Decreasing Incidence of ConjunctivalSquamousCellCarcinoma in People with HIV in South Africa. The main risk factors for squamous cell carcinoma of the conjunctiva (SCCC) are immunodeficiency and exposure to ultraviolet radiation. Little is known about the SCCC epidemiology among people with HIV (PWH) in South Africa. We used data from the South African HIV Cancer Match study, a nation-wide
Incidence and epidemiology of conjunctivalsquamouscellcarcinoma in relation to the HIV epidemic in South Africa: a 25-year analysis of the National Cancer Registry (1994-2018). To describe the incidence and epidemiology of conjunctivalsquamouscellcarcinoma (CSCC) in South Africa over a 25-year period (1994-2018), with particular reference to the HIV epidemic. Incident cases
PD-L1/PD1 Expression, Composition of Tumor-Associated Immune Infiltrate, and HPV Status in ConjunctivalSquamousCellCarcinoma. Conjunctivalsquamouscellcarcinoma (SCC), a type of ocular surface neoplasia, is primarily treated by surgical resection and topical immuno- or chemotherapy. Metastatic disease may be treated with systemic chemo- or immunotherapy, albeit with variable response
Conjunctivalsquamouscellcarcinoma: prognostic factors for the recurrence and metastasis and clinicopathological characteristics at an oncological hospital in Peru. Conjunctivalsquamouscellcarcinoma (CSCC) is the most frequent malignant tumour of the conjunctiva, with scarce recurrence and infrequent metastasis. The purpose of this study is to describe the clinical and pathological
Ruthenium brachytherapy for intraocular growth of a conjunctivalsquamouscellcarcinoma: a case report The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctivalsquamouscellcarcinoma (SCC). In 2013, a 73-year-old man presented with a tumor blocking the angle and infiltrating corneal
Superficial radiotherapy as a treatment alternative for recurrent conjunctivalsquamouscellcarcinoma: a case study This case study discusses the use of superficial radiotherapy (SXRT) in the treatment of recurrent conjunctivalsquamouscellcarcinoma (SCC). Conjunctival SCC is often an aggressive cancer, with surgery the current standard of care. There is currently limited literature
Infiltrative Intraocular ConjunctivalSquamousCellCarcinoma after Local Resection and Brachytherapy: Clinical and Pathological Findings A pseudophakic 70-year-old man presented to the clinic with a slow-growing conjunctival mass in the left eye. He was diagnosed with a conjunctival exophytic lesion suspicious of invasive conjunctivalsquamouscellcarcinoma (CSCC). Excisional biopsy showed
ConjunctivalSquamousCellCarcinoma due to Long-term Placement of Ocular Prosthesis Conjunctivalsquamouscellcarcinoma (SCC) arising from an anophthalmic socket is quite rare, with few reports in the English literature. A 59-year-old man who had used an ocular prosthesis for 40 years had not removed the ocular prosthesis at all during the last 5 years. He had developed a mass on his entire
Establishment of a Cell Line From ConjunctivalSquamousCellCarcinoma: PeCa-UkHb-01. Until now, no epithelial cell line from conjunctivalsquamouscellcarcinoma (SCC), to our knowledge, has existed; therefore, the establishment of a model cell line would be a useful tool for further studies. In particular, the phenotypic and molecular characterization in comparison to other SCC cells
Plaque Radiotherapy in the Management of Scleral-Invasive ConjunctivalSquamousCellCarcinoma: An Analysis of 15 Eyes. Conjunctivalsquamouscellcarcinoma (SCC) is surgically managed with wide surgical excisional biopsy, superficial keratectomy, and cryotherapy. In eyes with residual tumor showing scleral invasion or intraocular involvement, enucleation is advised. To explore the role
Identification of Multiple DNA Copy Number Alterations Including Frequent 8p11.22 Amplification in ConjunctivalSquamousCellCarcinoma. Little is known about the molecular alterations that drive formation and growth of conjunctivalsquamouscellcarcinoma (cSCC). We therefore sought to identify genetic changes that could be used as diagnostic markers or therapeutic targets. The DNA extracted
Histologic and Genomic Analysis of Conjunctival SCC in African and American Cohorts Reveal UV Light and HPV Signatures and High Tumor Mutation Burden. Conjunctivalsquamouscellcarcinoma (conjSCC) is more prevalent and aggressive in sub-Saharan African countries compared with the rest of the world. This study aims to compare the genomic, immunophenotypic, and histologic features between
for indicators of immunosuppression within each population. We identified 38,047 cancer cases in SOTRs and 53,592 in PWH, yielding overall SIRs of 1.66 (95%CI = 1.65-1.68) and 1.49 (95%CI = 1.47-1.50), respectively. Forty-three cancer entities met selection criteria, including conjunctivalsquamouscellcarcinoma (SCC) (PWH SIR = 7.1, 95%CI = 5.5-9.2; SOTRs SIR = 9.4; 95%CI = 6.8-12.6). Sebaceous
Inflammatory induced astigmatism: acute changes in corneal curvature secondary to marginal keratitis and previous mitomycin-C treatment. A 52-year-old man presented with left eye redness, blurred vision, and photophobia. A history included marginal keratitis and conjunctivalsquamouscellcarcinoma treated with excision and topical mitomycin-C. Examination revealed current marginal keratitis
and Treatment of BehcetÆs Disease, April 2003 [As PDF].Finger PT; List of eye cancer conditions.Finger PT, Czechonska G, Liarikos S; Topical mitomycin C chemotherapy for conjunctival melanoma and PAM with atypia. BJO 1998 82: 476-479.Midena E, Angeli CD, Valenti M et al.; Treatment of conjunctivalsquamouscellcarcinoma with topical 5-fluorouracil. BJO 200084:268-272.RELATED INFORMATIONPhotodynamic
showed an infiltrative mass of the right orbit. Incisional biopsies confirmed conjunctivalsquamouscellcarcinoma of both sides (invasive in the right eye, in situ in the left eye). Exenteration was needed for control of invasive carcinoma in the right eye. Squamous cell carcinoma was treated without success in spite of surgical excision and aggressive treatment with multiple topical agents
with bulbar conjunctivalsquamouscellcarcinoma, 12 with bulbar conjunctival intraepithelial neoplasia. Major molecules of Hedgehog signaling pathway (Sonic Hedgehog [Shh] and Patched-1 [Ptch-1] and Glioma-associated oncogene [Gli-1]) were evaluated in paraffin-embedded tissue specimens using immunohistochemical staining. For each specimen, the percentage (<10%, 10-50%, >50%) and the intensity of the immunohistochemical staining (graded from 0 to 3) were calculated and the scores obtained by multiplication of two values were analyzed using the Kruskall-Wallis test. Shh and Ptch-1 expression levels were statistically significantly lower in the basal cell carcinoma group compared with the squamous cell carcinoma group (P=0.043 for Shh; P=0.030 for Ptch-1). In the conjunctivalsquamouscellcarcinoma group
of tumor being intraocular in 10 patients (35.7%,) and total orbital exenteration was the most commonly performed type of surgery in 16(57.1%) out of 27 patients. The most common etiology responsible for orbital exenteration, in pediatric age group of 9/27 patients (64.2%), was retinoblastoma whereas conjunctivalsquamouscellcarcinoma (SCC)accounts for 5 patients (38.4%) in adults. Overall, the most common cause of orbital exenteration was retinoblastoma 9(32.1%). The most common etiologies requiring orbital exenteration were retinoblastoma (in children and overall) and conjunctivalsquamouscellcarcinoma (in adults), both diseases that could be addressed with less invasive treatment modality if detected earlier in the disease process. Designing strategy is important for early detection