Angiolymphoidhyperplasia with eosinophilia responded well to dupilumab in two cases. Angiolymphoidhyperplasia with eosinophilia (ALHE) is a rare, benign vasoproliferative skin disorder. The overall efficacy of current treatments remains suboptimal with frequent recurrence. Recent studies have suggested the type-2 inflammation features of ALHE and emphasized the role of T cells, which calls
Percutaneous ethanol sclerotherapy is a promising treatment for recalcitrant angiolymphoidhyperplasia with eosinophilia. Angiolymphoidhyperplasia with eosinophilia (ALHE) is a rare benign vascular proliferation, which manifests as characteristic red nodules and papules, mostly located on the scalp and periauricular regions. Patients seek treatment for both aesthetic and functional reasons
Angiolymphoidhyperplasia with eosinophilia of the external ear. Herein we present the rare case of angiolymphoidhyperplasia with eosinophilia of the external ear treated by surgical resection and full-thickness skin graft. Current diagnosis and management options are reviewed.
Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoidhyperplasia with eosinophiliaAngiolymphoidhyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still
Angiolymphoidhyperplasia with eosinophilia (epithelioid hemangioma) of the external auditory canal, an unusual presentation in an adult female: a case report Angiolymphoidhyperplasia with eosinophilia (ALHE) is a rare entity that usually occurs as 0.5-3 cm, pink-to-brown nodules on the skin surface and subcutaneous tissues of the head and neck (Al-Muharraqi MA, Faqi MK, Uddin F, Ladak K , Darwish A. Angiolymphoidhyperplasia with eosinophilia (epithelioid hemangioma) of the face: an unusual presentation. Int J Surg Case Rep 2011;2:258-60.; Suzuki H, Hatamochi A, Horie M, Suzuki T, Yamazaki S. A case of angiolymphoidhyperplasia with eosinophilia (ALHE) of the upper lip. J Dermatol 2005; 32:991-5.). A 29-year-old woman presented to our ENT (ear-nose-throat) clinic with multiple, small
Novel Application of 32P Brachytherapy: Treatment of AngiolymphoidHyperplasia with Eosinophilia in the Right Auricle with 8-Year Follow-Up Angiolymphoidhyperplasia with eosinophilia (ALHE) is a distinctive benign vascular disease that can be challenging to treat due to inconsistent results for various treatment modalities such as surgical excision, corticosteroids, radiotherapy, laser therapy
Angiolymphoidhyperplasia with eosinophilia: a case report Angiolymphoidhyperplasia with eosinophilia is a benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate. Mostly, it affects middle-aged adults manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area. In this case, we report a 13-year-old Caucasian girl with bilateral, huge, protruding, and yellowish nostril masses which were peculiar in location and of gross appearance. At first, the disease proved to be a diagnostic dilemma. After making a diagnosis of angiolymphoidhyperplasia with eosinophilia, the disease also proved to be a therapeutic dilemma. It did not respond to oral prednisolone or to oral indomethacin
VEGF-A Links AngiolymphoidHyperplasia With Eosinophilia (ALHE) to THSD7A Membranous Nephropathy: A Report of 2 Cases. Autoantibodies against thrombospondin type 1 domain-containing 7A (THSD7A) cause membranous nephropathy (MN); however, the mechanisms involved in THSD7A expression and immunization are uncertain. We present 2 cases of THSD7A-associated MN accompanied by angiolymphoidhyperplasia with eosinophilia (ALHE), a benign tumor characterized by proliferation of plump endothelial cells. Prednisolone therapy, but not surgical resection of ALHE tumors, successfully suppressed eosinophilia and proteinuria in both cases. Because ALHE is characterized by the proliferation of plump endothelial cells, we focused on the roles of vascular endothelial growth factor A (VEGF-A) in MN pathogenesis. We found
Angiolymphoidhyperplasia with eosinophilia: report of nine cases. Angiolymphoidhyperplasia with eosinophilia (ALHE) is a benign vascular proliferation characterized by dermal or subcutaneous red or brown papules or nodules, most commonly on the head and neck. The aim of this study was to review the epidemiological and clinical characteristics of ALHE, focusing particularly on the histological was formed mainly of lymphocytes and eosinophils with isolated plasma cells and histiocytes. Surgery was the most common treatment in our series. Other local or general treatment has also been used with varying responses. Angiolymphoidhyperplasia with eosinophilia is a rare epithelioid vascular tumor with a challenging clinical and histological diagnosis. Despite its benign nature, ALHE causes
