Poliosis and Neurofibromatosis Type 1: Two Familiar Cases and Review of the Literature Two brothers were referred to our clinic for reevaluation of neurofibromatosis type 1 (NF1). Both brothers presented a peculiarity that is not so common in NF1: poliosis overlying plexiform neurofibromas on the scalp. Poliosis overlying plexiform neurofibromas is rarely reported in the literature . The peculiarity of our cases is the familiarity and the presence of poliosis in the same location.
Poliosis circumscripta unmasking a scalp melanoma. A 28-year-old man presented with a 1-year history of a localized patch of grey hair and an underlying darkly pigmented lesion on his right occipital area. Clinical appearance revealed poliosis overlying an asymmetrical plaque with variable degrees of brown pigmentation and white discolouration. Owing to the suspicious nature of the lesion , excision with a 2 mm margin was performed. Histology revealed an invasive melanoma with extensive regression and prominent involvement of multiple hair follicles. Scalp melanoma with associated poliosis is extremely rare, and has only been reported once in the literature to date. There have been two reports in the opthalmology literature regarding eyelash poliosis associated with orbital melanoma
Poliosis circumscripta: Overview and underlying causes. Although traditionally known as "white forelock," poliosis circumscripta, defined as a localized patch of white hair in a group of hair follicles, can involve any hairy area on the body including the scalp, eyebrows, and eyelashes. Microscopically, poliosis demonstrates either decreased or absent melanin and/or melanocytes in the hair bulbs of the affected hair follicles. Classically, poliosis is known to occur in the setting of several genetic syndromes including piebaldism, Waardenburg, and tuberous sclerosis. In addition, poliosis has been described in association with various acquired conditions. These include inflammatory conditions, benign and malignant neoplastic entities that are mainly melanocytic, medications, and others. In this review
Repigmentation of Poliosis After Epithelial Grafting for Vitiligo. Vitiligo is a disease of color loss from skin and possibly also from hair. The presence of white hair follicles is known to be a bad prognostic sign. To evaluate the possibility of repigmentation of white hair follicles after epithelial grafting. Patients with recalcitrant vitiligo with loss of hair pigment were treated using Chinese cupping blisters or ultrathin Thiersch grafting after de-epithelialization of vitiliginous patches by dermabrasion. Phototherapy was used afterward to enhance success. Repigmentation of the skin surface was obtained with as little as 1 to 2 months of phototherapy, as expected, and further follow-up of cases revealed the re-coloring of hair follicles after 4 to 11 months. Re-coloring of poliosis
(trichiasis), or depigmentation (poliosis). * Eyelid thickening, ulceration, or scarring, which can cause the eyelid to turn inwards against the eyeball (entropion) or outwards (ectropion). * Complications involving the eyes include: * Contact lens intolerance. * Dry eye disease (keratoconjunctivitis sicca). For more information, see the CKS topic on Dry eye disease. * Chronic conjunctivitis. For more
the two groups. Morphological evaluation included number of upper (UL) and lower lid (LL) eyelash rows, poliosis, individual elongated eyelash and eyelash curvature. Masked evaluation of all the patients was performed. We found 11 patients, of which 6 treated with PGs for glaucoma and 5 treated with TKIs for non-ocular cancer suspected of dissemination. TKIs-induced MT was characterized by more individual elongated eyelashes (p = .047), UL eyelash rows (p = .03) and eyelash curvature (p = .076); poliosis characterized PGs-induced MT (p = .076). MT-associated complaints were more frequent in TKIs-induced MT (p = .06). time from drug administration to MT onset was shorter with TKI compared to PGs (median 176 Vs. 440 days, p = .257). The study suggests that TKI-induced MT presents faster than PGs
Effect of prednisone plus either adalimumab or cyclosporine on dermatological symptoms in Vogt-Koyanagi-Harada disease: systemic outcomes from a randomized trial. Vogt-Koyanagi-Harada (VKH) disease causes vitiligo, poliosis, and alopecia. To investigate the effect of prednisone plus either adalimumab or cyclosporine-based immunosuppression on VKH dermatological disorders using ancillary data from a VKH eye disease trial. Patients with VKH disease treated with individualized prednisone tapering (maximum daily dose, 40 mg; maximum duration, 6 months) were randomized to adjunctive adalimumab (N=54) or cyclosporine (N=56). Outcomes included changes in vitiligo, poliosis, and alopecia at month 6. Overall, there was a decrease in the percentage of alopecia but no change in the presence
