, Amiphenazole, Brecanavir, Carumonam, Cefepime, and Cefmatilen. Ethyl cyanoacetate reacted with phenylisothiocyanate, chloroacetone, in two different basic mediums to afford the thiazole derivative 6, which reacted with dimethylformamide- dimethyl acetal in the presence of DMF to afford the unexpected thiazole derivative 11. The structures of the thiazoles 6 and 11 were optimized using B3LYP/6-31G(d,p) method
Antagonists of morphine-induced respiratory depression. A study in postoperative patients. This double blind study showed the effect of four drugs, levallorphan, naloxone, doxapram and amiphenazole, an opiate-induced analgesia and respiratory depression. Satisfactory analgesia was induced by administration of morphine intravenously in a dose of up to 0.33 mg/kg; such a dose, however, produced significant depression of respiration. Administration of levallorphan, naloxone, and amiphenazole produced reversal of respiratory depression and analgesia. Doxapram reversed the respiratory depression but did not alter analgesia.
[Continuous monitoring of spontaneous postoperative respiration. 3. The effect of amiphenazole on cutaneous oxygen and carbon dioxide partial pressure following gynecologic surgery under halothane anesthesia]. In an attempt to verify non-invasive respiratory monitoring for patients in the early postoperative period, cutaneous O2 and CO2 pressures were monitored in 30 female patients recovering from major gynaecologic surgery under halothane anaesthesia. In a double-blind and randomized fashion, in the recovery room the patients received a single intravenous bolus injection of placebo or 150 mg amiphenazole, a respiratory stimulant. The data were collected and stored in a personal computer, using the TCM3 system with a combination electrode for simultaneous measuring of cutaneous oxygen
it was 39-89 times more potent. The potencies depended on the test situation and the species of animal used.4. In animals pretreated with amiphenazole or tacrine, the analgesic activities of morphine and morphine-N-oxide were increased. The potencies of these analgesic drugs given intraperitoneally were increased to a greater extent than were the potencies obtained by subcutaneous administration.5 . A possible explanation for the increase in analgesic potency of morphine-N-oxide produced by pretreatment with amiphenazole or tacrine may be that morphine-N-oxide is rapidly inactivated in the liver and this inactivation is impaired by amiphenazole and tacrine.
-arterial injection of the central stimulant drugs leptazol, bemegride, amiphenazole and 5-(1,3-dimethylbut-2-enyl)-5-ethylbarbituric acid (McN 481) also depressed ganglionic transmission. Leptazol or bemegride did not antagonize the ganglion-blocking action of amylobarbitone or troxidone. The intra-arterial injection of pecazine and perphenazine, and the intravenous injection of barbitone, benactyzine