Guidelines for the management of Toxoplasmagondii infection and disease in patients with haematological malignancies and after haematopoietic stem-cell transplantation www.thelancet.com Verify you are human by completing the action below. www.thelancet.com needs to review the security of your connection before proceeding.Ray ID: 90515bd69ce2ed12Performance & security by Cloudflare
T-cell activation of Toxoplasmagondii positive donors by maltodextrin nanoparticles formulated with killed Toxoplasmagondii. Nasal vaccination with killed tachyzoites from Toxoplasmagondii loaded in lipidated maltodextrin nanoparticles (NPL/T.gondii) has been shown to induce protection against lethal T.gondii infection in mice, sheep and squirrel monkeys. This protection was related
Coixol mitigates Toxoplasmagondii infection-induced liver injury by inhibiting the Toxoplasmagondii HSP70/TLR4/NF-κB signaling pathway in hepatic macrophages. Coix seed, the dry mature seed kernel of the gramineous plant coix (Coix lacryma-jobi L. var. ma-yuen Stapf), is widely consumed as a traditional Chinese medicine and functional food in China and South Korea. We have previously demonstrated the protective effect of coixol, a polyphenolic compound extracted from coix, against Toxoplasmagondii (T. gondii) infection-induced lung injury. However, the protective effect of coixol on hepatic injury induced by T. gondii infection have not yet been elucidated. This study explores the impact of coixol on T. gondii infection-induced liver injury and elucidates the underlying molecular
mGBP2 engages Galectin-9 for immunity against Toxoplasmagondii. Guanylate binding proteins (GBPs) are large interferon-inducible GTPases, executing essential host defense activities against Toxoplasmagondii, an invasive intracellular apicomplexan protozoan parasite of global importance. T. gondii establishes a parasitophorous vacuole (PV) which shields the parasite from the host's intracellular
Associations between Toxoplasmagondii seropositivity and psychopathological manifestations in schizophrenic patients: A single-center study from Ecuador. Schizophrenia, a complex neuropsychiatric disorder, is believed to be influenced by various factors including environmental exposures. A potential environmental factor is the infection by the obligate intracellular parasitic protozoan , Toxoplasmagondii which affects neurotransmitter levels, which could potentially exacerbate, trigger symptoms of schizophrenia or make them worst. To investigate the association between Toxoplasmagondii seropositivity and psychopathological presentation in persons with schizophrenia in Ecuador. This study was conducted at the Neuroscience Institute of Guayaquil, Ecuador. Among 368 inpatients, 104 were
Seroepidemological investigation of Toxoplasmagondii and Trichinella spp. in pigs reared by tribal communities and small-holder livestock farmers in Northeastern India. Toxoplasmagondii and Trichinella spp. are critical tissue-dwelling foodborne zoonotic parasites associated with pork consumption and pig rearing. Despite being a major pig-rearing region in the country, Northeastern India has
Toxoplasmagondii infection and high levels of IgE are associated to erythema nodosum leprosy (ENL). Leprosy is a chronic infectious disease caused by the bacillus Mycobacterium leprae. The disease may evolve for inflammatory reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL), the major cause of irreversible neuropathy in leprosy, which occur in 1 in 3 people with leprosy, even with effective treatment of M. leprae. Leprosy remains persistently endemic in our region where it predominantly affects lowest socioeconomic conditions people, as Toxoplasmagondii infection in the municipality studied. Previously, we have shown T. gondii coinfection as a risk marker for leprosy, mainly in its severe form. This present study assessed whether T. gondii infection is also a risk factor
Molecular prevalence, phylogeny and hematological impact of Toxoplasmagondii and Plasmodium spp. in common quails from Punjab, Pakistan. This study investigates the molecular prevalence and phylogenetic characteristics of two prominent blood-borne pathogens, Toxoplasmagondii (T. gondii) and Plasmodium spp., in common quails (Coturnix coturnix) sampled from both wild (N = 236) and farmed (N
