Positive predictive value for malignancy of uncertain malignant potential (B3) breast lesions diagnosed on vacuum-assisted biopsy (VAB): is surgical excision still recommended? Breast lesions classified as of "uncertain malignant potential" represent a heterogeneous group of abnormalities with an increased risk of associated malignancy. Clinical management of B3 lesions diagnosed on vacuum
Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons Gap junctions are present in both vertebrates and invertebrates from nematodes to mammals. Although the importance of gap junctions has been documented in many biological processes, the molecular mechanisms underlying gap junction dynamics remain unclear. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics, and loss-of-function in the UNC-44/UNC-33/VAB-8 pathway suppresses the turnover of gap junction channels. Therefore, we first show a signal pathway including ankyrin, CRMP, and kinesin in regulating gap junctions.
Refusal of Breast Surgery in Patients With Breast Cancer With a Clinical Complete Response (cCR) After Neoadjuvant Systemic Therapy and a Confirmed Pathological Complete Response (pCR) Using Vacuum-assisted Biopsy (VAB) and Sentinel Lymph Node Biopsy (SL The main goal of the study is to abandon breast surgery in patients with breast cancer with a clinical complete response (cCR) after neoadjuvant systemic therapy and confirmed pCR using Vacuum-assisted biopsy (VAB) and sentinel lymph node biopsy (SLNB).Evidence of the high diagnostic accuracy (sensitivity and specificity) of vacuum aspiration biopsy in determining pCR in patients with clinical complete response after neoadjuvant systemic therapy will allow abandoning breast surgery in favor of radiation therapy alone, improving the quality
., daily living skills and skills used for interacting socially, and participating in school) * Scores can inform the diagnosis of an intellectual disability and the level of supervision and support required in child care or at school[8] Vineland Adaptive Behavior Scales (VABS)[10]* * Helpful for completing applications for funded support (e.g., Disability tax credit forms) Adaptive Behavior Assessment
) was the procedure of choice, but it is now recommended that needle core biopsy (NCB) or vacuum-assisted biopsy (VAB) is used for assessment of significant screening detected abnormalities.1 This is because current evidence suggests that core biopsy has greater sensitivity and specificity in evaluating microcalcification, asymmetry and architectural distortion than does FNAC. It also aids screening assessment, and on the handling and reporting of biopsy specimens. A similar approach is recommended for symptomatic breast lesions. The document concentrates on NCB and VAB. It also describes the mechanisms used to assess and assure the quality of non-operative diagnosis in breast screening. CEff 090821 6 V2 Final This document constitutes the fifth edition
reflects the opinion of the authors and does not necessarily mirror the perspective and policy of the College of Family Physicians of Canada. 9. Ton J, Perry D, Thomas B, et al. Can Fam Physician. 2020; 66(3):e89-e98. 10. Groen VA, van de Graaf VA, Scholtes VAB, et al. Obes Rev. 2015; 16(2):161–70. 11. Ting R, Allan GM, Lindblad AJ. Tools for Practice #220 online publication. Available at: https
), is designed based on the ventral (temporal) and dorsal (parietal) pathways of the occipital lobe. It is embedded in each Basic Block of the architecture of ResNet18. The VDAB is composed of ventral and dorsal attention blocks. The ventral and dorsal streams detect the structure and location of the pollen grain, respectively. According to the mentioned pathways, the Ventral Attention Block (VAB) extracts
living skills). Adaptive behavior in children with CVI has not been systematically studied, and the relationship between visual function and adaptive function in CVI is unknown. We prospectively recruited 49 children with CVI (mean age, 4 ± 3 years). Adaptive behavior was evaluated using the Vineland Adaptive Behavior Scale, 3rd edition (VABS-III). Visual acuity was assessed by a pediatric neuro -ophthalmologist using the six-level Visual Behavior Scale (VBS). The relationship between VBS and VABS-III scores was assessed using a Spearman correlation coefficient and a multiple regression model to correct for age, sex, and neurologic and ophthalmologic comorbidities. In our cohort, mean adaptive behavior scores in children with CVI were below the 1st percentile on all VABS-III domains and subdomains
