Photolysis of TrenboloneAcetate Metabolites in the Presence of Nucleophiles: Evidence for Metastable Photoaddition Products and Reversible Associations with Dissolved Organic Matter. Photolysis of trenboloneacetate (TBA) metabolites in the presence of various nitrogen-, sulfur-, or oxygen-containing nucleophiles (, azide, ammonia, or thiosulfate, respectively) results in rapid (half-lives ∼20
Evaluation of coated steroidal implants containing trenboloneacetate and estradiol-17β on live performance, carcass traits, and sera metabolites in finishing steers Crossbred beef steers (n = 240; 12 pens/treatment; initial BW = 305 ± 17.7 kg) were used in a randomized block design feedlot study to evaluate the influence of coated trenboloneacetate (TBA) and estradiol-17β (E2) implants (Merck
Reversible Photohydration of TrenboloneAcetate Metabolites: Mechanistic Understanding of Product-to-Parent Reversion through Complementary Experimental and Theoretical Approaches. Photolysis experiments (in H2O and D2O) and quantum chemical calculations were performed to explore the pH-dependent, reversible photohydration of trenboloneacetate (TBA) metabolites. Photohydration of 17α-trenbolone
Trenboloneacetate metabolite transport in rangelands and irrigated pasture: observations and conceptual approaches for agro-ecosystems. To assess the relative ecological risks of trenboloneacetate (TBA) use in agro-ecosystems, we evaluated the spatiotemporal dynamics of TBA metabolite transport during irrigation and rainfall events. Within a pasture, TBA-implanted heifers (40 mg TBA, 8 mg
Mass balance approaches to characterizing the leaching potential of trenboloneacetate metabolites in agro-ecosystems. Several studies have documented the occurrence and fate of trenboloneacetate (TBA) metabolites in soil and water. However, considerable uncertainty still exists with respect to TBA risk in agro-ecosystems because limited data are available to quantify excretion, transformation
Effects of estradiol benzoate and trenboloneacetate, alone or in combination at dose levels present in Synovex Choice, on performance by feedlot heifers. Trials were conducted with beef heifers at 4 sites to evaluate feedlot performance and carcass characteristics in response to implants containing 14 mg estradiol benzoate and 100 mg trenboloneacetate (EB/TBA; Synovex Choice, Zoetis LLC, New York, NY), 14 mg estradiol benzoate (EB), 100 mg trenboloneacetate (TBA), or a sham-implanted control (SC). The study design at each site was a randomized complete block with 12 blocks and 4 treatments. Blocks of cattle at each site were harvested in commercial abattoirs when masked personnel estimated at least 60% of animals would yield carcasses with USDA quality grades of Choice or Prime. Data
Fatty acids in carcass fat of steers treated with a β-adrenergic agonist individually or in combination with trenboloneacetate + oestradiol-17β. Forty steers of medium maturity were allocated randomly to four treatment groups of 10 steers each (C = Control, βA = β-Agonist, TO = Trenboloneacetate + oestradiol-17β and βTO = β-Agonist in combination with trenboloneacetate + oestradiol-17β
Identification and environmental implications of photo-transformation products of trenboloneacetate metabolites. Despite the widespread use of the anabolic androgen trenboloneacetate (TBA) in animal agriculture, evidence demonstrating the occurrence of TBA metabolites such as 17β-trenbolone (17β-TBOH), 17α-trenbolone (17α-TBOH), and trendione (TBO) is relatively scarce, potentially due to rapid
Administration of estradiol, trenboloneacetate, and trenboloneacetate/estradiol implants alters adipogenic and myogenic gene expression in bovine skeletal muscle. Twenty crossbred yearling steers (421 kg) were used to evaluate the effects of implanting with trenboloneacetate (TBA; 120 mg), estradiol-17β (E(2); 25.7 mg), and a combination (120 mg of TBA and 24 mg of E(2)) on adipogenic
The effect of combination treatment with trenboloneacetate and estradiol-17β on skeletal muscle expression and plasma concentrations of oxytocin in sheep. Implantation of trenboloneacetate (TBA) in conjunction with estradiol-17β (E(2)) increases growth, feed conversion efficiency, and carcass leanness in cattle. Our previous study in Brahman steers suggested that the neuropeptide hormone
