"Single transverse palmar crease" from_date:2012

. Definition (NCI) A syndrome characterized by the presence of three complete copies of genetic material for chromosome 21, instead of the normal two. It leads to a variety of abnormalities that include mental retardation, macroglossia, microgenia, epicanthic eyelids, and a single transverse palmar crease

with Down syndrome may include the following: * * Shortened extremities * * Short, broad hands, with short fifth finger with hypoplasia of the middle phalanx and clinodactyly, along with single transverse palmar creases (~60% of patients) * * Joint hyperextensibility or hyperflexibility * * Neuromuscular hypotonia * * Diastasis recti * * Dry skin

with Down syndrome may include the following: * * Shortened extremities * * Short, broad hands, with short fifth finger with hypoplasia of the middle phalanx and clinodactyly, along with single transverse palmar creases (~60% of patients) * * Joint hyperextensibility or hyperflexibility * * Neuromuscular hypotonia * * Diastasis recti * * Dry skin

. Definition (NCI) A syndrome characterized by the presence of three complete copies of genetic material for chromosome 21, instead of the normal two. It leads to a variety of abnormalities that include mental retardation, macroglossia, microgenia, epicanthic eyelids, and a single transverse palmar crease

very subtle but may include epicanthal folds (skin folds at the inner corners of one or both eyes), downward slanting palpebral fissures, broad forehead, a flattened nasal bridge, button nose, and a high arched palate (roof of the mouth). Some individuals show other signs that can often be associated with chromosomal conditions, such as pectus excavatum, or a unilateral or bilateral single transverse palmar crease. Many individuals with idic(15) display features of autism, such as problems with communication and social interactions, obsessional interests (often with interactive mechanisms like wheels, doors or switches), unpredictable sleep cycles (and a reduced need for sleep), and repetitive and stereotyped behaviors (e.g., lining up toys, playing with a toy in the same manner over and over again

] Narrow roof of mouth 76%[26] Bent fifth finger tip 57%[12] Flat head 75%[12] Brushfield spots in the iris 56%[12] Flexible ligaments 75%[12] Single transverse palmar crease 53%[12] Proportionally large tongue[30] 75%[29] Protruding tongue 47%[26] Abnormal