"Amphetamine dependence"

Cue reactivity and opioid blockade in amphetamine dependence: A randomized, controlled fMRI study. The opioid antagonist, naltrexone, has been shown to reduce the risk of relapse in amphetamine dependence, but the mechanisms behind this effect are not well understood. We aimed to investigate if naltrexone attenuates cue reactivity and craving in amphetamine dependence. Forty men with severe , intravenous amphetamine dependence were randomized to one dose of naltrexone (50 mg) or placebo. In a BOLD fMRI cue reactivity paradigm, they were exposed to drug-related and neutral films and gave subjective ratings of craving after each film. Twenty-nine patients left data of sufficient quality to be included in the final analysis. The drug-related films elicited strong subjective craving and BOLD

Extended-Release Injectable Naltrexone (XR-NTX) With Intensive Psychosocial Therapy for Amphetamine-Dependent Persons Seeking Treatment: A Placebo-Controlled Trial. Explore the efficacy of extended-release injectable naltrexone (XR-NTX) for preventing relapse to amphetamine use. Clinical trial of 100 amphetamine-dependent, treatment-seeking patients who were randomized to 6 monthly 380 mg doses of XR-NTX or matching placebo before entering intensive outpatient after varying lengths of inpatient treatment in Reykjavik, Iceland. Weekly urine drug tests, retention, and standardized instruments assessed efficacy. Of 169 approached, 100 were randomized. Although amphetamine dependence was the main reason for seeking treatment, three-quarters or more of participants had 1 or more other substance

The risk and protective factors for amphetamine consumption among adult male amphetamine dependent: A systematic review PROSPERO International prospective register of systematic reviews Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms

PTSD Risk Associated with a Functional DRD2 Polymorphism in Heroin Dependent Cases and Controls is Limited to Amphetamine Dependent Individuals Posttraumatic stress disorder (PTSD), a pathologic response to severe stress, is a common co-morbid disorder in substance-dependent individuals. Evidence from twin studies suggests that PTSD is moderately heritable. Genetic association studies to date . The top hits include SNPs from other dopaminergic system genes: DRD2 DRD3, TH and DBH. Additional analyses revealed that the association involving rs12364283 is largely limited to amphetamine-dependent individuals. Substantial risk is observed in amphetamine-dependent individuals, with at least one copy of this SNP [OR 2.86 (1.92-4.27); P = 2.6 × 10(-7) ]. Further analyses do not support extensive

in the number of patients using meth/amphetamine at baseline and six-month follow-up. Among those with meth/amphetamine dependence at baseline there was a decrease in the number of days using, but no significant change in quantity used per day. The second study examining the IDAT program12 again found some positive outcomes for alcohol use at the six-month follow-up. Among the small sample of 40 IDAT patients

, Acheson LS, Lintzeris N, Ezard N. Pharmacological treatment of methamphetamine/amphetamine dependence: A systematic review. CNS Drugs. 2020;34(4):337–65. 19. Caruana EJ, Roman M, Hernández-Sánchez J, Solli P. Longitudinal studies. Journal of Thoracic Disease. 2015;7(11):E537. 20. Wang X, Cheng Z. Cross-sectional studies: Strengths, weaknesses, and recommendations. Chest. 2020;158(1):S65–S71. 21. Measham

The Timing of Clinical Effects of Bupropion Misuse Via Insufflation Reported to a Regional Poison Center. Bupropion is an antidepressant medication with expanding indications including smoking cessation, weight loss, attention-deficit/hyperactivity disorder, seasonal affective disorder, and amphetamine dependence. Despite its increasing popularity among providers, it has a well-known narrow

for amphetamine psychosis. Cochrane Database Syst Rev. 2009 Jan 21(1):CD003026.Lee NK, Rawson RA; A systematic review of cognitive and behavioural therapies for methamphetamine dependence. Drug Alcohol Rev. 2008 May27(3):309-17.Srisurapanont M, Jarusuraisin N, Kittirattanapaiboon P; Treatment for amphetamine dependence and abuse. Cochrane Database Syst Rev. 2001Darke S, Kaye S, McKetin R, et al; Major physical

dependence ( = 64), "pure" amphetamine dependence ( = 51), or polysubstance dependence ( = 89), or had no history of substance dependence ( = 133). Decision-making was assessed via two neurocognitive tasks: (1) the Iowa Gambling Task (IGT), a measure of decision-making under ambiguity (i.e., uncertain risk contingencies); and (2) the Cambridge Gambling task (CGT), a measure of decision-making under risk

models were used to examine in-hospital mortality and length of stay. Analysis of these data was conducted from November 2017 to August 2018. Amphetamine dependence or abuse or amphetamine poisoning. Annual hospitalizations, in-hospital mortality, length of stay, transfer to another facility, and costs. Over the 2003 to 2015 study period, there were 1 292 300 weighted amphetamine-related

") OR ("Amphetamine-Related Disorders” OR "Disorder, Amphetamine-Related" OR "Disorders, Amphetamine-Related" OR "Amphetamine Abuse" OR “Amphetamine” OR "Abuse, Amphetamine" OR "Amphetamine Addiction" OR "Addiction, Amphetamine" OR "Amphetamine Dependence" OR "Dependence, Amphetamine" OR "n-methyl-3, 4-methylenedioxyamphetamine” OR "N Methyl 3, 4 methylenedioxyamphetamine" OR "MDMA

studiedStimulant use disorder or dependence; i.e. cocaine, amphetamine or methamphetamine use disorder or dependence.Participants/populationInclusion: Adults with cocaine or (meth)amphetamine dependence (DSM-IV), or a stimulant use disorder (DSM-5), or diagnosed using any other recognised diagnostic system (e.g., ICD-11).Exclusion: NoneIntervention(s), exposure(s)'prescription amphetamines', including

The Anorexigenic Peptide Neuromedin U (NMU) Attenuates Amphetamine-Induced Locomotor Stimulation, Accumbal Dopamine Release and Expression of Conditioned Place Preference in Mice Amphetamine dependence, besides its substantial economical consequence, is a serious cause of mortality and morbidity. By investigations of the neurochemical correlates through which addictive drugs, such as amphetamine . Thirdly, we demonstrated that NMU administration into the NAc block the ability of amphetamine to cause a locomotor stimulation in mice. However, accumbal NMU administration did not attenuate the amphetamine-induced expression of CPP in mice. Our novel data suggest that central NMU signalling is involved in development of amphetamine dependence.

drug users. The goal of the current study was to identify multivariate substance-specific markers classifying heroin dependence (HD) and amphetamine dependence (AD), by using machine-learning approaches. Participants included 39 amphetamine mono-dependent, 44 heroin mono-dependent, 58 polysubstance dependent, and 81 non-substance dependent individuals. The majority of substance dependent participants

depression and anxiety as confounding variables. This study was conducted in Mashhad, Iran. Ninety amphetamine dependent patients, who were admitted in residential centers during 2012-2014 and met our inclusion criteria, were chosen by purposive nonprobability sampling method. Sleep quality was assessed by Pittsburg sleep questionnaire, in the first, second, and after the fourth week of abstinence