Fusidic acid + betamethasonevalerate cream (Dermafusone) and infected atopic eczema Prescrire IN ENGLISH - Spotlight ''In the July-August issue of Prescrire International: fusidic acid + betamethasonevalerate cream (Dermafusone°) and infected atopic eczema'', 1 July 2021 {1}##LOC[OK]## {1} ##LOC[OK]## ##LOC[Cancel]## {1}##LOC[OK]####LOC[Cancel]## Register online| Log in| My Prescrire Issue * Prescrire events * A global network Offers * Subscribe now * Solidarity Subscription Rate * Subscribers: register online * Prescrire's other products * Free Special Edition * Sign up to receive the newsletter english.prescrire.org > Spotlight > 100 most recent > In the July-August issue of Prescrire International: fusidic acid + betamethasonevalerate cream (Dermafusone°) and infected atopic
308 nm-Excimer light together with topical betamethasonevalerate in treating alopecia areata. Excimer light was reported to be effective in treating alopecia areata (AA), as it induces T-cell apoptosis, however its combination with topical steroids in the management of AA still needs to be investigated. The study objectives were to determine the efficacy and safety of combining 308 nm-Excimer
Evaluation of fractional carbon dioxide laser alone versus its combination with betamethasonevalerate in treatment of alopecia areata, a clinical and dermoscopic study. Alopecia areata (AA) is a non-scarring tissue-specific autoimmune disorder. Many therapeutic modalities are available for the treatment of AA, but none has yet proven to be uniformly effective. Fractional carbon dioxide (FRCO ) laser has been introduced as a treatment modality for AA. The objective is to evaluate and compare the efficacy and safety of FRCO laser in treatment of AA alone or in combination with betamethasonevalerate cream. 30 patients were assigned to one of the following groups, Group A FRCO, Group B FRCO plus betamethasonevalerate cream or Group C (betamethasonevalerate cream). Patients received eight
Preventive effects of betamethasonevalerate ointment for radiation-induced severe oral mucositis in patients with oral or oropharyngeal cancer: protocol for a multicentre, phase II, randomised controlled trial (Bet-ROM study). This is a randomised, multi-centre, open-label, phase II study to evaluate the efficacy of betamethasonevalerate ointment on radiation-induced oral mucositis in patients with head and neck cancer undergoing concomitant radiotherapy with cisplatin or cetuximab. The trial will take place at seven hospitals in Japan. Patients will be randomised (1:1) into betamethasone and control groups after the occurrence of grade 1 oral mucositis. In the betamethasone group, patients will use betamethasonevalerate ointment five times a day, in addition to usual oral hygiene guidance
Topical BetamethasoneValerate As a Prophylactic Agent to Prevent Acute Radiation Dermatitis in Head and Neck Malignancies: A Randomized, Open-Label, Phase 3 Trial. We assessed the role of topical betamethasone as a prophylactic agent in patients receiving radiation for head and neck malignancies. This randomized, open-label, phase 3 trial was completed at a single research institute. Patients receiving curative radiation for head and neck cancer were randomized into 2 groups of 75 patients each by computer-generated permuted block random assignment. Patients in the test arm applied 0.1% topical betamethasonevalerate cream once a day, after radiation. Patients in the control arm received best supportive care. The Radiation Therapy Oncology Group acute toxicity grading scale was used to assess
A Comparison of BetamethasoneValerate 0.1% Cream Twice Daily Plus Oral Simvastatin Versus BetamethasoneValerate 0.1% Cream Alone in the Treatment of Vitiligo Patients Vitiligo, a common disorder of depigmentation, is often difficult to treat. Corticosteroids are known to be effective, but with modest results. Although simvastatin has been reported to be effective for immunorelated dermatologic disorders including vitiligo, controlled trials are lacking. This study was conducted to compare the efficacy of topical betamethasonevalerate 0.1% cream (as a standard method of treatment for vitiligo) versus a combination of betamethasonevalerate plus oral simvastatin in the treatment of vitiligo. Eighty-eight subjects with symmetric vitiligo who had body surface involvement up to 20% were divided