of life (HRQOL). Patients younger than 12 months of age who underwent surgical reconstruction of isolated SC between March 2014 and March 2019 with a minimum follow-up period of 3 years were included in this study. The primary outcome was parental satisfaction assessed by PROs. Secondary outcomes were neurocognitive development using the Vineland Adaptive Behavior Scale (VABS), ophthalmological was within the mesocephalic range in 78.22% of the cases. The aesthetic perception of parents and surgeons was concordant in 89.5% of cases. Children of all age groups showed an age-appropriate adaptive level on the VABS (mean score 108.21 ± 9.60). The median HRQOL score was 87.5 (IQR 75-91.66), which was above the normal range. Ophthalmological examinations were unremarkable in all patients. These results
in patients selected with image-guided vacuum assisted biopsy (VAB). This single-arm, prospective, phase 2 nonrandomized clinical trial was conducted at 7 US medical centers and included women 40 years or older with cT1-2N0-1M0 ERBB2-positive (formerly HER2-positive) or triple-negative invasive BC who showed residual breast lesions after NST of less than 2 cm on imaging. Enrollment was from March 6, 2017 , to November 9, 2021. Data analysis was from October to December 2024. Image-guided VAB of the tumor bed (9G with a minimum of 12 cores) was performed after standard NST. Patients with clinically node-negative disease at diagnosis and no residual cancer in the breast on post-NST VAB underwent whole-breast radiotherapy with a boost without breast or axillary surgery. Patients with initial documented nodal
) novel cord blood (CB) intervention in addition to SOC. Input data reflecting behavioral outcomes included baseline Vineland Adaptive Behavior Scale (VABS-3), monthly VABS-3 changes, and CB intervention efficacy on adaptive behavior based on a randomized, placebo-controlled trial (DukeACT). Quality-adjusted life-years (QALYs) were correlated to VABS-3. Costs for children with ASD ($15,791, ages 2-17 years) and adults with ASD ($56,559, ages 18+ years), and the CB intervention (range $15,000-45,000) were incorporated. Alternative CB efficacy and costs were explored. We compared model-projected results to published data on life-expectancy, mean VABS-3 changes, and lifetime costs. Undiscounted lifetime QALYs in the SOC and CB strategies were 40.75 and 40.91. Discounted lifetime costs in the SOC
analysis, patients with (N=151) and without (N=142) pre-arrest comorbidities were evaluated to assess morbidity, survival, and neurologic function following OHCA. No significant difference in 28-day survival was seen between groups. Dependence on technology and neurobehavioral outcomes were assessed among survivors using the Vineland Adaptive Behavior Scales-Second Edition (VABS-II), Pediatric Cerebral Performance Category (PCPC) and Pediatric Overall Performance Category (POPC). Children with pre-existing comorbidities maintained worse neurobehavioral function at twelve months, evidenced by poorer scores on POPC (p=0.016), PCPC (p=0.044), and VABS-II (p=0.020). They were more likely to have a tracheostomy at hospital discharge (p=0.034), require supplemental oxygen at three months (p=0.039) and twelve
Diagnostic Observation Schedule (ADOS-2) and the Vineland Adaptive Behavior Scales (VABS-II) at both the baseline and a follow-up assessment conducted 3 years later. A composite score of social skills was created at baseline and at both time points. Linear regression models were performed to assess the association between difficulties in motor skills and changes in social skills, considering potential confounders such as IQ, age, and gender. The sample included 162 children with ASD. Children with difficulties in global motor skills (N = 114) showed less favorable trajectories in social skills compared to those without motor difficulties. The results were consistent when examining the ADOS-2 and the VABS-II separately. This study provides evidence for the negative impact of difficulties in motor skills
intervention. We recruited 64 children participating in the Early Start Denver Model (ESDM) early intervention program at an Autism Specific Early Learning and Care Center (ASELCC) in Australia. Baseline characteristics across various developmental domains was measured using the Mullen Scales of Early Learning (MSEL), Vineland Adaptive Behaviour Scales, 2nd Edition (VABS-II), and the ESDM Curriculum