A rare case of infantile acute polymicrobial dacryocystitis due to Serratia marcescens, Haemophilus aphrophilus, and Prevotellaintermedia. Infantile acute dacryocystitis is an acute inflammation of the lacrimal sac in infants. The most common pathogens are Gram-positive cocci and Gram-negative rods. We report a case of infantile polymicrobial acute dacryocystitis. A 6-week-old girl presented emergently with eye edema, discharge, and fever. Symptoms resolved with nasolacrimal probing and systemic antibiotics. Intraoperative cultures were positive for Serratia marcescens, Haemophilus aphrophilus, and Prevotellaintermedia. This case highlights the importance of considering uncommon pathogens in the etiology of infantile dacryocystitis.
Prevotellaintermedia Aggravates Subclinical Hypothyroidism. Subclinical hypothyroidism (SCH) has been shown to be associated with microbiota. However, the association between SCH and oral microbiota has not yet been elucidated. The results of our previous clinical studies showed that was abundant in the oral microbiota of SCH patients. This study aimed to investigate the relationship between
Case report: isolated prevotellaintermedia causing intracranial infection detected using metagenomic next generation sequencing. Isolated Prevotellaintermedia, a rare gram-negative, rod-shaped, anaerobic bacterium, is rarely detected in clinical practice. It has been associated with infections of the oral cavity and female genital tract, but has never been detected in cerebrospinal fluid (CSF ) of patients in China. Accurate detection of causative pathogens is still an arduous task owing to the difficult conditions of anaerobic bacterial culture. Isolated Prevotellaintermedia can be detected by metagenomic next generation sequencing (mNGS) of the CSF. Correct diagnosis and antibiotic treatment can help patients avoid life-threatening events. Herein, we describe the case of a 64-year-old Chinese
Enrichment of Prevotellaintermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas. Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum and Bacteroides fragilis have been reported to be enriched in colorectal cancer (CRC) in multiple studies. Thus with clinicopathological features and genomic and genetic alterations were evaluated through odds ratio tests. Additionally, the effects of candidate bacteria on CRC cell proliferation, migration, and invasion were evaluated through the co-culture of CRC cells with bacterial cells or with conditioned media from bacteria. Prevotellaintermedia was overrepresented in adenocarcinomas compared with paired adenomatous polyps
The antibacterial effect of aquatic and methanolic extract of Myrtus communis on Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis and Prevotellaintermedia Anaerobic Gram negative bacteria are the main cause of periodontal destruction. It has been shown that have anti-bacterial activity on Gram positive and Gram negative bacteria. The aim of this study was to determine
Draft Whole-Genome Sequences of Periodontal Pathobionts Porphyromonas gingivalis, Prevotellaintermedia, and Tannerella forsythia Contain Phase-Variable Restriction-Modification Systems Periodontal disease comprises mild to severe inflammatory host responses to oral bacteria that can cause destruction of the tooth-supporting tissue. We report genome sequences for 18 clinical isolates
A chinese case of prevotellaintermedia and streptococcus constellatus intracranial mixed infection Streptococcal Species is increasingly recognized as a potentially preventable emerging infection in human's brain with high prevalence around the world. Streptococcus constellatus is one of the most common pathogens. Meanwhile, anaerobic bacteria are the rare causes for intracranial infection . To date, intracranial mixed infection caused by Prevotellaintermedia and Streptococcus constellatus has not been reported. We reported a Chinese case to raise the global awareness of severity of the intracranial mixed infection. Here, we illustrated the epidemiological risk factors, clinical manifestations and outcomes of the patient. For patients who suffer from exacerbated brain infection with fetid
Association of Distinct Fine Specificities of Anti−Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotellaintermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis In addition to the long-established link with smoking, periodontitis (PD) is a risk factor for rheumatoid arthritis (RA). This study was undertaken to elucidate the mechanism by which PD exhibited elevated antibody responses in RA patients (24%). Anti-cCK13-1 antibody levels correlated with anti-cTNC5 antibody levels, and absorption experiments confirmed this was not due to cross-reactivity. Only anti-cCK13-1 and anti-cTNC5 were associated with antibodies to the periodontal pathogen Prevotellaintermedia (P = 0.05 and P = 0.001, respectively), but not with antibodies to Porphyromonas
Population-Genomic Insights into Variation in Prevotellaintermedia and Prevotella nigrescens Isolates and Its Association with Periodontal Disease High-throughput sequencing has helped to reveal the close relationship between and periodontal disease, but the roles of subspecies diversity and genomic variation within this genus in periodontal diseases still need to be investigated. We performed
Prevotellaintermedia infection causing acute and complicated aortitis—A case report Aortitis is a general term that refers to all conditions involving an inflammation of the aortic wall. This case report describes the surgical approach of a patient with infectious and symptomatic aortitis caused by the rare vector Prevotellaintermedia. A 44-year old male patient was admitted with fever ). An urgent aortic reconstruction was performed according to Nevelsteen. The blood cultures turned out positive for Prevotellaintermedia. Postoperatively the patient received antibiotics for six weeks. The patient recovered uneventful from this infection and surgical procedure. A complicated and acute aortitis is a rare but potentially life-threatening disease. The aetiology can be ordered into two main
