spots Sampling Coupled With Ultrapressure Liquid Chromatography, Tandem Mass Spectrometry (LC-MS) Assays. Testosterone (T) and nandrolone (N) esters require deep im injections by medical personnel but these often deposit injectate into sc fat so that more convenient sc self

Impact of nandrolone decanoate on physical function, body composition, and bone mineral density: a systematic review and meta-analysis PROSPEROInternational prospective register of systematic reviews Print | PDFImpact of nandrolone decanoate on physical function, body composition, and bone mineral density: a systematic review and meta-analysisKonstantinos Prokopidis, Theocharis Ispoglou Giannos, Joseph McLean, Luca Paoletti, Brigid Unim, Pinar Soysal, Trevor Thompson, Antonio Cherubini, Olivier Bruyère, Nicola Veronese. Impact of nandrolone decanoate on physical function, body composition, and bone mineral density: a systematic review and meta-analysis. PROSPERO 2022 CRD42022367273 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022367273Review question

(testosterone and dihydrotestosterone and the less potent an-drostenedione) increasing protein synthesis. In patients withadvanced cancer, decreased free testosterone levels are frequentlyobserved [70]. Typical representatives of androgens investigatedin cancer patients include nandrolone decanoate (for i. m. use200 mg per week) and oral oxandrolone orfluoxymesterone(20 mg per day).In a randomized trial of 37 patients with non small cell lungcarcinoma undergoing chemotherapy, nandrolone decanoate(200 mg per week) was compared to no additional therapy; thenandrolone-treated group showed a trend toward a smaller loss ofbody weight [71]. An RCT that included 475 cachectic cancer pa-tients compared a steroid, a progestin, andfluoxymesterone.Fluoxymesterone (20 mg/day) resulted in less appetite

. The experimental group received weekly intramuscular injections of nandrolone decanoate for 9 weeks. Following euthanasia and dissection of the VFs, histomorphometric analysis of the TA muscle, immunohistochemical evaluation of ARs, and measurement of HA concentration using the ELISA-like fluorimetric method were performed. The experimental group exhibited a significantly larger mean fiber cross-sectional area

and preliminary effect of a 12-week intervention consisting of anabolic steroid in addition to physiotherapy and nutritional supplement on knee-extension strength and function after hip fracture surgery. Patients were randomized (1:1) during acute care to: 1. Anabolic steroid (Nandrolone Decanoate) or 2. Placebo (Saline). Both groups received identical physiotherapy (with strength training) and a nutritional

pharmacokinetic study of three single doses (12.5, 25, 50 mg) of testosterone cream administered in random sequence on different days with at least 2 days between doses to healthy eugonadal volunteers with endogenous testosterone suppressed by administration of nandrolone decanoate. Serum testosterone, DHT and estradiol concentrations were measured by liquid chromatograpy, mass spectrometry in extracts of serum

intramuscular injection of nandrolone decanoate as the PON1 inhibitor. Triglyceride, cholesterol, HDL, and low-density lipoprotein (LDL) were determined and both cholesterol accumulation in aorta and fatty streak formation were evaluated. The comparison of the results in three groups reveals that cholesterol level in the group received cholesterol-enriched diet plus once daily injection of PON1 inhibitor