Coupling of RigorMortis and Intestinal Necrosis during C. elegans Organismal Death Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigormortis, a postmortem necrosis-related process in which Ca influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. VIDEO ABSTRACT.
should be clarified: use the concept of “irreversible death” rather than “impractical resuscitation” in the MED-LEG.2 protocol; replace the criterion of “unable to ventilate due to rigormortis” with “rigormortis, postmortem lividity or putrefaction” in the MED-LEG.2 protocol; define rigormortis, putrefaction and lividity in the MED-LEG.2 protocol (irreversible death); clarify the roles
greater stress, less firm fillet texture and greater weight loss due to cooking, as well as changes in creatine kinase (CK) and its CK-MB isoenzyme, demonstrating greater muscle damage. On the other hand, the density of 50 kg m-3 during pre-slaughter, combined with the method of stunning by thermonarcosis, provide a longer period of permanence in pre rigormortis, which will result in fillets
, gingival tissue has emerged as interesting for forensic analysis thanks to the protection offered by lips to this tissue, limiting the influence of environmental factors. It is also easily accessible, and its sampling is minimally invasive even in the presence of rigormortis. Moreover, the expression of HIF-1α, a master mediator of the hypoxic environment, has been described in gingival samples
).Evidence of prolonged circulatory arrest (e.g., rigormortis, dependent lividity, decomposition).Advance care planning documents that indicate Do Not Resuscitate (DNR)/ Do Not Attempt Resuscitation (DNAR)/Allow Natural Death medical orders.Conditions where resuscitation attempts are discontinued for TOHCA patients should recognize:Mechanism of injury should not be used as the sole determinant
measurements; however, on average 3D scans overestimated length and head circumference by 1.61 cm and 2.27 cm, respectively. Site staff preferred manual anthropometry to 3D imaging, as the imaging technology required adequate lighting and additional considerations when performing the measurements. Manual anthropometry was feasible and reliable postmortem in the presence of rigormortis. 3D imaging may
intracellular CoQ levels. Mitochondrial function was compromised, as indicated by the decrease in oxygen consumption, restored by CoQ supplementation. Transcriptomic analysis of GEMIN5 patients compared with controls showed general repression of genes involved in CoQ biosynthesis. In the rigormortis defective flies, CoQ levels were decreased, and CoQ supplementation led to an improvement in the adult
to TMS-5 and TMS-10 treated animals by T2h. Neither TMS-5, TMS-10, nor Bupi-1.5 ceased heart rate after the 1-h immersion. Experiment two-after the 5-h immersion, Bupi-1.5 and TMS-5 treated animals were comparable in heart rates. 43% of TMS-5 animals and 14% of the Bupi-1.5 animals had completely ceased heart rates at T5h. At 19 h all remaining animals exhibited rigormortis and had ceased heart rate
DNR orderNote: fixed & dilated pupils, areflexiaor stiffness that resembles rigormortis are not reliable indicators of death in hypothermia.Consider standard TOR (termination of resuscitation guidelines) Cardiac arrest from alternate cause prior to coolingMajor trauma, hypoxia or medical conditionWitnessed normothermicarrestConsider standard TORConsider tests to exclude need for ECMO/CPBCore
before a thermometer or thermo-couple is introduced. If, for some reason, it is not practical to measure the body temperature at the scene, it may be recorded as soon as practicable upon arrival of the body at the mortuary. The degree, location and fixation of rigormortis and hypostasis should be noted. 5.2.7 Other aspects of scene examination Detailed examination of the scene . If not already dealt with at the scene, rigormortis should be systematically tested for if potentially of relevance to the case. Signs of treatment should be recorded. Medical devices should not be removed from the body before the autopsy. 6.3.3 Examination of injuries All injuries must be described by shape, exact measurements, direction, edges and angles. The location relative
regression analysis was used to identify factors influencing when people considered it suitable to initiate cardiopulmonary resuscitation. The study involved 4289 participants from 31 provinces, autonomous regions and municipalities in mainland China, of whom 52.8% were male. The top three reasons for not attempting cardiopulmonary resuscitation were decomposition/hypostasis/rigormortis (6.39 ± 1.44
of consciousness occurs in 15 seconds * brief seizures may occur for a few seconds due to decreased cerebral flow (hypoxic etiology) * respiratory arrest often may progress to cardiac arrest1) List 4 contraindications to CPR 1. do not resuscitate (DNR) order 2. unwitnessed cardiopulmonary arrest in a patient who appears frozen/cold to touch or in rigormortis (and no shockable rhythm) 3. traumatic arrest 4
: only performed in low resource settingsDispositionED role: * resuscitation and stabilization and transfer to appropriate facility * avoid extensive imaging if your centre can’t deal with the results * low threshold for admission with serial examsCessation of care: * obvious if * livor mortis, rigormortis, massive injuries * attempts should be made if there are signs of life * parental presence
&link_type=MED&atom=%2Febnurs%2F18%2F2%2F34.atom) [Web of Science](http://ebn.bmj.com/lookup/external-ref?access_num=000234984900009&link_type=ISI) 3. Sandelowski M. Rigor or rigormortis: the problem of rigor in qualitative research revisited. Adv Nurs Sci 1993;16:1–8. [doi:10.1097/00012272-199312000-00002](http://dx.doi.org/10.1097/00012272-199312000-00002) [PubMed](http://ebn.bmj.com/lookup/external-ref
(patients on ventilators, for example).Guidance on the diagnosis and confirmation of death from the Academy of Medical Royal CollegesProceed without unnecessary and distressing delay. Death may be obvious with clear signs pathognomonic of death (hypostasis, rigormortis). If not, obvious death should be identified by "the simultaneous and irreversible onset of apnoea and unconsciousness in the absence one minute).There are no heart sounds or palpable pulses (examine for at least one minute).There is an absence of reflexes - eg, corneal.The pupils are fixed and dilated.Remote verification of expected deathThe BMA and the RCGP have drawn up a protocol to be used when a doctor is guiding a non-medical person to verify an expected death via a mobile phone and camera, viz[4]:If rigormortis
coincided with his cleavage lines.The Langer diagrams were developed from cadavers in a uniform position, with their extremities in extension as they were in rigormortis. Langer discovered that his lines changed depending on the position of the cadaver. For instance, the longitudinal orientation of a wound in the antecubital fossa changes to transverse when the elbow is relaxed versus when
, it is not practical to measure the body temperature at the scene, it may be recorded as soon as practicable upon arrival of the body at the mortuary. The degree, location and fixation of rigormortis and hypostasis should be noted. Police officers should not allow police surgeons or forensic medical examiners to make such measurements without prior discussion with the pathologist