Camazepam versus placebo. A double-blind clinical study on geriatric patients suffering from psychic complaints. Short Communication. Camazepam, a dimethylcarbamic derivative of benzodiazepines, was studied on forty geriatric in-patients suffering from psychic disorders concerning anxiety and depression. Patients were treated with placebo and 30 mg of camazepam per day for 20 days using the double-blind method. The patients were assessed using a simplified rating scale with target symptoms of anxiety and depression. Statistical evaluation was performed with general Student's t-test for paired samples and chi2 test. Both groups of patients improved with camazepam and placebo. Camazepam 30 mg per day was more effective than placebo to a statistically significant degree.
Controlled double-blind trial of camazepam, a new benzodiazepine derivative, versus chlordiazepoxide. 31 in-patients with anxiety entered at random in a double-blind clinical trial of chlordiazepoxide and camazepam, a benzodiazepine derivative. They were assessed by three different rating scales. Statistical evaluation of the results showed similar psychopharmacological activity of both drugs . It is concluded that camazepam is suitable for treatment of mild and severe anxiety states.
Comparison between the central effects of camazepam and temazepam. Computerized analysis of sleep recordings. The effects of acute administration per os of 30 mg camazepam and the same dose of temazepam, were compared with placebo in 8 young male volunteers, fully adapted to the laboratory environment by 6 nights of adaptation. The study was double-blind, in a random order, 10 days separating found. Camazepam shows modification, with the same trend, but not reaching statistical significance. Concerning spectral analysis, temazepam induces a light increase of the relative power of the slowest frequencies, paralleled by an increase of the fast bands, while major effects are found on the characteristic periodicity of delta activities, which appear disrupted by the drug. These effects
Hypnotic activity and effects on performance of lormetazepam and camazepam--analogues of temazepam. 1 The effects of lormetazepam and camazepam on sleep electroencephalography, visuo-motor coordination, digit symbol substitution and subjective assessments of mood and sleep quality were compared with placebo in six young adult males (18-27 years). The study was double blind. 2 Over the dose range with the digit symbol test. 3 The hypnotic effect of 10-20 mg camazepam was limited to reduced awake activity (P less than 0.05), and with 20 mg there were increased substitutions on the digit symbol test. After 40 mg overnight stage 4 sleep was reduced (P less than 0.001) and performance at the digit symbol test was impaired (P less than 0.05 at 9.75 h). Morning ingestion of 20 mg camazepam did not alter
Reaction time to acoustic or visual stimuli after administration of camazepam and diazepam in man. 3-N,N-Dimethylcarbamoyloxy-7-chloro-5-phenyl-1-methyl-1,3-dihydro-2H-1,4-ben zodiazepin-2-one (Camazepam), a new anxiolytic benzodiazepine with weak muscle relaxant and hypnotic effect, was tested versus diazepam and placebo on reaction time to visual and acustic stimuli with a double-blind cross -over design carried out on 11 healthy volunteer human subjects. The response to acoustic stimuli was more rapid than that to visual stimuli with all the three treatments. The pattern of reaction times after camazepam was similar to that after placebo; diazepam retarded reaction times, with the maximum effect 1 h after the administration. A single dose of camazepam and diazepam considered active