Successful treatment of blepharitis with bibrocathol (Posiformin® 2 %). Bibrocathol is a well-established antiseptic drug for the treatment of acute eyelid diseases like blepharitis. Despite its frequent use in clinical practice, no controlled clinical trial on the efficacy of bibrocathol 2% eye ointment has been performed until now. The aim of the study was to investigate efficacy, safety and tolerability of bibrocathol (Posiformin® 2 %) eye ointment in patients diagnosed with blepharitis. In this multi-center, randomized, double-masked, placebo-controlled parallel-group comparison, the change of signs and symptoms (sum score) of blepharitis in 197 patients (ITT (intention-to-treat-group); mean age 56 ± 18 years, 56 % female, active drug:vehicle = 97:100) over 2 weeks treatment with bibrocathol 2
MEDLINE Link]. 75. Luchs J. Efficacy of topical azithromycin ophthalmic solution 1% in the treatment of posterior blepharitis. Adv Ther. 2008 Sep. 25(9):858-70. [QxMD MEDLINE Link]. 76. Bezdetko PA, Sergienko N, Dyomin Y, Korol A, Nikitin N, Merzbacher M, et al. Successful treatment of blepharitis with bibrocathol (Posiformin(®) 2 %). Graefes Arch Clin Exp Ophthalmol. 2012 Apr 25
MEDLINE Link]. 75. Luchs J. Efficacy of topical azithromycin ophthalmic solution 1% in the treatment of posterior blepharitis. Adv Ther. 2008 Sep. 25(9):858-70. [QxMD MEDLINE Link]. 76. Bezdetko PA, Sergienko N, Dyomin Y, Korol A, Nikitin N, Merzbacher M, et al. Successful treatment of blepharitis with bibrocathol (Posiformin(®) 2 %). Graefes Arch Clin Exp Ophthalmol. 2012 Apr 25
MEDLINE Link]. 75. Luchs J. Efficacy of topical azithromycin ophthalmic solution 1% in the treatment of posterior blepharitis. Adv Ther. 2008 Sep. 25(9):858-70. [QxMD MEDLINE Link]. 76. Bezdetko PA, Sergienko N, Dyomin Y, Korol A, Nikitin N, Merzbacher M, et al. Successful treatment of blepharitis with bibrocathol (Posiformin(®) 2 %). Graefes Arch Clin Exp Ophthalmol. 2012 Apr 25
MEDLINE Link]. 75. Luchs J. Efficacy of topical azithromycin ophthalmic solution 1% in the treatment of posterior blepharitis. Adv Ther. 2008 Sep. 25(9):858-70. [QxMD MEDLINE Link]. 76. Bezdetko PA, Sergienko N, Dyomin Y, Korol A, Nikitin N, Merzbacher M, et al. Successful treatment of blepharitis with bibrocathol (Posiformin(®) 2 %). Graefes Arch Clin Exp Ophthalmol. 2012 Apr 25
[Bibrocathol eye ointment is efficacious in blepharitis. Results from a randomized, double-blind, controlled clinical trial]. Bibrocathol (Noviform) 5% ointment is a frequently used therapy for blepharitis. The study included 197 patients who were randomized to be treated over 2 weeks with bibrocathol or an ointment vehicle, respectively. Slit lamp examinations were performed on day 1 (baseline ) and day 14 (end of study) to assess lid edema, lid erythema, debris, and pouting of Meibomian glands; patients rated their subjective complaints. Bibrocathol was superior to the control treatment in improving the sum score of the 5 scales (by 7.0 vs 4.7 points, p<0.001), especially in patients with primarily severe symptoms (by 8.3 vs 4.8, p<0.0001). Antiseptic therapy with bibrocathol eye ointment 3