Intraocular Lenses for Infants with Aphakia Skip to main contentAboutCollaboration/OutreachPatient/CommunityCareersContactMy CADTHFRReportsResourcesProvide InputSubmit a RequestNews & EventsWhat Does The Evidence Say About...SearchBreadcrumbHome Intraocular Lenses for Infants with AphakiaCopied to clipboardIntraocular Lenses for Infants with Aphakia( Last Updated : March 31, 2022)Project Status:CompleteProject Line:Health Technology ReviewProject Sub Line:Systematic ReviewProject Number:RE0036-000DetailsAphakia is the absence of the lens of the eye due to surgical removal, a perforating wound or ulcer, or congenital anomaly. Interventions for optical correction of aphakia include external devices, such as glasses or contact lenses, and intraocular lens (IOL) implantation, which offers a permanent
Sir Harold Ridley (1906-2001) and his cure for aphakia: new historical insights into the invention of the intraocular lens. Harold Ridley (1906-2001) is widely known as the person who developed and implanted the first intraocular lens, but some details of this early event have been unknown or misunderstood. Historical review. Historical documents were reviewed, including contemporaneous journal
Modified technique for sutured scleral fixated intraocular lens in a patient with post-traumatic aniridia and aphakia: a case report. A modified surgical technique of sutured scleral fixated intraocular lens (SSF-IOL) was applied in a patient with post-traumatic aniridia and aphakia. A 51-year-old man was referred to our clinic with decreased vision (finger count) in his right eye. This patient were observed. The modified SSF-IOL technique can offer improved visual quality for patients with aniridia and aphakia by ensuring proper IOL positioning and reducing astigmatism.
Complications, Visual Acuity, and Refractive Error Three Years After Secondary Intraocular Lens implantation for Pediatric Aphakia. To report the cumulative incidence of complications and describe refractive error and visual acuity (VA) outcomes in children undergoing secondary intraocular lens (IOL) implantation following previous surgery for non-traumatic cataract. Pediatric cataract registry
Refractive change at 5 years in the Toddler Aphakia and Pseudophakia Study (TAPS). To report refractive change at age 5 years in pseudophakic eyes operated before 2 years of age. Retrospective case series at 10 Infant Aphakia Treatment Study (IATS) sites. Children who underwent cataract surgery with primary intraocular lens placement during the IATS enrollment years, including infants 1 to <7
Transcorneal Intravitreal Injection Technique for Pediatric Patients with Aphakia and Post-vitrectomized Eyes. BACKGROUND Although modern minimally invasive vitreoretinal surgery has improved visual outcomes, post-operative proliferative vitreoretinopathy (PVR) and hypotony remain a cause of poor visual results1,2. The migration and proliferation of retinal pigment epithelial cells
What we have learned from the Infant Aphakia Treatment Study: The 49th Annual Frank D. Costenbader Lecture. Unilateral congenital cataracts lead to deprivation amblyopia, which can be severe. Until the 1970s, they were believed to be always associated with poor visual outcomes. However, advances in our understanding of the plasticity of the infant brain and the development of better surgical techniques allowed good visual outcomes to be obtained in a few of these patients. The Infant Aphakia Treatment Study (IATS) was conducted to provide empirical evidence regarding the best type of optical correction to be used following surgical extraction of the cataract. Specifically, infants were randomly assigned to either be left aphakic and to wear contact lenses or an intraocular lens (IOL
Effective lens position and pseudophakic refraction prediction error at 10½ years of age in the Infant Aphakia Treatment Study. The refraction prediction error (PE) for infants with intraocular lens (IOL) implantation is large, possibly related to an effective lens position (ELP) that is different than in adult eyes. If these eyes still have nonadult ELPs as they age, this could result in persistently large PE. We aimed to determine whether ELP or biometry at age 10½ years correlated with PE in children enrolled in the Infant Aphakia Treatment Study (IATS). We compared the measured refraction of eyes randomized to primary IOL implantation to the "predicted refraction" calculated by the Holladay 1 formula, based on biometry at age 10½ years. Eyes with incomplete data or IOL exchange were
In-the-Bag Versus Ciliary Sulcus Secondary Intraocular Lens Implantation for Pediatric Aphakia: A Prospective Comparative Study. To compare outcomes of in-the-bag vs ciliary sulcus secondary intraocular lens (IOL) implantation for pediatric aphakia. Prospective interventional case series. This institutional study was conducted in 202 children (355 aphakic eyes) diagnosed as having congenital that in the sulcus group (logMAR, 0.56 vs 0.67, P = .014). Compared with ciliary sulcus secondary IOL implantation, in-the-bag IOL implantation reduced AEs and yielded better IOL centration and BCVA for pediatric aphakia.
