Changes in cognitive function and daytime sleepiness in patients with chronic heart failure and Cheyne-Stokesrespiration with adaptive servo ventilation treatment. Cheyne - Stokesrespiration (CSR) is prevalent in patients with chronic heart failure (CHF). Adaptive Servo Ventilation (ASV) alleviates CSR and improves objective sleep quality. We investigated the effects of ASV on neurocognitive
Upright Cheyne-StokesRespiration in Patients With Heart Failure. Cheyne-Stokesrespiration (CSR) is believed to only occur in supine and sleeping conditions, and thus, CSR treatment is applied to those specific states. Although CSR has also been described in patients with heart failure (HF) during wakefulness, its persistence in an upright position is still unknown. The purpose of this study
Bioprofiles and mechanistic pathways associated with Cheyne-Stokesrespiration: insights from the SERVE-HF trial. The SERVE-HF trial included patients with heart failure and reduced ejection fraction (HFrEF) with sleep-disordered breathing, randomly assigned to treatment with Adaptive-Servo Ventilation (ASV) or control. The primary outcome was the first event of death from any cause, lifesaving cardiovascular intervention, or unplanned hospitalization for worsening heart failure. A subgroup analysis of the SERVE-HF trial suggested that patients with Cheyne-Stokesrespiration (CSR) < 20% (low CSR) experienced a beneficial effect from ASV, whereas in patients with CSR ≥ 20% ASV might have been harmful. Identifying the proteomic signatures and the underlying mechanistic pathways expressed in patients
Cheyne-Stokesrespiration related oscillations in cardiopulmonary hemodynamics in patients with heart failure. Although Cheyne-Stokesrespiration (CSR) is an oscillatory phenomenon, the direct effects of cyclical hyperventilation and apnea on cardiopulmonary hemodynamics have been poorly investigated. The aim of the study was to examine the echocardiographic changes associated with CSR phases
Association of serious adverse events with Cheyne-Stokesrespiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis. Increases in Cheyne-Stokesrespiration (CSR) cycle length (CL), lung-to-periphery circulation time (LPCT) and time to peak flow (TTPF) may reflect impaired cardiac function. This retrospective analysis used
ECG derived Cheyne-Stokesrespiration and periodic breathing are associated with cardiorespiratory arrest in intensive care unit patients. Cheyne-Stokesrespiration and periodic breathing (CSRPB) have not been studied sufficiently in the intensive care unit setting (ICU). To determine whether CSRPB is associated with adverse outcomes in ICU patients. The ICU group was divided into quartiles
Factors Associated with Cheyne-StokesRespiration in Acute Ischemic Stroke Cheyne-Stokesrespiration (CSR) is frequently observed in patients with acute stroke. There have been conflicting opinions about the associations of CSR with the location and size of the lesion. We aimed to better define the clinical relevance and pathogenesis of CSR in acute stroke. We investigated patients who had been
Distinct Patterns of Hyperpnea During Cheyne-StokesRespiration: Implication for Cardiac Function in Patients With Heart Failure In heart failure (HF), we observed two patterns of hyperpnea during Cheyne-Stokesrespiration with central sleep apnea (CSR-CSA): a positive pattern where end-expiratory lung volume remains at or above functional residual capacity, and a negative pattern where it falls
ECG-Derived Cheyne-StokesRespiration and Periodic Breathing in Healthy and Hospitalized Populations Cheyne-Stokesrespiration (CSR) has been investigated primarily in outpatients with heart failure. In this study we compare CSR and periodic breathing (PB) between healthy and cardiac groups. We compared CSR and PB, measured during 24 hr of continuous 12-lead electrocardiographic (ECG) Holter
Acute improvement of pulmonary hemodynamics does not alleviate Cheyne-Stokesrespiration in chronic heart failure-a randomized, controlled, double-blind, crossover trial. This randomized, controlled trial aimed to investigate whether acute improvement of pulmonary congestion would reduce the severity of Cheyne-Stokesrespiration (CSR) in patients with chronic heart failure (CHF). Twenty-one
Association between polymorphisms of the HSPB7 gene and Cheyne-Stokesrespiration with central sleep apnea in patients with dilated cardiomyopathy and congestive heart failure. CSR-CSA is frequent in patients with CHF. Dilated cardiomyopathy (DCM) is a structural heart disease with strong genetic background, yet one of the leading etiological causes of CHF. Studies have showed that the HSPB7
Quality of life improves in patients with chronic heart failure and Cheyne-Stokesrespiration treated with adaptive servo-ventilation in a nurse-led heart failure clinic. The aim of this study was to investigate if quality of life improved in chronic heart failure patients with Cheyne-Stokesrespiration treated with adaptive servo-ventilation in nurse-led heart failure clinic. Cheyne-Stokesrespiration is associated with decreased quality of life in patients with chronic heart failure. Adaptive servo-ventilation is introduced to treat this sleep-disordered breathing. Randomised, controlled design. Fifty-one patients (ranging from 53-84 years), New York Heart Association III-IV and/or left ventricular ejection fraction ≤40% and Cheyne-Stokesrespiration were randomised to an intervention group
Adaptive servo-ventilation therapy improves cardiac sympathetic nerve activity, cardiac function, exercise capacity, and symptom in patients with chronic heart failure and Cheyne-Stokesrespiration. Adaptive servo-ventilation (ASV) therapy has been reported to be effective for improving central sleep apnea (CSA) and chronic heart failure (CHF). The purpose of this study was to clarify whether ASV is effective for CSA, cardiac sympathetic nerve activity (CSNA), cardiac symptoms/function, and exercise capacity in CHF patients with CSA and Cheyne-Stokesrespiration (CSR-CSA). In this study, 31 CHF patients with CSR-CSA and a left ventricular ejection fraction (LVEF) ≤ 40% were randomized into an ASV group and a conservative therapy (non-ASV) group for 6 month. Nuclear imagings with I
Control theory prediction of resolved Cheyne-Stokesrespiration in heart failure. Cheyne-Stokesrespiration (CSR) foretells deleterious outcomes in patients with heart failure. Currently, the size of therapeutic intervention is not guided by the patient's underlying pathophysiology. In theory, the intervention needed to resolve CSR, as a control system instability (loop gain >1), can
Impact of Heart Transplantation on Cheyne-StokesRespiration in a Child Sleep disordered breathing is well described in adults with heart failure but not in pediatric population. We describe a 13-year-old Caucasian male with severe heart failure related to dilated cardiomyopathy who demonstrated polysomnographic features of Cheyne-Stokesrespiration, which completely resolved following cardiac transplantation. Cheyne-Stokesrespiration in children with advanced heart failure and its resolution after heart transplant can be observed similar to adults.
Cheyne-Stokesrespiration in heart failure: friend or foe? Hemodynamic effects of hyperventilation in heart failure patients and healthy volunteers. In patients with heart failure (HF), Cheyne-Stokesrespiration (CSR) is characterized by chronic hyperventilation (HV) with low arterial partial pressure of carbon dioxide (pCO2). It is still unclear whether this HV represents a compensatory
Anticyclic modulated ventilation versus continuous positive airway pressure in patients with coexisting obstructive sleep apnea and Cheyne-Stokesrespiration: a randomized crossover trial. Although coexisting obstructive sleep apnea (OSA) and Cheyne-Stokesrespiration (CSR) occur frequently in patients with heart diseases, optimal treatment remains unclear. Positive airway pressure (PAP