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. The development of mucocutaneous side-effects should not be considered as an absolute contraindication for the continuation of gold compound therapy. A low dose regimen may allow maintenance of therapeutic effect and improve tolerance in this group of patients. Gold salts, such as disodiumaurothiomalate (ATMO have been used in the treatment of rheumatoid arthritis (RA) for over 70 years. They suppress
Free thiomalate levels in patients with rheumatoid arthritis treated with disodiumaurothiomalate: relationship to clinical outcome of therapy. Sixteen patients with seropositive rheumatoid arthritis were treated with 20 mg disodiumaurothiomalate (Myocrisin) weekly for six months. Disease activity was assessed before and after treatment. Plasma profiles and urinary excretion of free thiomalate
Measurement of 'free' gold in patients receiving disodiumaurothiomalate and the association of high free to total gold levels with toxicity. Serum from patients with rheumatoid arthritis (RA) receiving disodiumaurothiomalate was analysed for total gold by atomic absorption spectrometry and for unbound (free) gold by the same method after ultrafiltration by an inert membrane. It was shown