of Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, discussed it in the 31st Health Sciences Council VaccineTaskforce (3-24-2022) as follows [14]. There is an immune phenomenon called “original antigenic sin” in English. I think this is the state of immunity given by vaccines etc. with conventional strains, and I think
into care homes the impact can be devastating’.133COVID-19 vaccinesThe COVID-19 vaccination programme has been central to the government’s pandemic response and a broad success so far.134 A vaccinetaskforce was established by government in April 2020 and the first vaccine was approved on 2 December 2020.135 Many people receiving social care were prioritised by government and vaccinated quickly,* though
in schedules with BNT162b2 as a second dose and higher humoral immunogenicity in homologous schedules, but overall lower T-cell responses across all schedules. Future vaccines using these novel platforms might benefit from schedules with long intervals. UK VaccineTaskforce and National Institute for Health and Care Research.
and efficacy testing of forthcoming interventions, 36 volunteers aged 18-29 years without evidence of previous infection or vaccination were inoculated with 10 TCID of a wild-type virus (SARS-CoV-2/human/GBR/484861/2020) intranasally in an open-label, non-randomized study (ClinicalTrials.gov identifier NCT04865237 ; funder, UK VaccineTaskforce). After inoculation, participants were housed in a high
the COVID-19 pandemic, in autumn 2020 the committee gave advice to the recently formed VaccineTaskforce on the groups of people that should be prioritised for vaccination, giving regard to health inequalities.[16][17] Their advice was refined in December of that year.[18]On 6 April 2021, Maggie Wearmouth of the JCVI said "in a personal capacity" that the vaccine roll-out should be slowed "in younger