BiliaryDyskinesia-Controversies, Diagnosis, and Management: A Review. Biliarydyskinesia is a disorder characterized by biliary pain, a sonographically normal gallbladder, and a reduced gallbladder ejection fraction on cholecystokinin-cholescintigraphy (CCK-HIDA) scan. Laparoscopic cholecystectomy remains a common treatment for biliarydyskinesia despite a lack of high-quality evidence supporting the practice. The following review summarizes the current biliarydyskinesia outcomes data, the diagnostic strategies and their limitations, biliarydyskinesia in the pediatric population, the emerging phenomenon of the hyperkinetic gallbladder, and suggestions for addressing identified knowledge gaps. The majority of studies on the topic are retrospective, with wide variations in inclusion
Variability in perioperative evaluation and resource utilization in pediatric patients with suspected biliarydyskinesia: A multi-institutional retrospective cohort study. Biliarydyskinesia (BD) is a common indication for pediatric cholecystectomy. While diagnosis is primarily based on diminished gallbladder ejection fraction (GB-EF), work-up and management in pediatrics is controversial. We
Efficacy, Safety, and Tolerability of 4-MUST Tablets in Chronic Cholecystitis and BiliaryDyskinesia A study of the efficacy, safety, and tolerability of the drug 4-MUST at various doses compared to placebo in patients with chronic cholecystitis and biliarydyskinesia
Trends of Cholecystectomies for Presumed BiliaryDyskinesia in Children in the United States. Biliarydyskinesia (BD) is a controversial clinical entity. Standardized diagnostic test and management guidelines are lacking in children. Published data suggest that long-term outcomes of surgical and medical management are similar. We sought to determine national population-based trends
Poor Reproducibility of Gallbladder Ejection Fraction by Biliary Scintigraphy for Diagnosis of BiliaryDyskinesia. Twenty percent of cholecystectomies in the US are performed for a diagnosis of biliarydyskinesia. Diagnosis is made by measuring gallbladder ejection fraction (GbEF) using hepatobiliary scintigraphy. Our purpose was to evaluate the reproducibility of GbEF measurements . This is a retrospective review of patients referred for cholecystectomy, from 2010 to 2016, with a diagnosis of biliarydyskinesia based on a GbEF test, who then underwent a repeat GbEF test. Thirty consecutive patients were identified by hospital records. Re-testing of GbEF was performed at least 6 weeks after the initial test using Tc-99m and slow injection of sincalide at 0.02 mcg/kg. On re-testing, 16 of 30
Decision-making patterns in managing children with suspected biliarydyskinesia To explore and to analyze the patterns in decision-making by pediatric gastroenterologists in managing a child with a suspected diagnosis of functional gallbladder disorder (FGBD). The questionnaire survey included a case history with right upper quadrant pain and was sent to pediatric gastroenterologists worldwide
Role of Cholecystectomy in Hyperkinetic BiliaryDyskinesia: A Systematic Review and Meta-Analysis PROSPERO International prospective register of systematic reviews Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied
Management of biliarydyskinesia in children Management of biliarydyskinesia in children Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility
Laparoscopic cholecystectomy for biliarydyskinesia in children: Frequency increasing. The treatment of children with biliarydyskinesia (BD) is controversial. As we recently observed an increasing frequency of referrals for BD in our institution the aim of the study was to re-evaluate the long-term outcome in children with BD. Children with laparoscopic cholecystectomy (LC) for suspected BD
Preoperative symptom duration predicts success in relieving abdominal pain caused by biliarydyskinesia in a pediatric population. The objective of this study was to identify factors associated with symptom relief in pediatric patients treated with laparoscopic cholecystectomy (LC) for biliarydyskinesia (BD). This was a case-control study of pediatric patients diagnosed with BD between January
gallbladder disease, partial biliary obstruction, and biliarydyskinesia as a cause of right upper quadrant pain. However, this test may be less useful in patients with atypical symptoms. Variant 4: Right upper quadrant pain. Fever, elevated WBC count. Suspected biliary disease. Negative or equivocal ultrasound. Next imaging study. CT Abdomen Although it has not been advocated as a primary imaging
The rising tide of cholecystectomy for biliarydyskinesia. Expert consensus defines biliarydyskinesia as a rare disorder of the gall-bladder characterised by pain and impaired gall-bladder function. To determine trends in cholecystectomy rates for biliarydyskinesia in the United States. As biliarydyskinesia does not have a distinct diagnosis code, the narrative diagnoses for patients were reviewed and abstracted for 200 patients treated for the most commonly used diagnosis codes for biliarydyskinesia (validation sample). Time trends in cholecystectomies and hospitalisations for biliary diseases were assessed using the Nationwide Inpatient Sample (Agency for Healthcare Research and Quality) based on codes for cholecystectomy and diagnosis codes for different biliary disorders
Normokinetic biliarydyskinesia: a novel diagnosis. Biliarydyskinesia diagnosed with CCK-HIDA scan and ejection fraction less than 35 % has been successfully treated by laparoscopic cholecystectomy. However, a population of patients with symptomatic biliary pain and a normal CCK-HIDA scan never receive a diagnosis, and thus no definitive treatment. Some of these patients report a reproducible pain during their CCK-HIDA scan. It is hypothesized that these patients have a novel diagnosis, normokinetic biliarydyskinesia, and may have resolution of pain when treated with cholecystectomy. A retrospective chart review was completed looking for patients with biliary pain in accordance with the ROME III criteria. Additional inclusion criteria were (1) greater than age 18 years, (2) reproducible
< 0.01). In both settings, the most common surgical indication was cholecystitis followed by biliarydyskinesia; nearly all procedures were performed laparoscopically (>99 %), and complications were rare with no deaths. Survey weight multivariate regression analysis showed patients cared for at rural hospitals had a higher odds ratio of routine discharge compared to those cared for at urban hospitals