Angiolymphoidhyperplasia with eosinophilia involving the common digital artery of the hand: A case report and classification of upper limb lesions Angiolymphoidhyperplasia with eosinophilia (ALHE) is a rare benign reactive inflammatory lesion. The usual presentation is a single or multiple skin nodules of the head and neck. Involvement of the hand is very rare and there have been
Solitary nodule of angiolymphoidhyperplasia with eosinophilia of the back masquerading as pyogenic granuloma Angiolymphoidhyperplasia with eosinophilia (ALHE) is a rare chronic inflammatory disorder of unknown etiology that most commonly presents as painless lymphadenopathy or subcutaneous masses in the head and neck region. The pathogenesis of the disease is not yet clear. The differential
AngiolymphoidHyperplasia with Eosinophilia Involving the Occipital Artery: Case Report and Review of Literature AngiolymphoidHyperplasia with Eosinophilia (ALHE) is an atypical vascular tumour occurring primarily in the head and neck area, which must be distinguished from Kimura's disease. The lesions can appear as single or multiple grouped intradermal papules or subcutaneous nodules. We
Ophthalmic Manifestations of AngiolymphoidHyperplasia with Eosinophilia: A Systematic Review PROSPERO International prospective register of systematic reviews Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied
Human polyomavirus-6 infecting lymph nodes of a patient with an angiolymphoidhyperplasia with eosinophilia or Kimura disease. Human polyomavirus 6 (HPyV6) is most often detected at the skin surface of healthy individuals. Here, we demonstrate for the first time that HPyV6 also infects internal tissues. We provide direct evidence of HPyV6 infecting a lymph node of a patient with an angiolymphoidhyperplasia with eosinophilia or Kimura disease.
AngiolymphoidHyperplasia With Eosinophilia Within a Vascular Malformation: Case Report and Review of the Literature. Angiolymphoidhyperplasia with eosinophilia (ALHE) is a rare, benign microvascular proliferation tumor. The etiology of ALHE is unknown, though some hypothesize it occurs in reaction to focal trauma. This study presents a case of AHLE within a vascular malformation, its treatment
Angiolymphoidhyperplasia with eosinophilia and entrapment of the ulnar nerve The angiolymphoidhyperplasia with eosinophilia (ALHE) is a sporadic vasoproliferative lesion of uncertain etiology involving the skin and the subcutaneous tissue. Occasionally, it involves also the large arteries compressing the near nerves. ALHE is commonly confused with Kimura's disease because of their clinical
Angiolymphoidhyperplasia with eosinophilia in the angle region of the mandible Angiolymphoidhyperplasia with eosinophilia (ALHE), also called epithelioid hemangioma, is a rare benign vascular lesion usually affecting the muscular arteries of the head and neck in female patients. Here, we report a 30-year-old male patient who presented with painless swelling in the angle region of the mandible
AngiolymphoidHyperplasia with Eosinophilia: A Case Report Angiolymphoidhyperplasia with eosinophilia is a rare disease considered as being a vascular malformation resulting from a subjacent arteriovenous shunt. It affects mostly the head of women between 20 and 40 years old and may present spontaneous involution.
AngiolymphoidHyperplasia With Eosinophilia of the Orbit and Ocular Adnexa: Report of 5 Cases. To report the clinical and histopathologic findings of ocular adnexal angiolymphoidhyperplasia with eosinophilia, an unusual but often misdiagnosed benign disorder. The ophthalmologic findings of angiolymphoidhyperplasia with eosinophilia with ocular adnexal involvement are variable and include eosinophils, lymphocytes, and plasma cells. Angiolymphoidhyperplasia with eosinophilia is a rare disease that can affect the ocular adnexal tissue. The clinical presentation is often nonspecific; therefore, histopathologic studies are essential for diagnosis and subsequent management of this benign condition.