Heligmosomoides bakeri and Toxoplasmagondii co-infection leads to increased mortality associated with changes in immune resistance in the lymphoid compartment and disease pathology. Co-infections are a common reality but understanding how the immune system responds in this context is complex and can be unpredictable. Heligmosomoides bakeri (parasitic roundworm, previously Heligmosomoides polygyrus) and Toxoplasmagondii (protozoan parasite) are well studied organisms that stimulate a characteristic Th2 and Th1 response, respectively. Several studies have demonstrated reduced inflammatory cytokine responses in animals co-infected with such organisms. However, while general cytokine signatures have been examined, the impact of the different cytokine producing lymphocytes on parasite control
Toxoplasmagondii in urban and rural bats from São Paulo state, Brazil. The aim of this study was to detect Toxoplasmagondii in organs of urban and rural bats from 17 cities in São Paulo, Brazil. A total of 203 bats, including insectivorous, frugivorous and hematophagous species, were collected from urban and rural areas between 2020 and 2022. DNA was extracted from heart and kidney samples
Immunization with Plant-based Vaccine Expressing Toxoplasmagondii SAG1 Fused to Plant HSP90 Elicits Protective Immune Response in Lambs. Toxoplasmagondii is a protozoan parasite causing toxoplasmosis, a principal concern for public health and livestock industries. Effective vaccination strategies are crucial for controlling toxoplasmosis, particularly in the lamb, which are significant
Latent Toxoplasmagondii infection and associated risk factors among patients with chronic kidney disease: a registry-based study. Patients with chronic kidney disease (CKD) are susceptible to acquiring opportunistic parasites due to acquired immunodeficiency caused by uremia. Therefore, the present case-control study attempted to determine the prevalence of T. gondii infection and also
Seroprevalence of Toxoplasmagondii infection among patients of a tertiary hospital in Guangzhou, Guangdong province, PR China. This study aimed to explore the prevalence of Toxoplasmagondii (T. gondii) among patients in Guangzhou city, South China, and to identify susceptible patient populations and analyze the causes of infection differences. From May 2020 to May 2022, a total of 637 sera
Prevalence of Toxoplasmagondii in Galapagos birds: Inference of risk factors associated with diet. Toxoplasmagondii is a zoonotic intracellular parasite of particular concern in the conservation of wildlife due to its ability to infect all homeotherms and potentially cause acute fatal disease in naive species. In the Galapagos (Ecuador), an archipelago composed of more than a hundred islets
Seroprevalence and associated risk factors of Toxoplasmagondii infection among slaughterhouse workers in Yangon Region, Myanmar: A cross-sectional study. Toxoplasmosis, having the significant consequences affecting mortality and quality of life, is still prevalent in various places throughout the world. The major gap in surveillance for Toxoplasmagondii infection among high-risk population
Survey on the association between Toxoplasmagondii infection and violent behavior in inmates. We evaluated the association between T. gondii seropositivity and violent behavior in a sample of inmates in Durango, Mexico. Through a cross-sectional study design, we studied 128 inmates (mean age: 35.89 ± 10.51; range: 19-65 years). Sera of participants were analyzed for anti-T. gondii IgG antibodies
More people, more cats, more parasites: Human population density and temperature variation predict prevalence of Toxoplasmagondii oocyst shedding in free-ranging domestic and wild felids. Toxoplasmagondii is a ubiquitous zoonotic parasite that can infect warm-blooded vertebrates, including humans. Felids, the definitive hosts, drive T. gondii infections by shedding the environmentally resistant
Differences in Toxoplasmagondii distribution in different muscle and viscera of naturally infected sheep. Toxoplasmagondii (T. gondii) is a zoonotic parasite that can cause serious pathology in intermediate hosts such as humans and animals. Eating undercooked or raw meat is the most important route of infection by T. gondii. Sheep are an important source of meat worldwide, and they are also
Prevalence and risk factors of Toxoplasmagondii infection among women with miscarriage and their aborted fetuses in the northwest of Iran. Toxoplasmosis is a worldwide disease of various animals and human and results from infection with the Toxoplasmagondii parasite. Abortion and congenital defects are important consequences of the T. gondii infection. The aim of this study was to determine
Defects in immune response to Toxoplasmagondii are associated with enhanced HIV-1-related neurocognitive impairment in co-infected patients. Human immunodeficiency virus-1 (HIV-1) and Toxoplasmagondii can invade the central nervous system and affect its functionality. Advanced HIV-1 infection has been associated with defects in immune response to T. gondii, leading to reactivation of latent