Kurin Lock for bloodculture collection Kurin Lock for bloodculture collection Medtech innovation briefing Published: 31 May 2022 www.nice.org.uk/guidance/mib297 pathwaysSummary Summary • The technologytechnology described in this briefing is Kurin Lock. It is used for collecting blood samples for bloodculture. • The innovative aspectsinnovative aspects are that the technology diverts and isolates the first flash (about 0.15 ml) of blood, which may contain contaminants that can lead to a false-positive bloodculture result. • The intended place in therapyplace in therapy would be when samples for bloodculture are needed, as an alternative to standard collection methods. • The main points from the evidencemain points from the evidence summarised in this briefing are from 7 non-randomised
Summary - Judicious bloodculture use JULY 2024 Judicious bloodculture use English summary Une production de l’Institut national d’excellence en santé et en services sociaux (INESSS) 1 SUMMARY Judicious bloodculture use Introduction Bloodcultures are used to detect and identify microorganisms in the blood and to determine their susceptibility to anti-infectives. They play a major role among microbiological tests, since the presence of pathogenic agents in the blood has a direct impact on morbidity and the risk of death. Reportedly, in practice, most bloodcultures are negative, and those that are positive are sometimes contaminated. There are, therefore, various concerns, particularly with regard to the clinical context in which they are ordered and the blood sampling method used. The Direction de
Improving the bloodculture pathway – executive summary NHS England » Improving the bloodculture pathway – executive summary Skip to main content Cookies on the NHS England websiteWe’ve put some small files called cookies on your device to make our site work.We’d also like to use analytics cookies. These send information about how our site is used to a service called Google Analytics. We use are a member of the public looking for information and advice about coronavirus (COVID-19), including information about the COVID-19 vaccine, go to the NHS website. You can also find guidance and support on the GOV.UK website.Improving the bloodculture pathway – executive summaryDocument first published: 29 June 2022 Page updated: 29 June 2022 Topic: Sepsis Publication type: Guidance NHS England’s report
Clinical and economic evaluation of bloodculture whole process optimization in critically ill adult patients with positive bloodcultures. Optimizing bloodculture processing is important to ensure bloodstream infections are accurately diagnosed while minimizing adverse events caused by antibiotic abuse. We evaluated the impact of optimized bloodculture processes on antibiotic use, clinical outcomes and economics in intensive care unit (ICU) patients with positive bloodcultures. From March 2020 to October 2021, our microbiology laboratory implemented a series of improvement measures, including the clinical utility of Fastidious Antimicrobial Neutralization (FAN® PLUS) bottles for the BacT/Alert Virtuo bloodculture system, optimization of bottles reception, graded reports and an upgraded
Rapid implementation of bloodculture stewardship: institutional response to an acute national bloodculture bottle shortage. We describe our approach to addressing a nation-wide supply issue for bloodculture bottles. Aerobic bloodculture bottles received from our distributor July 1-15, 2024 was <1% of typical usage. Through education and ordering restrictions bloodculture designed to minimize
Effect of a bloodculture collection bundle on decreasing the contamination rate. In this study, we examined the effect of a bundled approach to blood collection for bloodculture on decreasing contamination. Commensal organisms were considered contaminants on the basis of the clinical course if they were recovered from only a single blood draw (set) and if a positive result for two sets was increased during the intervention. Both items were used in most patients requiring bloodcultures. Blood collection through a line caused contamination in only one case. The contamination rate decreased significantly from 2.0% to 1.0% after introduction of the bundle approach (3-year control period vs. 2-year bundle period, p<0.001), and a significant decrease in the contamination rate was observed
Clinical outcomes associated with blood-culture contamination are not affected by utilization of a rapid blood-culture identification system. Contaminated bloodcultures result in extended hospital stays and extended durations of antibiotic therapy. Rapid molecular-based bloodculture testing can speed positive culture detection and improve clinical outcomes, particularly when combined with an antimicrobial stewardship program. We investigated the impact of a multiplex polymerase chain reaction (PCR) FilmArray BloodCulture Identification (BCID) system on clinical outcomes associated with contaminated bloodcultures. We conducted a retrospective cohort study involving secondary data analysis at a single institution. In this before-and-after study, patients with contaminated bloodcultures
The Significance of FilmArray BloodCulture Identification Panel (FA-BCID) for Managing Patients with Positive BloodCultures. We analyzed the accuracy and time efficiency of the FilmArray bloodculture identification (FA-BCID) panel in identifying the pathogens in positive bloodcultures. Two-hundred and seventy-two individuals were randomly assigned as the control ( = 212) and FA-BCID ( = 60
Implementation of a diagnostic stewardship intervention to improve blood-culture utilization in 2 surgical ICUs: Time for a blood-culture change. We compared the number of blood-culture events before and after the introduction of a blood-culture algorithm and provider feedback. Secondary objectives were the comparison of blood-culture positivity and negative safety signals before and after the intervention. Prospective cohort design. Two surgical intensive care units (ICUs): general and trauma surgery and cardiothoracic surgery. Patients aged ≥18 years and admitted to the ICU at the time of the blood-culture event. We used an interrupted time series to compare rates of blood-culture events (ie, blood-culture events per 1,000 patient days) before and after the algorithm implementation with weekly
