"testosterone propionate" from_date:2012

Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling Androgen plays a pivotal role in the progression of renal fibrosis. However, whether exogenous androgen treatment to aged male rats can improve the age-related renal fibrosis was not explored. In our study, the changes of morphological tested in kidney of aged male Wistar rats after subcutaneous testosterone propionate (TP, 2 mg/kg/d, 84-day) injection. Aged rats showed significantly renal histopathological changes, increased renal fibrosis, increased thickening of the glomerular basement membrane and the Bowman's capsule basement membrane, declined renal functional, increased ECM, lower expressions of MMP-2 and MMP-9 and higher

Inhibitory effects of Pycnogenol®, a pine bark extract, in a rat model of testosterone propionate-induced benign prostatic hyperplasia Benign prostate hyperplasia (BPH) is a male reproductive disease that has gained increasing importance in recent years. The present study investigated whether Pycnogenol® (PYC), a standardized French maritime pine bark extract, could prevent BPH induced by testosterone propionate (TP) in rats. Male Sprague-Dawley rats were randomly divided into five groups of six rats. One group was used as a normal control rats and the other groups received subcutaneous injections of TP for 4 weeks to induce BPH. In the two treatment groups, PYC (20 or 40 mg/kg) was administered daily for 4 weeks by oral gavage concurrently with the induction of TP. All rats were sacrificed

Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats There is a controversy over the effects of testosterone supplements on dopaminergic function. Both neuroprotective and toxic effects of testosterone supplements are reported. The status of oxidative stress seems to explain the neuroprotective or toxic properties of testosterone. To determine the efficacy of testosterone supplements in different status of oxidative stress, the present studies analyzed the dopamine (DA)-related behaviors and neurochemical indices, as well as markers of nigrostriatal dopaminergic (NSDA) system in reserpine-treated aged male rats followed by testosterone propionate (TP) supplements. The status of oxidative stress

Polycystic ovary syndrome induced by exposure to testosterone propionate and effects of sympathectomy on the persistence of the syndrome

Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate. The effects of testosterone propionate (TP) supplements on the coordinated motor behavior and nigrostriatal dopaminergic (NSDA) system were analyzed in aged male rats. The present study showed the coordinated

Gene expression profile of the neonatal female mouse brain after administration of testosterone propionate. Clinical care decisions for peripubertal adolescents with gender dysphoria (GD) should be made carefully. Furthermore, the identification of biomarkers is very important for rapid and accurate diagnosis of GD in young people. The aim of this study was to investigate gene expression profiles during masculinization of the neonatal female mouse brain by testosterone and to identify biomarkers related to GD. Microarray analysis was performed using RNAs extracted from the brains of neonatal mice treated by intraperitoneal injection of testosterone propionate during the sexual determination period. Sequence motif enrichment analysis for sex hormone receptor responsive elements

preparations of compounded bioidentical menopausal hormone therapy include estrone, estradiol cypionate, estriol, pregnenolone, testosterone, testosterone cypionate, and testosterone propionate 1. Many compounding pharmacies use the phrase “bioidentical hormone” as a marketing term to imply that these preparations are natural and, thus, safer and more effective than FDA-approved menopausal medications

There are no testosterone preparations licensed for children in the UK. However, the following are licensed in the UK for adults and are used in children off-label: Sustanon 250®, testosterone enantate, Nebido® and all testosterone gels. There are other testosterone preparations that are unlicensed in the UK for any age group or indication, including testosterone propionate and Andractim® gel. Micropenis in infancy Intramuscular Topical Preparation Testosterone enantate, Sustanon 250®, testosterone propionate Testosterone 1-5% cream Dose 25mg 1 application Frequency Monthly (weekly for testosterone propionate) Three times daily Duration 3 months 3-6 weeks See also notes within the text Intramuscular • Preferred preparation - Testosterone enantate or Sustanon 250® (for neonates <28 days, can only use testosterone

1000 mg/4 ml. Sustanon® ‘250’ 1 ml ampoule consists of testosterone propionate (30 mg), testosterone phenylpropionate (60 mg), testosterone isocaproate (60 mg) and testosterone decanoate (100 mg).Both medicinal products are registered as supplement therapy for hypogonadism in men, when testosterone deficiency has been confirmed based on clinical characteristics and biochemical tests.National Health

The Effects of Chronic Administration of Testosterone Propionate with or without Estradiol on the Sexual Behavior and Plasma Steroid Levels of Aged Female Rats. Low sexual desire concomitant with feelings of distress is reported in naturally and surgically menopausal women. A combination of estradiol (E2) and testosterone (T) restores sexual desire and interest in these women. The central mechanisms by which E2 and T act to restore desire are poorly understood. Here we examined the effect of chronic treatment with testosterone propionate (TP) administered by a sc SILASTIC brand capsule in aged ovary-intact female rats. Females were first treated with TP alone, followed by a second phase when TP was administered in combination with estradiol benzoate (EB; 10 μg) by sc injection 48 h prior

investigation AIM OF THE STUDY: To establish an integrated strategy to uncover the mechanisms underlying the potential active ingredients and therapeutic targets in complex TCM emplastra, using YSG for BPH treatment as a case study. A BPH rat model was established via castration and testosterone propionate injections. The therapeutic efficacy of YSG was evaluated comprehensively through phenotypic

at different doses in a castrated New Zealand rabbit model of bulbar urethroplasty. Fifteen castrated and five non-castrated adult male New Zealand rabbits were randomized into four groups: non-castrated control (NC), castrated control (0 mg/kg), physiological dose (2.5 mg/kg), and supraphysiological dose (5 mg/kg) of testosterone propionate. All rabbits underwent bulbar urethroplasty via end-to-end

on hair growth promotion in AGA mice and to explore the active components and mechanism. Testosterone propionate was administered subcutaneously to mice to establish an AGA mouse model. The therapeutic effects of CZX on AGA were evaluated by observing skin colour changes, hair growth time, and average hair length; calculating the hair growth score; and performing skin histopathological analysis

to epithelial proliferation, inflammation, deranged redox balance, and apoptosis. Diacerein (DIA), the anthraquinone derivative, is a non-steroidal anti-inflammatory drug. This study intended to investigate the ameliorative effect of DIA on the prostatic histology in testosterone-induced BPH in rats. BPH was experimentally induced by daily subcutaneous injection of testosterone propionate for four weeks

in male rodents. The results of the present study showed that the neonatal administration of letrozole (LET), a nonsteroidal aromatase inhibitor, within 2 h of birth rescued AVPV Kiss1 expression and the LH surge in adult male rats, while the neonatal administration of testosterone propionate (TP) irreversibly attenuated AVPV Kiss1 expression and the LH surge in adult female rats. Furthermore

Hyperplasia (BPH). However, the mechanisms underlying this effect are remained indistinct. This study aimed to clarify potential therapeutic mechanisms of herb pair on BPH from a metabolic perspective. Testosterone propionate-induced BPH rat model was established, prostatic parameters, histopathology and the levels of serum dihydrotestosterone (DHT) and testosterone (T) were used to evaluate