Role of betamethasonevalerate 2.250 mg medicated plaster in the treatment of psoriasis and other dermatological pathologies: a review Treating dermatological pathologies with topical corticosteroids under occlusion is often more effective than nonocclusive therapy, especially in the treatment of psoriasis. Betamethasonevalerate medicated plaster provides a controlled and localized method of dosing betamethasonevalerate, a well-established corticosteroid with vasoconstrictive, anti-inflammatory, immunosuppressive, and antiproliferative properties. This self-adhesive plaster is approved for the treatment of inflammatory skin disorders that do not respond to treatment with less potent corticosteroids. As a patch, it offers all the clinical benefits of occlusive therapy such as increased
Atorvastatin as adjunctive therapy for chronic plaque type psoriasis versus betamethasonevalerate alone: A randomized, double-blind, placebo-controlled trial. Psoriasis is a T helper 1 cell-mediated chronic inflammation. Statins have been found to have anti-inflammatory and immunomodulatory effects targeting T helper 1 cells and thus, are being investigated as treatments for psoriasis group: atorvastatin 40 mg OD; control group: placebo OD) and followed up for 6 months. All were allowed to use betamethasonevalerate 0.1% ointment twice a day for a maximum of 3 weeks continuous application with 1-week rest periods in between. Primary outcome measures were the mean percentage reduction in Psoriasis Area and Severity Index (PASI) scores and percentage of patients achieving PASI-50
Efficacy of Topical Latanoprost Versus Minoxidil and BetamethasoneValerate on The Treatment of Alopecia Areata. Alopecia areata (AA) is one of the most common causes of localized hair loss. There is no universally proven therapy that induces and sustains remission of hair growth in AA. To compare the efficacy and safety of topical latanoprost, minoxidil and betamethasonevalerate on hair growth in patients with AA. Hundred patients with AA classified into five groups of 20 treated with: Group I, latanoprost 0.1% lotion; Group II, minoxidil 5% lotion; Group III, betamethasonevalerate 0.1% solution; Group IV, combination of latanoprost lotion and betamethasonevalerate solution and Group V, a vehicle lotion control group. There was a statistically significant improvement in all therapeutic groups
Comparing the Effect of a Twice-Weekly Tacrolimus and BetamethasoneValerate Dose on the Subclinical Epidermal Barrier Defect in Atopic Dermatitis. The proactive use of topical anti-inflammatory (TAI) therapy to address subclinical inflammation is an effective, contemporary clinical strategy for the management of atopic dermatitis (AD). The interaction of a proactive TAI dose with the subclinical epidermal barrier defect in AD is yet to be determined. A randomised, observer-blind, functional mechanistic study in 17 subjects with quiescent AD was performed to compare the effect of a twice-weekly dose of betamethasonevalerate (0.1%) cream (BMVc), against tacrolimus (0.1%) ointment (TACo) on the biophysical and biological properties of the epidermal barrier. Application of BMVc preserved epidermal
Improvement of inflammatory dermatoses severity and quality of life in patients treated with a betamethasonevalerate plaster (LIBERE study). A ready to use betamethasonevalerate 0.1% (BMV) dressing was effective and well-tolerated by patients receiving chronic plaque psoriasis treatment. Collect data related to BMV dressing used in the context of market authorization. An observational
Betamethasonevalerate dressing is non-inferior to calcipotriol-betamethasone dipropionate ointment in the treatment of patients with mild-to-moderate chronic plaque psoriasis: results of a randomized assessor-blinded multicentre trial. A ready-to-use betamethasonevalerate 0.1% (BMV) dressing was found to be superior to placebo dressing and a reference 0.1% BMV cream in the treatment