Investigating the time to bloodculture positivity: why does it take so long? Bloodstream infections (BSIs) are one of the most serious infections investigated by microbiologists. However, the time to detect a BSI fails to meet the rapidity required to inform clinical decisions in real time. Bloodculture (BC) is considered the gold standard for diagnosing bloodstream infections. However , the time to bloodculture positivity can be lengthy. Underpinning this is the reliance on bacteria replicating to a high concentration, which is necessary for the detection using routine bloodculture systems. To improve the diagnosis and management of patients with BSIs, more sensitive detection methods are required. The study aimed to answer key questions addressing the delay in BSI detection
Interrupted-time-series analysis of the impact of COVID-19 pandemic on bloodculture utilization in Shanghai. Limited information is available regarding the changes in bloodculture utilization following the COVID-19 pandemic. Bloodculture utilization rate is a critical indicator of diagnostic efficiency for infectious diseases. This study aims to describe the impact of the COVID-19 pandemic on bloodculture utilization rate in Shanghai. We conducted an interrupted time-series analysis based on electronic health records from the Shanghai Changzheng hospital from January 2014 to October 2023. The outcome measure was the rate of bloodculture utilization among inpatients with a temperature of ≥ 39.4 °C. The impact of the COVID-19 pandemic on bloodculture utilization was quantified by fitting
BloodCulture Use in Medical and Surgical Intensive Care Units and Wards. Bloodculture (BC) use benchmarks in US hospitals have not been defined. To characterize BC use in adult intensive care units (ICUs) and wards in US hospitals. A retrospective cross-sectional study of BC use in adult medical ICUs, medical-surgical ICUs, medical wards, and medical-surgical wards from acute care hospitals binomial regression models adjusted for unit type, hospital bed size, geographic region, seasonality, and state COVID-19 case load, with random intercepts accounting for clustering at unit and hospital levels. Secondary outcomes included bloodculture positivity, single BCs, BC contamination, and minimum threshold for BC use where bloodculture positivity would be optimized. A total of 362 327 blood
A randomised non-inferiority trial investigating antibiotic adjustments based on bloodculture in acute cholangitis. This study evaluated the adequacy of using bloodcultures alone for antibiotic therapy in mild-to-moderate acute cholangitis after adequate biliary drainage. A prospective, multi-centre, non-inferiority, randomised trial was conducted from August 2015 to September 2023 across 12 tertiary hospitals in South Korea. Patients were randomly assigned 1:1 to groups. The control group was administered antibiotics based on blood and bile culture results, whereas the experimental group treated based on bloodculture results alone. The primary outcome was the rate of organ failure, assessed by the presence of shock, acute kidney injury, altered mental status, and acute respiratory distress
Navigating the blood-brain barrier: enhancing bloodculture practices in the neuro-ICU. This study evaluates the implementation of a bloodculture (BCx) algorithm in the neurology ICU (NICU) to reduce BCx event (BCE) rates. Results show a reduction in BCE rates, without increasing adverse outcomes. The findings support the feasibility of BCx algorithms for improving diagnostic stewardship
Daily Surveillance BloodCultures in Children Supported With Extracorporeal Membrane Oxygenation: Single-Center, Retrospective Cohort Study, 2021-2023. Diagnosing bloodstream infections (BSIs) in patients on extracorporeal membrane oxygenation (ECMO) can be challenging due to circuit-controlled temperature, altered hemodynamics, and questionable reliability of inflammatory markers in critically ill patients. As a result, practice variability exists among ECMO centers regarding routine bloodcultures for surveillance of BSI. Our study aimed to evaluate daily surveillance bloodcultures in pediatric and neonatal ECMO patients. Retrospective review of daily surveillance bloodcultures from January 2021 to July 2023. We evaluated signs, symptoms, and laboratory results in patients
Single- versus multiple-sampling strategy for bloodcultures in the diagnosis of infective endocarditis: the prospective multicenter UniEndo study. Single-sampling strategy (SSS) for bloodcultures (BC) has not been evaluated in infective endocarditis (IE). We assessed the diagnostic performance of SSS vs conventional multi-sampling strategy (MSS) in IE diagnosis. Patients suspected of IE were
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from bloodcultures. Bloodculture (BC) remains the cornerstone for diagnosis of bloodstream infections (BSI), but the long turn-around time (TAT) hampers timely selection of appropriate chemotherapy. Novel molecular approaches have been developed to provide faster results
Epidemiology and Prognostic Factors Associated With Mold-Positive BloodCultures: 10-Year Data From a French Prospective Surveillance Program (2012-2022). While invasive fusariosis and lomentosporiosis are known to be associated with fungemia, overall data on mold-related fungemia are limited, hampering early management. This study aimed to describe the epidemiology of mold-positive bloodcultures. Epidemiological and clinical data on mold-positive bloodcultures from 2012 to 2022 were obtained from the RESSIF database. Pseudofungemia was excluded using modified Duthie and Denning criteria. Univariable and multivariable Firth logistical regression was used to study factors associated with 90-day mortality. Fusarium spp accounted for 67.5% of the 80 events, involving predominantly Fusarium
Weekend effect on bloodculture contamination: an observational study at a university hospital in Japan. An association between weekend/off-hour care and unfavorable clinical outcomes has been observed, commonly called the "weekend effect." In the present study, we examined whether there was a weekend effect associated with bloodculture (BC) contamination, which can lead to inappropriate