GEN-RWD Sandbox: bridging the gap between hospital data privacy and external research insights with distributed analytics. Artificial intelligence (AI) has become a pivotal tool in advancing contemporary personalised medicine, with the goal of tailoring treatments to individual patient conditions. This has heightened the demand for access to diverse data from clinical practice and daily life Data (GEN-RWD) Sandbox, a modular multi-agent platform designed for distributed analytics in healthcare. Its primary objective is to empower external researchers to leverage hospital data while upholding privacy and ownership, obviating the need for direct data sharing. Docker compatibility adds an extra layer of flexibility, and scalability is assured through modular design, facilitating
Insights into the Relationship between Temperature Variation and NAPL Removal during In Situ Thermal Remediation of Soil in the Presence of NAPL-Water Co-boiling: A Two-Dimensional Visualized Sandbox Study. Thermal remediation effectively treats sites contaminated with nonaqueous phase liquids (NAPL) by heating soil. A key process is the co-boiling at the water-NAPL interface, which lowers equilibrium zone, a nonequilibrium zone, and an unaffected zone. The temperature data collected by fixed temperature sensors can reflect the spatiotemporal evolution of these zones, offering valuable insights into NAPL removal. This study tackles these challenges using a two-dimensional visualized sandbox integrated with real-time image processing and an array of temperature sensors to monitor the NAPL
Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study. The metagenomic data presented in this article are related to the published research of "A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children" This database contains 16S ribosomal RNA (rRNA) metagenomics of sandbox sand and skin and gut microbiota of children in the intervention and placebo daycares. In intervention daycares, children aged 3-5 years were exposed to playground sand enriched with microbially diverse soil. In placebo daycares, children were exposed to visually similar as in intervention daycares, but microbially poor
How Thailand's tourism industry coped with COVID-19 pandemics: a lesson from the pilot Phuket tourism sandbox project. The Phuket Sandbox project was initiated by collaboration between the central government and support from locals to allow travellers entering Phuket while the country remained in lockdown stage. This initiative has been successful and several lessons could be learned from
Regulatory Sandboxes: A Cure for mHealth Pilotitis? Mobile health (mHealth) and related digital health interventions in the past decade have not always scaled globally as anticipated earlier despite large investments by governments and philanthropic foundations. The implementation of digital health tools has suffered from 2 limitations: (1) the interventions commonly ignore the "law the nation's digital health ecosystem. We call for the inclusion of regulatory sandboxes, as successfully done in the fintech sector, to provide a real-world testing environment for mHealth solutions before deploying them at scale.
Data Validation and Verification Using Blockchain in a Clinical Trial for Breast Cancer: Regulatory Sandbox. The integrity of data in a clinical trial is essential, but the current data management process is too complex and highly labor-intensive. As a result, clinical trials are prone to consuming a lot of budget and time, and there is a risk for human-induced error and data falsification data management using blockchain technology under the regulatory sandbox enabled by the Japanese Cabinet Office. We verified and validated the data in the clinical trial using the validation protocol and tested its resilience to data tampering. The robustness of the system was also proven by survival with zero downtime for clinical data registration during a Amazon Web Services disruption event
MineLoC: A Rapid Production of Lab-on-a-Chip Biosensors Using 3D Printer and the Sandbox Game, Minecraft Here, MineLoC is described as a pipeline developed to generate 3D printable models of master templates for Lab-on-a-Chip (LoC) by using a popular multi-player sandbox game “Minecraft”. The user can draw a simple diagram describing the channels and chambers of the Lab-on-a-Chip
Arcuate stress state in accretionary prisms from real-scale numerical sandbox experiments The stress states in accretionary prisms are important for understanding the building and releasing of seismic energy. Numerous researchers have conducted sandbox experiments as a scaled physical analog model to understand the formation of accretionary prisms. However, measuring stress states in laboratory sandbox experiments is still practically infeasible. Here we performed real-scale numerical sandbox experiments using the discrete element method to understand the 3D stress state in the accretionary prism. Despite the nearly uniform initial conditions, macro-scale undulations of faults, which are similar to those observed in the trenches of an accretionary prism, appear. We reveal
FOXC1, the new player in the cancer sandbox In recent years, rapidly accumulating evidence implicates forkhead box C1 () in cancer, especially in studies of basal-like breast cancer (BLBC). Other studies have followed suit, demonstrating that is not only a major player in this breast cancer subtype, but also in hepatocellular carcinoma (HCC), endometrial cancer, Hodgkin's lymphoma (HL), and non
Heavy metals in sands of sandboxes: health risk associated with their quantities and form of occurrence in some spas of Poland The authors dealt with some hazardous elements, i.e. As, Cd, Co, Cr, Cu, Ni, Pb and Zn, contained in sands of the sandboxes localized in playgrounds of seven spas in southern Poland (CEE). The following determinations were made: the total contents of metals, the most to living organisms contain considerably higher quantities of the metals: from 2.3% TC of Ni to 22.6% TC of As in CaCl-extractable fractions and from 0.7% TC of Cr to 82% TC of As in EDTA-extractable fractions. An assessment of the health risk indicates that children are exposed to the metals present in the sandboxes mostly due to inadvertent swallowing of "dirt" from their hands. The highest are the HQ
The Genomic CDS Sandbox: An Assessment Among Domain Experts Genomics is a promising tool that is becoming more widely available to improve the care and treatment of individuals. While there is much assertion, genomics will most certainly require the use of clinical decision support (CDS) to be fully realized in the routine clinical setting. The National Human Genome Research Institute (NHGRI ) of the National Institutes of Health recently convened an in-person, multi-day meeting on this topic. It was widely recognized that there is a need to promote the innovation and development of resources for genomic CDS such as a CDS sandbox. The purpose of this study was to evaluate a proposed approach for such a genomic CDS sandbox among domain experts and potential users. Survey results indicate a significant
Sharing the sandbox: Evolutionary mechanisms that maintain bacterial cooperation Microbes are now known to participate in an extensive repertoire of cooperative behaviors such as biofilm formation, production of extracellular public-goods, group motility, and higher-ordered multicellular structures. A fundamental question is how these cooperative tasks are maintained in the face of non
Multifractal analysis of weighted networks by a modified sandbox algorithm Complex networks have attracted growing attention in many fields. As a generalization of fractal analysis, multifractal analysis (MFA) is a useful way to systematically describe the spatial heterogeneity of both theoretical and experimental fractal patterns. Some algorithms for MFA of unweighted complex networks have been proposed in the past a few years, including the sandbox (SB) algorithm recently employed by our group. In this paper, a modified SB algorithm (we call it SBw algorithm) is proposed for MFA of weighted networks. First, we use the SBw algorithm to study the multifractal property of two families of weighted fractal networks (WFNs): "Sierpinski" WFNs and "Cantor dust" WFNs. We also discuss how the fractal
Playing with curricular milestones in the educational sandbox: Q-sort results from an internal medicine educational collaborative. In competency-based medical education, the focus of assessment is on learner demonstration of predefined outcomes or competencies. One strategy being used in internal medicine (IM) is applying curricular milestones to assessment and reporting milestones to competence
authorisations every 5 years; refusing the general roll-out of an assessment method for emergency situations, trialled during the covid-19 pandemic; and refusing the institutionalisation of a very high-level exemption from the legislation, referred to as a regulatory “sandbox”, which would allow the EMA to bypass the European legislative process entirely (5). However, a number of important points were