The effect of tacrolimus compared to betamethasonevalerate on the skin barrier in volunteers with quiescent atopic dermatitis. Atopic dermatitis (AD) is an inflammatory skin disease arising as a result of immune system and skin barrier defects. Topical corticosteroids are safe and effective treatments for AD, when used in short courses. Prolonged use is associated with skin barrier damage . Topical calcineurin inhibitors are alternative immune-modulating treatments for AD purported to have no negative effects on the skin barrier. To compare the effects of betamethasonevalerate 0·1% cream (BMVc) and tacrolimus 0·1% ointment (TACo) on the skin barrier. Twenty volunteers with quiescent AD (no active signs for 6 months) participated in a randomized observer-blind study, wherein BMVc
Evaluation of Efficacy, Safety, and Tolerability of Fixed Dose Combination (FDC) of Halometasone 0.05% and Fusidic Acid 2% W/W Topical Cream Versus FDC of BetamethasoneValerate 0.12% and Neomycin Sulphate 0.5% W/W Topical Cream in the Treatment of Infect To evaluate the efficacy and safety of fixed drug combination (FDC) halometasone 0.05% and fusidic acid 2% (group A) vs FDC betamethasone 0.12
Kojic Acid vis-a-vis its Combinations with Hydroquinone and BetamethasoneValerate in Melasma: A Randomized, Single Blind, Comparative Study of Efficacy and Safety. Melasma is a relatively common, acquired symmetric hypermelanosis characterized by irregular light to gray-brown macules involving sun-exposed areas. Kojic acid, with its depigmenting potential due to tyrosinase inhibition and suppression of melanogenesis, has become a vital component of the dermatologists' armamentarium against melasma. To study and compare the efficacy of kojic acid 1% alone, vis-a-vis its separate combinations with 2% hydroquinone or 0.1% betamethasonevalerate and a combination of all these three agents with respect to the duration of symptoms and level of pigmentation in the therapy of melasma. Eighty
Is half strength of 0.05Â % betamethasonevalerate cream still effective in the treatment of phimosis in young children? 0.05 % betamethasonevalerate cream is generally used as an alternative to circumcision for the treatment of phimosis in boys. The aim of this study is to determine whether the half-strength formula (0.025 %) of betamethasone is as effective as 0.05 % betamethasone. All boys with phimosis seen at our institution between 2010 and 2012, whose parents complained that their children had problems of micturition, i.e., crying and ballooning, and sought for some instructions or treatments, were instructed to apply betamethasonevalerate cream. Two strengths, 0.05 and 0.025 %, were randomly applied to each patient twice a day for 2 months. The patients whose parents were not willing
no statistically significant differences in other quality of life, clinical-effectiveness or microbiological outcomes for the same comparison. There were no statistically significant differences in clinical outcome for topical gentamicin plus a topical corticosteroid (betamethasonevalerate) compared with a topical corticosteroid (betamethasonevalerate) alone in children with infected eczema. There were no statistically significant differences in microbiological outcomes for a topical antibiotic (fusidic acid or gentamicin) plus a topical corticosteroid (clobetasone butyrate, hydrocortisone or betamethasonevalerate) compared with a topical corticosteroid (clobetasone butyrate, hydrocortisone or betamethasonevalerate) alone in people (age not reported) with infected eczema. There were no differences in adverse
randomization, only 1 patient out of a total of 18 patients in the comparator arm (5.6%) actually received an alternative medication in addition to placebo, consisting of prednisolone, ciclosporin, methotrexate, betamethasone dipropionate and betamethasonevalerate. In contrast, the majority of patients in the comparator arm (94.4%) only received placebo during this period an alternative medication in addition to placebo, consisting of prednisolone, ciclosporin, methotrexate, betamethasone dipropionate and betamethasonevalerate. In contrast, the majority of patients in the comparator arm (94.4%) only received placebo during this period. Thus, the ACT for the treatment of flares specified by the G-BA has not been implemented in the comparator arm
classification (examples): Mild (hydrocortisone 1%), moderate (hydrocortisone valerate 0.2%), high (betamethasonevalerate 0.1%), very high (clobetasol dipropionate 0.05%).3Mild versus more potent steroids, marked improvement at 1-5 weeks:334% (mild) versus 52% (moderate) (4 RCTs, 449 patients), NNT=6.40% (mild) versus 71% (high) (9 RCTs, 458 patients), NNT=4.Moderate or high potency steroids versus more