"Benactyzine"

. The selected drugs included "standard therapy" drugs (atropine and pralidoxime), reversible acetylcholinesterase inhibitors (huperzine A, galantamine, physostigmine and pyridostigmine), N-methyl-D-aspartate (NMDA) receptor antagonists (MK-801 and memantine), dual-function NMDA receptor and acetylcholine receptor antagonists (caramiphen and benactyzine) and anti-inflammatory drugs (dexamethasone and ibuprofen

Amitriptyline Amoxicillin Ampicillin Angiogenetic inhibitors [11] Arsenic Aspirin Atropine Auranofin Aurothioglucose Barbiturates Benactyzine Beta-blockers Beta carotene Bumetanide Amiodarone Amitriptyline Amoxicillin Ampicillin Angiogenetic inhibitors [11] Arsenic Aspirin Atropine Auranofin Aurothioglucose Barbiturates Benactyzine Beta-blockers Beta carotene

Amiodarone Amitriptyline Amoxicillin Ampicillin Angiogenetic inhibitors [11] Arsenic Aspirin Atropine Auranofin Aurothioglucose Barbiturates Benactyzine Beta-blockers Beta carotene

Amitriptyline Amoxicillin Ampicillin Angiogenetic inhibitors [11] Arsenic Aspirin Atropine Auranofin Aurothioglucose Barbiturates Benactyzine Beta-blockers Beta carotene Bumetanide Amiodarone Amitriptyline Amoxicillin Ampicillin Angiogenetic inhibitors [11] Arsenic Aspirin Atropine Auranofin Aurothioglucose Barbiturates Benactyzine Beta-blockers Beta carotene

Amiodarone Amitriptyline Amoxicillin Ampicillin Angiogenetic inhibitors [11] Arsenic Aspirin Atropine Auranofin Aurothioglucose Barbiturates Benactyzine Beta-blockers Beta carotene

kit, G117H and Phosphotriesterase isolated from soil bacterias, are now available for decontamination of NAs. Atropine and oximes are the well known antidotes that should be infused as clinically indicated. However, some new adjuvant and additional treatment such as magnesium sulfate, sodium bicarbonate, gacyclidine, benactyzine, tezampanel, hemoperfusion, antioxidants and bioscavengers have

A clinical trial of benactyzine hydrochloride (suavitil) as a physical relaxant.

Treatment of anxiety states. II. Clinical trial of benactyzine in anxiety states.

Effects of an anticholinergic drug, benactyzine hyrochloride, on vision and vision performance. Benactyzine is an anticholinergic agent which has been used in past years in psychiatry, but is little used today. It has central and peripheral anticholinergic effects, and when administered intramuscularly, it has a rapid onset of action. This may make it useful as an antidote for organophosphate that it reduced static and dynamic visual acuity, increased pupil size, reduced amplitude of accommodation and contrast sensitivity, while having little or no effect on glare recovery, color vision, intraocular pressure, stereoacuity, oculomotor tracking, and distance heterophoria. Benactyzine produced reductions in visual performance for up to 3 h and had the greatest effects on functions which have

Effects of benactyzine hydrochloride on dynamic vision functions. We have investigated the effects of an anticholinergic drug, benactyzine HCl on vision and vision function. Our experiments assess the time course and severity of benactyzine effects on visual acuity for static and moving targets, amplitude and dynamics of accommodation, pupil response to light and the spatial contrast sensitivity function. A single dose of the drug (4.14 mg/70 kg body weight, which is within the therapeutic range) and placebo were administered intramuscularly to 12 subjects. Large and significant decrements in visual function were demonstrated after the administration of benactyzine, particularly for those functions performed at near focus. The drug effect was rapid in onset, beginning 7-10 min after injection

Benactyzine in Psychoneurosis

and postganglionic action potentials. Block of conduction in the axon could be distinguished from block of the synaptic mechanism. The drugs did not appear to exert any one characteristic form of blocking action. A continuous spectrum of drug action linked an agent such as meprobamate which acted predominantly on the synapse to benactyzine which acted mainly by blocking axonal conduction. The drugs have been in terms of their axonal depressant action. Group III: chlorprothixene, promazine, N720 (dihydrochlorprothixene), chlorpromazine, hydroxyzine and benactyzine; these drugs also blocked axonal conduction but in addition they appeared to exert a "facilitating" action at the ganglionic synapse. The actions of adrenaline, adrenochrome, iproniazid, ergotoxine, mescaline and lysergic acid diethylamide

through the ganglion. The central depressant drugs tested were (in decreasing order of activity): amylobarbitone, pentobarbitone, carbromal, benactyzine, mephobarbitone, hydroxyzine, phenobarbitone, azacyclonol, methylpentynol carbamate, paraldehyde, phenytoin, mephenesin, chlorbutol, troxidone, methylpentynol and barbitone. All were weaker ganglion-blocking agents than tetraethylammonium. The intra -arterial injection of the central stimulant drugs leptazol, bemegride, amiphenazole and 5-(1,3-dimethylbut-2-enyl)-5-ethylbarbituric acid (McN 481) also depressed ganglionic transmission. Leptazol or bemegride did not antagonize the ganglion-blocking action of amylobarbitone or troxidone. The intra-arterial injection of pecazine and perphenazine, and the intravenous injection of barbitone, benactyzine

, methylpentynol carbamate and benactyzine were nonspecific, showing general depression of neuronal activity. Ganglion block with bretylium was nonselective in its site of depression of the postganglionic neurone in concentrations which only partly depressed the preganglionic nerve.

or significant increase in the latent period of pecking were taken as the criterion of effectiveness. Protection was afforded by caffeine, lysergic acid diethylamide, morphine, rauwolscine, triflupromazine and yohimbine. In addition, a significant increase in latent period was produced by artane, pentobarbitone, benactyzine, 2-bromolysergic acid diethylamide, cyclizine, diphenhydramine, ergotoxine, hyoscine

Benactyzine in Patients with Violent Tempers and Patients with Parkinsonism

Benactyzine as an Aid in Treatment of Anxiety States

Benactyzine in psychoneurosis; a controlled clinical trial in hospital patients.