"Substituted amphetamine" from_date:2012

Severe poisoning after self-reported use of 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine, a novel substituted amphetamine: a case series. Significant toxicity from amphetamine and cathinone derivatives is being increasingly reported. We describe a series of self-reported exposures to 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25-I-NBOME or 25-I

chemical known as a party drug, used in raves and nightclubs.1,2 MDMA acts as both a stimulant and hallucinogen, and belongs to a class of drugs known as substituted amphetamines.* MDMA was studied as a possible supplement to psychotherapy in the 1970s and ’80s.3 More recently, there is growing research exploring MDMA-assisted psychotherapy for treating post-traumatic stress disorder (PTSD), eating disorders, anxieties related to life-threatening illnesses and neurodevelopmental disorders.4–10 O ngoing research studies use medical-grade MDMA† in clinically supervised settings. However, Canada does not have any MDMA products approved for therapeutic use.11 Further study is needed to examine any adverse cognitive effects of clinically relevant doses of MDMA.10 * Substituted amphetamines are a class

disorder. Psychedelics also have properties that could help provide therapeutic benefits for patients with dementing disorders, as well as promoting personal growth among healthy older adults. This article focuses on psilocybin, a classic psychedelic, and MDMA, a substituted amphetamine with properties similar to classic psychedelics. Both act on the 5HT receptor. Psychedelics can be safely administered

effects on the conduction system and through several direct and indirect pathways, utilizing multiple second messenger systems, change the structural and electrical substrate of the heart, thereby promoting cardiac dysrhythmias. Substituted amphetamines and cocaine affect the expression and activation kinetics of multiple ion channels and calcium signaling proteins resulting in EKG changes, and atrial

consequences of substituted amphetamines are associated with different effects on inhibitory control over behavior. Thus, the course of addiction and maladaptive behavior resulting from exposure to these substances is likely to differ.

Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine The substituted amphetamine, 2,5-dimethoxy-4-iodoamphetamine (DOI), is a hallucinogen that has been used to model a variety of psychiatric conditions. Here, we studied the effect of DOI on neural activity recorded simultaneously in the primary motor

regulatory control, leading to the manufacture of many new potentially dangerous drugs. Bromoamphetamine analogs (bromoamphetamine [Br-AP] and bromomethamphetamine (Br-MA]) are ring-substituted amphetamines that can behave as stimulants, as well as exhibiting inhibitory activity towards monoamine oxidases in the same way as amphetamines. Gas chromatography-tandem mass spectrometry (GC-MS-MS) was used

. Furthermore, results from Risk of Bias assessment will be presented in the discussion.Analysis of subgroups or subsetsRegarding efficacy analyses, we will perform subgroup analyses, considering different psychedelic classes (Tryptamines, Phenethylamines, Lysergamides, cathinones, Ibogoids, Substituted amphetamines, harmalines, salvinorin), considering different comparators (single molecules), when

(NCI) A ring-substituted amphetamine derivative, structurally related to the hallucinogen mescaline, with entactogenic, neurotoxic, and motor-stimulatory activities. 3,4-methylenedioxymethamphetamine (MDMA) produces an acute, rapid enhancement in both the release of serotonin from and the inhibition of serotonin reuptake by serotonergic nerve endings in the brain. Once within the cell, MDMA . Definition (MSH) An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy

Serotonin Reuptake Transporter Deficiency Modulates the Acute Thermoregulatory and Locomotor Activity Response to 3,4-(±)-Methylenedioxymethamphetamine, and Attenuates Depletions in Serotonin Levels in SERT-KO Rats 3,4-(±)-Methylenedioxymethamphetamine (MDMA) is a ring-substituted amphetamine derivative with potent psychostimulant properties. The neuropharmacological effects of MDMA are biphasic

and changing group of drugs among the hallucinogens. While this is an ever-changing, some of the common substances include the MDMA congeners (eg, MDA, MDEA, MDPV), the 2C family of drugs (eg, NBOMe, 2CB, 2CI, and Bromodragonfly), and the D series of ring-substituted amphetamines (eg, DOB, DOI, DOM).This category is likely the most dangerous group of drugs, for many reasons. These drugs are typically made

and changing group of drugs among the hallucinogens. While this is an ever-changing, some of the common substances include the MDMA congeners (eg, MDA, MDEA, MDPV), the 2C family of drugs (eg, NBOMe, 2CB, 2CI, and Bromodragonfly), and the D series of ring-substituted amphetamines (eg, DOB, DOI, DOM).This category is likely the most dangerous group of drugs, for many reasons. These drugs are typically made

(NCI) A ring-substituted amphetamine derivative, structurally related to the hallucinogen mescaline, with entactogenic, neurotoxic, and motor-stimulatory activities. 3,4-methylenedioxymethamphetamine (MDMA) produces an acute, rapid enhancement in both the release of serotonin from and the inhibition of serotonin reuptake by serotonergic nerve endings in the brain. Once within the cell, MDMA . Definition (MSH) An N-substituted amphetamine analog. It is a widely abused drug classified as a hallucinogen and causes marked, long-lasting changes in brain serotonergic systems. It is commonly referred to as MDMA or ecstasy

by the substituted amphetamines methamphetamine and mephedrone (4-methylmethcathinone) but was much less effective against nicotine. When tested in the presence of the glutamate transporter inhibitor dihydrokainate (DHK) (0.1, 1 μM), harmine (0.1 μM) efficacy against cocaine-induced C-shapes was significantly reduced. Harmine also attenuated C-shapes elicited by N-methyl-d-aspartate (NMDA) and by glutamate itself

heart defects.[16]Bupropion acts as a norepinephrine–dopamine reuptake inhibitor and a nicotinic receptor antagonist.[5] Chemically, it is an aminoketone that belongs to the class of substituted cathinones and more generally that of substituted amphetamines and substituted phenethylamines.[1][17]Bupropion was invented by Nariman Mehta, who worked at Burroughs Wellcome, in 1969.[18] It was first

* History and culture of substituted amphetamines * Methamphetamine * Methylphenidate * Recreational drug use * Serotonin * Substituted amphetamine

risk of serious side effects.[sources 3]Amphetamine belongs to the phenethylamine class. It is also the parent compound of its own structural class, the substituted amphetamines,[note 5] which includes prominent substances such as bupropion, cathinone, MDMA, and methamphetamine. As a member of the phenethylamine class, amphetamine is also chemically related to the naturally occurring trace amine to alcohol, cannabinoids, cocaine, methylphenidate, nicotine, opioids, phencyclidine, propofol, and substituted amphetamines, among others.[sources 10]ΔJunD, a transcription factor, and G9a, a histone methyltransferase enzyme, both oppose the function of ΔFosB and inhibit increases in its expression.[95][107][117] Sufficiently overexpressing ΔJunD in the nucleus accumbens with viral vectors can completely

if they are present during sleep, may be signs of hyperthyroidism or anemia (see below).[5] * Central nervous system stimulants such as substituted amphetamines increase heart rate. * Central nervous system depressants or sedatives decrease the heart rate (apart from some particularly strange ones with equally strange effects, such as ketamine which can cause – amongst many other things – stimulant-like effects