"Drug allergy"

GLP-1 RA drug allergy GLP-1 RA drug allergy Cookie NoticeThis site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our cookies information for more details. OK skip to main content Toggle site navigation * Annual Meeting * Ask the Expert * Journals * Find An Allergist / Immunologist * Check Pollen Counts * Donate Search Members Portal Log * For Medical Students & Residents * Teaching Slides * Conditions & TreatmentsToggle sub-navigation * AllergiesToggle sub-navigation * Anaphylaxis * Drug Allergy * Eye (Ocular) Allergy * Food Allergy * Hay Fever / Rhinitis * Latex Allergy * Mold Allergy * Pet Allergy * Sinusitis * Skin Allergy * Stinging Insect Allergy * Allergy Articles * AsthmaToggle sub-navigation * Asthma Overview * Asthma Articles * EIB

Drug Allergy in Older Adults: A Study from the United States Drug Allergy Registry. Older adults have an increased risk of adverse drug reactions and negative effects associated with alternative antibiotic use. Although number of antibiotic allergies reported increases with age, the characteristics and outcomes of older adults receiving drug allergy assessment are unknown. To assess the characteristics and outcomes drug allergy evaluations in older adults. We considered patients aged ≥65y enrolled in the United States Drug Allergy Registry (USDAR), a US multi-site prospective cohort (01/16/2019-02/28/2022). Data were summarized using descriptive statistics. Of 1,678 USDAR participants from 5 sites, 406 older adults aged ≥65y (37% 65-69y, 37% 70-74y, 16% 75-79y, and 10% ≥80y) received 501 drug

The Drug Allergy History Tool (DAHT): Validation of a Patient-Reported Survey Instrument. While the reaction history is critical for drug allergy evaluations and is typically self-reported, there is no validated survey instrument to collect drug allergy history from patients. To validate a survey instrument that collects patient-reported drug allergy history. The Drug Allergy History Tool (DAHT ) was revised after three rounds of cognitive testing, with data assessed for reliability, through test-retest comparison, and quality and validity, through a concordance analysis against electronic health record (EHR) allergist documentation. Participants completing testing and surveys were recruited from drug allergy clinics at Massachusetts General Hospital. Primary evaluative measures were percent

Identifying the most at-risk age-group and longitudinal trends of drug allergy labeling amongst 7.3 million individuals in Hong Kong. Incorrect drug 'allergy' labels remain a global public health concern. Identifying regional trends of drug allergy labeling can guide appropriate public health interventions, but longitudinal or population drug allergy studies remain scarce. We analysed the serial epidemiology of drug allergy labeling to identify specific subgroups at highest risk of drug allergy labeling for potential interventions. Longitudinal, population-wide drug allergy labels and clinical data from over 7,337,778 individuals in Hong Kong between 2016 and 2021 were analysed. The absolute prevalence and incidence of documented drug allergy were 5.61% and 277/100,000 population, respectively

Drug Allergies in Older Adults: A Major Problem in a Specific Population. The use of medications in older adults is increasing due to the prevalence of chronic diseases. Data on the characteristics of drug allergies (DAs) in older adults are limited. This study investigated the prevalence and clinical characteristics of DAs in patients aged 65 years and older. Patient records were examined

Diagnosis and Clinical Management of Drug Allergies in Obstetrics and Gynecology: An Expert Review. Drug allergies, specifically antibiotic allergies, are frequently encountered in obstetrics and gynecology as10% of the United States population reports a penicillin allergy. This poses a particular challenge to the obstetrician-gynecologist as beta-lactam antibiotics are indicated as first-line testing and oral challenge. Skin testing for metronidazole allergy lacks sensitivity and specificity and thus oral challenge or desensitization procedure is the preferred approach for low risk and high-risk patients respectively. When it comes to drug allergies, and specifically antibiotic allergies, the role of the obstetrician-gynecologist is to identify patients with a reported allergy and to refer

Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy. Severe cutaneous adverse reactions (SCARs) mediated by cytotoxic T lymphocytes are a series of life-threatening conditions with a mortality of 4%-20%. The clinical application of tumor necrosis factor-alpha (TNF-α) antagonist improves the outcome of some SCARs patients; however, this is complicated

Impact of a drug allergy education course for non-specialists: Findings from ADAPT-A randomized crossover trial. The consequences of drug allergy remain a global health concern. Drug allergy is often a neglected topic and many non-specialists lack sufficient knowledge or confidence in evaluating or managing this common condition. Evidence-based interventions to better equip non-specialists to tackle drug allergy are needed. The aim of the study is to evaluate the effectiveness of an intensive educational course on drug allergy knowledge and practice of non-specialists. A randomized crossover trial (NCT06399601) was conducted among practicing physicians and nurses participating in an intensive drug allergy course-Advances in Drug Allergy & Penicillin Testing (ADAPT). Participants' baseline

collected from a food frequency questionnaire. After diagnostic work-up, 39 patients had confirmed drug allergy and 45 excluded, representing the study group and the control group, respectively. The majority (79%) were female, with mean age of 39.58±13.3 years. The 84 subjects revealed an anti-inflammatory diet pattern. No significative difference was found in DII scores between drug allergic patients Dietary parameters in patients with drug allergy: Assessing dietary inflammatory index. Research on the increasing incidence of allergic diseases evidenced the role of diet as a potential key factor. Diet can modulate the low-grade systemic inflammation related to obesity and several diseases. There are no published data on drug allergy. To investigate a potential association between diet