Angle closure secondary to lens remnants in a patient with presumed aphakia: case report. Eyes with a short axial length or anterior chamber depth often develop narrowed anterior chamber angles in association with an enlarging crystalline lens. We report a case of a patient who presented in angle closure, with a distant history of prior intervention for congenital cataracts and was presumed to be aphakic. A 78-year-old male presented with acute onset unilateral eye pain and blurred vision. He was found to have increased intraocular pressure, anteriorly bowed iris, and angle closure. Despite prior documentation of aphakia after treatment for congenital cataracts, detailed workup revealed residual crystalline lens material pushing the peripheral iris anteriorly. Further history confirmed
Primary aphakia: clinical recognition is the key to diagnosis. To describe the presentation and treatment outcomes of a cohort of children with primary aphakia (PA). Clinical photographs and ultrasound biomicroscopy (UBM) images of children presenting with sclerocornea and undetermined anterior segment dysgenesis between July 2017 and December 2020 were reviewed retrospectively. Children who had no crystalline lens visible on UBM were included. A total of 124 UBM images were captured for 124 children with cloudy corneas. Twelve children were identified with congenital primary aphakia: 5 had bilateral buphthalmos, 2 had buphthalmos in one eye and microphthalmos in the other, and 5 had bilateral sclerocornea-microphthalmia complex. All patients had a peculiar silvery-blue corneal appearance, with fine
The accuracy of intraocular lens calculation varies by age in the Infant Aphakia Treatment Study. Refraction predictions from intraocular lens (IOL) calculation formulae are inaccurate in children. We sought to quantify the relationship between age and prediction error using a model derived from the biometry measurements of children enrolled in the Infant Aphakia Treatment Study (IATS) when
Congenital primary aphakia. To describe the natural history, management, and visual outcome in children with congenital primary aphakia (CPA). This is a multicenter retrospective consecutive case series from five academic centers in England and North America. A total of 27 eyes of 14 patients were included (male:female, 1.7:1). Thirteen patients had bilateral CPA, and 1 patient had unilateral
Intraocular lens implantation with flattened flanged intrascleral fixation technique in pediatric aphakia. To evaluate the clinical outcomes of flattened flanged intrascleral fixation of the intraocular lens (IOL) in cases of pediatric aphakia without adequate capsular support. The medical records of children who underwent flattened flanged intrascleral IOL implantation for aphakia
Myopic Shift at 10-Year Follow-up in the Infant Aphakia Treatment Study. We studied the myopic shift and anisometropia at 10.6 (+/−0.3) years of age in the Infant Aphakia Treatment Study. We found myopic shift continues in the operated eye from 5-10.5 years at a lower rate than that prior to age five years while anisometropia increases proportionally.
Long-term strabismus outcomes after unilateral infantile cataract surgery in the Infant Aphakia Treatment Study. To characterize long-term strabismus outcomes in children in the Infant Aphakia Treatment Study (IATS). This study was a secondary data analysis of long-term ocular alignment characteristics of children aged 10.5 years who had previously been enrolled in a randomized clinical trial 45/55 [82%]; P = 0.8). Median visual acuity in the study eye was 0.56 logMAR (20/72) for children with orthotropia or microtropia <10 versus 1.30 logMAR (20/400) for strabismus ≥10 (P = 0.0003). Strabismus-in particular, exotropia-is common irrespective of aphakia management 10 years following infant monocular cataract surgery. The delayed emergence of exotropia with longer follow-up indicates
Anterior segment optical coherence tomography findings in the Infant Aphakia Treatment Study (IATS): a secondary analysis of a randomized clinical trial. To correlate the diagnosis of glaucoma among children in the Infant Aphakia Treatment Study (IATS) by age 10 years with anterior segment optical coherence tomography (AS-OCT) findings. A multicenter randomized controlled trial of 114 infants
Prospective analysis of Artisan aphakia intraocular lens implantation for nontraumatic ectopia lentis in children. To report long-term outcomes of iris claw aphakia intraocular lens (IOL) implantation for nontraumatic ectopia lentis (EL) in children. In this prospective study, children who underwent Artisan Aphakia IOL placement were included if they have a minimum of 1-year follow-up after implantation. Main outcome measures were: best-corrected distance visual acuity, reoperations, change in central corneal thickness (CCT), and corneal endothelial cell counts (ECC). The Artisan Aphakia IOL was implanted in a total of 76 eyes of 43 patients (68 eyes of 34 patients with EL). 56 eyes of 28 patients have been followed long enough to meet the inclusion criteria for this report. The average age
The contribution of intraocular lens calculation accuracy to the refractive error predicted at 10 years in the Infant Aphakia Treatment Study. To determine the relative contribution of intraocular lens (IOL) calculation accuracy and ocular growth variability to the long-term refractive error predicted following pediatric cataract surgery. Pseudophakic eyes of children enrolled in the Infant Aphakia Treatment Study (IATS) were included in this study. Initial absolute prediction error (APE) and 10-year APE were calculated using the initial biometry, IOL parameters, postoperative refractions, and mean rate of refractive growth. The cohort was divided into children with a low-initial APE (≤1.0 D) and a high-initial APE ( >1.0 D). The 10-year APE was compared between the two groups using
Refractive growth variability in the Infant Aphakia Treatment Study. Prediction of refraction after cataract surgery in children is limited by the variance in rate of refractive growth (RRG3). This study compared RRG3 in aphakic and pseudophakic eyes with their fellow, normal eyes in the Infant Aphakia Treatment Study. Twelve clinical sites in the United States. Randomized clinical trial