Effects of an anabolic treatment before puberty with trenboloneacetate-oestradiol or oestradiol alone on growth rate, testicular development and luteinizing hormone and testosterone plasma concentrations. Scrotal circumference, growth and hormonal status after prepubertal anabolic treatments were studied in 18 conventional Belgian White Blue bulls from 3 to 13 mo of age. Young bulls were assigned into three groups: six untreated (control) bulls, six bulls implanted with 140 mg trenboloneacetate + 20 mg oestradiol (Revalor; TBA-E2) and six bulls treated with 45 mg oestradiol (Compudose; E2). Mean scrotal circumference was similar in the three groups at Day O (between 13.0 +/- 0.3 cm to 13.4 +/- 0.7 cm). From Days O to 230, scrotal circumference was strongly inhibited in implanted bulls
Occurrence of trenboloneacetate metabolites in simulated confined animal feeding operation (CAFO) runoff. Metabolites of androgenic synthetic growth promoters used at confined animal feeding operations (CAFOs) pose a demonstrated ecological risk. To evaluate the transport of trenboloneacetate (TBA) metabolites from beef cattle CAFOs, rainfall simulation experiments were conducted
The effect of different implant programs on beef × dairy steer feedlot growth performance and carcass characteristics. The objective of this study was to evaluate potency and timing of trenboloneacetate () administration on live performance and carcass characteristics of beef × dairy steers. A total of 6,895 beef × dairy steers [initial body weight () = 157 ± 5.2 kg] were allotted into 30 pens
Revalor-IH implant [80 mg trenboloneacetate (TBA) and 8 mg estradiol (E)] and a re-implant after a mean of 98-d (± 10.8 SD) with Revalor-200 (200 mg TBA and 20 mg E), or XH - Revalor-XH, a single extended-release implant (200 mg TBA and 20 mg E). Heifers were fed to a baseline endpoint (BASE; pooled mean 166-d ± 11.9 SD), +21, or +42 additional DOF. A total of 10,583 crossbred heifers with mean initial
, Parsippany, NJ) containing equal doses of trenboloneacetate (TBA) and estradiol benzoate (EB): (1) Synovex PLUS (non-coated implant; 200 mg TBA and 28 mg EB; PLUS) or (2) Synovex ONE Feedlot (coated implant; 200 mg TBA and 28 mg EB; ONE-F). Bunks were managed using a slick bunk approach, and all diets contained dry matter (DM) basis 33 mg/kg monensin sodium. All steers were offered access to feed
and liver trace mineral concentrations over 129 d. Steers were stratified by weight into one of four ( = 12 or 13/treatment) implant treatments: (1) estradiol (E2; 25.7 mg E2; Compudose, Elanco Animal Health, Greenfield, IN, USA), (2) trenboloneacetate (TBA; 200 mg TBA; Finaplix-H, Merck Animal Health, Madison, NJ, USA), (3) combination implant (ETBA; 120 mg TBA + 24 mg E2; Revalor-S, Merck Animal Health
Ractopamine and Other Growth-Promoting Compounds in Beef Cattle Operations: Fate and Transport in Feedlot Pens and Adjacent Environments. The current study represents a comprehensive investigation of the occurrence and fates of trenboloneacetate (TBA) and metabolites 17α-trenbolone (17α-TBOH), 17β-TBOH, and trendione (TBO); melengesterol acetate (MGA); and the less commonly studied β
gentleman who was managed as a case of androgenic steroid induced delirium. A 33-year-old gentleman presented with increased aggression, hostility, and destructive impulses. He was a regular user of testosterone propionate, testosterone cyprionate and trenboloneacetate up to 200 mg daily in injectable form. His mental status examination showed labile effect, flight of ideas and persecutory delusions
bodybuilder, with a negative thrombophilia workup, who experienced primary renal infarction while using the AAS trenboloneacetate and testosterone, as well as a subsequent renal infarction while anticoagulated with apixaban. The development of subsequent infarctions in an anticoagulated patient with discontinued recreational steroid use poses a unique situation and challenges the current understanding
Anabolic payout of terminal implant alters adipogenic gene expression of the longissimus muscle in beef steers. This experiment evaluated the dose and payout pattern of trenboloneacetate (TBA) and estradiol-17β (E) on LM mRNA expression of adenosine monophosphate-activated protein kinase-ɑ (-ɑ), β, G protein-coupled receptor 41(), G protein-coupled receptor 43 (), γ, and stearoyl CoA desaturase