Skin testing as a biomarker in drug allergy. Despite the significant negative impact drug allergies can have on patient care, the diagnosis is largely based on clinical history, and there are limited diagnostic tests that can be done at the time of a reaction. Biomarkers are needed to improve the diagnosis and the identification of the culprit medication. Skin testing is the most useful biomarker

In vitro diagnostic testing for drug allergy in children. Diagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic-like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. In vivo tests are usually suggested as a first step; however, prick and intradermal tests could be painful

Placebo, Nocebo, and Patient-Reported Outcome Measures in Drug Allergy.

Analysis of the Safety of Drug Allergy Workups in a Spanish University Hospital: Drug Characteristics, Type of Reaction, and Patients' Age at the Initial Assessment. The drug provocation test (DPT) is the gold standard for the drug allergy workup; however, it is not free from severe adverse reactions. Our aim was to obtain robust data that predict a reaction during or after the DPT at the first contact with the patient in the allergy outpatient clinic. The population of this cross-sectional study comprised all patients undergoing a drug allergy workup (clinical assessment, specific IgE, or skin tests, or DPT) at University Hospital Fundacion Alcorcon in 2016. DPTs were performed until therapeutic doses were reached, and late reactions were checked. The clinical disorders assessed in our study

Changing patterns in the epidemiology of drug allergy. Drug allergy (DA) remains a complex and unaddressed problem worldwide that often deprives patients of optimal medication choices and places them at risk for life-threatening reactions. Underdiagnosis and overdiagnosis are common and due to the lack of standardized definitions and biomarkers. The true burden of DA is unknown, and recent

that are commonly seen with both historical drug reactions and during drug challenges, and it would suggest a low likelihood of a true drug allergic reaction. Grades 1 to 4 could meet the criteria for a positive challenge result and be considered indicative of a drug allergy. Grade 1 reactions are suggestive of a potential immediate drug reaction with mild symptoms. Grade 2 reactions are more likely US Drug Allergy Registry (USDAR) grading scale for immediate drug reactions. There is no accepted grading system classifying the severity of immediate reactions to drugs. The purpose of this article is to present a proposed grading system developed through the consensus of drug allergy experts from the US Drug Allergy Registry (USDAR) Consortium. The USDAR investigators sought to develop

Drug Allergy Alert System in a Spanish University Hospital: Description and Dynamics of Use. The drug allergy alert system reduces the frequency of adverse drug events, although it is subjected to collateral effects, since 80-90% of alerts are not real, and a large percentage of alerts are overridden (46.2-96.2%). We reviewed how the alert system is used at University Hospital Fundación Alcorcon (HUFA). Data were obtained from the drug allergy alert and the alert overriding notification forms (both in the period 2011-20). We also recorded drug allergy diagnoses at HUFA, drug consumption in primary care in 2016. We calculated the incidence of drug allergy alert activation, temporal trends in use, and correlations between the number of drugs in several datasets. We collected 15,535 alerts

Drug Allergy in Children: Adverse Reactions after Skin Testing. Skin tests are one of the most widely used diagnostic tools for suspected drug allergies in children. Studies on systemic reactions occurring during skin testing with allergens have mostly been conducted in pediatric and adult patient groups together. However, data on adverse reactions including allergic reactions after drug skin tests in children are scarce. It is aimed to determine the adverse reactions after skin test in children with suspected drug allergy. Patients who underwent a drug skin test due to the suspicion of drug allergy between May 2017 and June 2020 were evaluated, retrospectively. Data about adverse reactions seen after skin testing at the testing area in the clinic were analyzed. The study included 1,073

Female sex as a risk factor for penicillin drug allergy in the inpatient setting. Penicillin is the most common reported drug allergy. Previous literature suggests that there is increased prevalence of penicillin drug allergy in female patients in the outpatient setting. However, this is poorly described in the inpatient setting. This study was performed to determine whether female sex compared to males. Female sex may be a potential risk factor for objective penicillin drug allergy in the inpatient setting.

Drug Allergy Delabeling Programs: Recent Strategies and Targeted Populations. Drug allergy delabeling programs have become an essential element of antibiotic stewardship. Development of delabeling programs involves careful selection of target patient population, thoughtful design of delabeling approach, stakeholder engagement, assembly of key team members, implementation, and evaluation

Does Drug Allergy Workup in Children Satisfy Their Parents? Although drug allergy workup for pediatric patients (skin and drug provocation tests [DPT]) is performed, the procedures are troublesome, painful, and time-consuming. The aim of this study was to assess parents' perception of and satisfaction with their child's drug allergy workup. Further, to evaluate parents' tendency to use the tested drug following a negative DPT and the consequences of re-exposure. Parents of children that underwent drug allergy workup from January 2017 to August 2020 in the Pediatric Allergy Department of Trakya University Medical Faculty were included. Satisfaction levels were assessed via a telephone questionnaire (3 open-ended, 7 multiple-choice questions). Satisfaction was scored on a Likert scale (1