Genome sequence of Prevotellaintermedia SUNY aB G8-9K-3, a biofilm forming strain with drug-resistance Prevotellaintermedia has long been known to be as the principal etiologic agent of periodontal diseases and associated with various systemic diseases. Previous studies showed that the intra-species difference exists in capacity of biofilm formation, antibiotic resistance, and serological
A Preliminary Study of the Effects of pH upon Fluorescence in Suspensions of Prevotellaintermedia The quantification of fluorescence in dental plaque is currently being developed as a diagnostic tool to help inform and improve oral health. The oral anaerobe Prevotellaintermedia exhibits red fluorescence due to the accumulation of porphyrins. pH affects the fluorescence of abiotic preparations
Human dental stem cells suppress PMN activity after infection with the periodontopathogens Prevotellaintermedia and Tannerella forsythia Periodontitis is characterized by inflammation associated with the colonization of different oral pathogens. We here aimed to investigate how bacteria and host cells shape their environment in order to limit inflammation and tissue damage in the presence
Nucleases from Prevotellaintermedia can degrade neutrophil extracellular traps Periodontitis is an inflammatory disease caused by periodontal bacteria in subgingival plaque. These bacteria are able to colonize the periodontal region by evading the host immune response. Neutrophils, the host's first line of defense against infection, use various strategies to kill invading pathogens, including antimicrobial mechanism, leading to increased pathogenicity. Here, we compared the DNA degradation activity of major Gram-negative periodontopathogenic bacteria, Porphyromonas gingivalis, Prevotellaintermedia, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. We found that Pr. intermedia showed the highest DNA degradation activity. A genome search of Pr. intermedia revealed the presence
Expression Profiles of TGF-β and TLR Pathways in Porphyromonas gingivalis and Prevotellaintermedia Challenged Osteoblasts The presence of certain oral pathogens at implant sites can hinder the osseointegration process. However, it is unclear how and by what microorganisms it happens. This study investigated whether the presence of oral pathogens of Porphyromonas gingivalis and Prevotellaintermedia individually, play a role in the failure of bone formation by determining the expression profiles of Transforming Growth Factor Beta (TGF-β/Bone Morphogenic Protein (BMP) and Toll-Like Receptor (TLR) pathways in challenged osteoblasts. Cell viability of P. gingivalis and P. intermedia challenged osteoblasts were determined by WST assay. Changes in osteoblast morphology and inhibition
Determination of antibacterial activity of green coffee bean extract on periodontogenic bacteria like Porphyromonas gingivalis, Prevotellaintermedia, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans: An in vitro study The aim of this study was to evaluate the antibacterial activity of pure green coffee bean extract on periodonto pathogenic bacteria Porphyromonas gingivalis (Pg ), Prevotellaintermedia (Pi), Fusobacterium nucleatum (Fn) and Aggregatibacter actinomycetemcomitans (Aa). Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) were used to assess the antibacterial effect of pure green coffee bean extract against periodonto pathogenic bacteria by micro dilution method and culture method, respectively. MIC values of Pg, Pi and Aa were 0.2 μg
In vitro effects of polyphosphate against Prevotellaintermedia in planktonic phase and biofilm. Polyphosphate (polyP) has gained a wide interest in the food industry due to its potential as a decontaminating agent. In this study, we examined the effect of sodium tripolyphosphate (polyP3; Na5P3O10) against planktonic and biofilm cells of Prevotellaintermedia, a major oral pathogen. The MIC
Scaling and root planning, and locally delivered minocycline reduces the load of Prevotellaintermedia in an interdependent pattern, correlating with symptomatic improvements of chronic periodontitis: a short-term randomized clinical trial. To evaluate the respective or combinatory efficacy of locally delivered 2% minocycline (MO), and scaling and root planning (SRP) by assessing both clinical main periodontal pathogens (Aggregatibacter actinomycetemcomitans [Aa], Fusobacterium nucleatum [Fn], Porphyromonas gingivalis [Pg], and Prevotellaintermedia [Pi]). The bacterial prevalence per patient was: Aa, 31.25%; Fn, 100%; Pg, 95.31%; and Pi, 98.44%. Seven days after treatment, the three treatments significantly reduced both PD and SBI, but not detection frequencies of the four pathogens
The complete genome sequencing of Prevotellaintermedia strain OMA14 and a subsequent fine-scale, intra-species genomic comparison reveal an unusual amplification of conjugative and mobile transposons and identify a novel Prevotella-lineage-specific repea Prevotellaintermedia is a pathogenic bacterium involved in periodontal diseases. Here, we present the complete genome sequence of a clinical
Progression of periodontal inflammation in adolescents is associated with increased number of Porphyromonas gingivalis, Prevotellaintermedia, Tannerella forsythensis, and Fusobacterium nucleatum. The study aims to evaluate the change of related subgingival periodontopathogens among different stage of gingivitis in adolescent and assess the relationship between periodontopathogens and the progression of periodontal inflammation. A total of 77 subgingival plaque samples from 35 adolescent individuals were divided into three groups including gingivitis group (mild, 15 samples; moderate, 16 samples; severe, 15 samples), chronic periodontitis group (15 samples) and healthy group (15 samples). Real-time PCR was used to quantitate Porphyromonas gingivalis, Prevotellaintermedia, Tannerella