of the iris, lens and choroid, strabismus, poliosis of eyelashes, papilloedema, and sector iris depigmentation.78Eye – recommendations and results of consensusDelphi consensusThere was consensus to perform a baseline ophthalmologic evaluation, including fundoscopic evaluation for all individuals diagnosed with TSC to evaluate for hamartomas and hypo-pigmented lesions of the retina.There was no agreement
for crusting (collarettes) or hard scales (staphylococcal disease) and for greasiness (seborrhoeic disease). Trichiasis (in-turning of lashes) and poliosis (whitening of lashes) may occur in long-standing disease.Lid margin - look for inflammation around the meibomian gland orifices or the capping of the meibomian gland orifices (looks like a row of yellow droplets along the lid margin) of meibomian infection of the follicle of an eyelash.Trichiasis (inward-turning of eyelashes).Madarosis (loss of eyelashes).Poliosis (loss of pigment from eyelashes).Lid scarring and ulceration. This can in turn cause ectropion or entropion.Complications involving the rest of the eyeContact lens intolerance is common.Dry eye syndrome is also common - particularly in posterior blepharitis.Conjunctivitis - results from
there is decreased or absent melanin in the affected hair follicles. Classically, poliosis is associated with several genetic syndromes, including piebaldism, Waardenburg's syndrome and tuberous sclerosis. It may be associated with inflammation: ocular causes include chronic anterior blepharitis and sympathetic ophthalmitis. In rare cases, it has been seen as an early manifestation of conjunctival READING AND REFERENCESFerreira IS, Bernardes TF, Bonfioli AA; Trichiasis. Semin Ophthalmol. 2010 May25(3):66-71.Sleiman R, Kurban M, Succaria F, et al; Poliosis circumscripta: overview and underlying causes. J Am Acad Dermatol. 2013 Oct69(4):625-33. doi: 10.1016/j.jaad.2013.05.022. Epub 2013 Jul 12.Kumar A, Karthikeyan K; Madarosis: a marker of many maladies. Int J Trichology. 2012 Jan4(1):3-18. doi
peripheral inflammatory border as well as a poliosis. The patient also had pearly white atrophic papular plaques at the level of the interscapular and abdominal regions as well as of the anterior face of the knees. Two biopsies were performed. Histological examination of an achromic macula showed vitiligo with inflammatory reaction while histological examination of an infiltrated lesion allowed
sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes and scalp and body hair. Compared with baseline high-resolution three-dimensional total-body photography, we observed fading or disappearance of solar lentigines, seborrhoeic keratoses and melanocytic
as in pigmented subjects. Ocular involvement is often associated with neurological (meningeal stiffness, headache, sometimes associated with focal deficit and erebrospinal fluid (CSF) pleocytosis), auditory ( perceptive deafness) and cutaneous (vitiligo, poliosis, alopecia and canities) manifestations. It usually evolves in three phases: a prodromal phase mainly characterized by neurological signs, an acute
macules and poliosis (A) with no contrast enhancement under Wood lamp and several coffee-with-milk colored spots on the trunk and thighs(B). The diagnosis of piebaldism was made. Piebaldism is a rare genodermatosis. Its incidence is estimated at less than 1/20000 newborns. It is characterized by the congenital absence of melanocytes in the areas affected by mutation of the c-kit gene and by symmetrical
(r = -0.114, P < 0.001), whereas it was positively correlated with treatment frequency (r = 0.270, P < 0.001). Lesions with concurrent poliosis were more likely resistant to treatments. 308-nm excimer laser appears to be an effective and safe treatment in Chinese vitiligo patients. The clinical response and treatment efficacy was affected by many factors such as age, affected anatomical area, shape
identified from our clinics. Methods include the review of the history and clinicopathologic features. Three patients (75%) had AA and one had universalis. Two patients had a resolution after topical, oral or intralesional therapies and one had a resolution after immunotherapy was discontinued; all regrown hair exhibited poliosis. One of the four patients had coincident onychodystrophy. This report