Alpha-adrenergicAgonists for the Management of Opioid Withdrawal HomeReviewsTherapy (NNT) ReviewsDiagnosis (LR) ReviewsAboutThe NNT, ExplainedThe NNT Rating SystemtheNNT Editorial ProcessThe NNT Intervention QuizAbout theNNT TeamSubmit an articleAccountLoginSign upContactDONATEAlpha-adrenergic Agonists for the Management of Opioid Withdrawal3 to prevent one episode of severe withdrawalBenefits factors (drug prescribing regulations, dislike for the prolonged nature of methadone withdrawal, and desire to find alternatives for opiate treatment) led to the investigation of alpha-adrenergicagonists (AAAs) to decrease the severity of withdrawal symptoms.2A Cochrane review, including 26 randomized controlled trials totaling 1,728 participants, sought to compare AAAs vs. methadone and AAAs vs
Effect of Low-Concentration, Nonmydriatic Selective Alpha-AdrenergicAgonist Eyedrops on Upper Eyelid Position. Ptosis after botulinum toxin injection is a disturbing complication. Decongestant and antiglaucoma eyedrops are frequently prescribed for temporary improvement of eyelid ptosis. Although frequently cited on informal communications, the effect of these drugs on eyelid position has never
Identification of alpha-adrenergicagonists as potential therapeutic agents for dermatomyositis through drug-repurposing using public expression datasets
are instructed to present to ED within two hours of onset as there is a risk of irreversible damage if fulminant priapism lasts for longer than four hours. Management of priapism can include more conservative measures such as gentle exercise, analgesia, hydration, bladder emptying/passing urine, warmth and alpha-adrenergicagonist (e.g. etilefrine 15mg 6-hourly, maximum dose 60mg in 24 hours). Cold compresses
Effect of phenylephrine infusion on postpartum blood loss after cesarean delivery: A Placebo-controlled, randomized clinical trial. Preclinical studies have documented the role of alpha-adrenergicagonists in myometrial contraction. Phenylephrine is frequently used to prevent and treat post-spinal hypotension during cesarean delivery. We hypothesized phenylephrine would reduce postpartum blood
* anticholinergic use * antidepressant use * antipsychotic use * alpha-adrenergicagonist use * calcium-channel blocker useMore risk factorsLog in or subscribe to access all of BMJ Best PracticeDiagnostic investigations1st investigations to order * empty supine stress test * urinalysis * post-void residual measurement * cough stress testMore 1st investigations to orderInvestigations to consider * pad test
* anticholinergic use * antidepressant use * antipsychotic use * alpha-adrenergicagonist use * calcium-channel blocker useMore risk factorsLog in or subscribe to access all of BMJ Best PracticeDiagnostic investigations1st investigations to order * empty supine stress test * urinalysis * post-void residual measurement * cough stress testMore 1st investigations to orderInvestigations to consider * pad test
Intraoperative clonidine in endometriosis and spine surgery: A protocol for two randomised, blinded, placebo-controlled trials. A high proportion of patients who undergo surgery continue to suffer from moderate to severe pain in the early postoperative period despite advances in pain management strategies. Previous studies suggest that clonidine, an alphaadrenergicagonist, administered during
Stress response during early sedation with dexmedetomidine compared with usual-care in ventilated critically ill patients. Sedative agents may variably impact the stress response. Dexmedetomidine is a sympatholytic alpha-adrenergicagonist mainly used as a second-line sedative agent in mechanically ventilated patients. We hypothesised that early sedation with dexmedetomidine as the primary agent