of skin disease (Pereira, Kremer et al. 2016). 4.1.9 Drug-induced chronic pruritus Drug-inducedpruritus without visible skin lesions accounts for approximately 5% of adverse cutaneous reactions. Almost any drug may induce pruritus by various pathomechanisms (Table 2) (Reich, Stander et al. 2009). Some may cause urticarial or morbilliform rashes presenting with acute pruritus. Furthermore, drug , e.g. biliary atresia or hypoplasia, familial hyperbilirubinemia syndromes, polycystic kidney disease or CKD (Weisshaar and Dalgard 2009, Wojtowicz-Prus, Kilis-Pstrusinska et al. 2016). Drug-inducedpruritus without any specific skin symptoms appears to be rare in children (Weisshaar and Dalgard 2009). Common medications associated with CP in adults play a minor role
* * Carcinoid syndrome * * Sipple syndrome (multiple endocrine neoplasia) * * Solid tumors, including GI malignancies, CNS tumors, and lung cancer * * Cutaneous T-cell lymphoma A variety of other systemic disorders are associated with pruritus, including the following: * * Drug-inducedpruritus without a rash * * Mastocytosis * * HIV infection and AIDS
* * Carcinoid syndrome * * Sipple syndrome (multiple endocrine neoplasia) * * Solid tumors, including GI malignancies, CNS tumors, and lung cancer * * Cutaneous T-cell lymphoma A variety of other systemic disorders are associated with pruritus, including the following: * * Drug-inducedpruritus without a rash * * Mastocytosis * * HIV infection and AIDS
the underlying diseases according to different categories: dermatological diseases, systemic diseases including diseases of pregnancy and drug-inducedpruritus, neurological and psychiatric diseases. In some patients more than one cause may account for pruritus (category "mixed") while in others no underlying disease can be identified (category "others"). This is the first version of a clinical classification
-inducedpruritus (none opioid-induced), 7 patients had paraneoplastic pruritus and 3 had cholestatic pruritus. After a run-in period, patients were randomly assigned to treatment with 20 mg paroxetine or placebo. The crossover took place after 7 days. Two patients discontinued treatment because of adverse effects of paroxetine. Twenty-four patients treated with paroxetine had lower pruritus intensity . Response was defined as at least 50% reduction of intensity of pruritus in the last three days of the treatment period vs. baseline. Adverse effects and patient satisfaction and preferences were also recorded. Twenty-six patients were included in the study; 17 of them had solid tumors, 4 had hematological malignancies and 5 had various nonmalignant or idiopathic conditions. Eight patients had drug
Drug-inducedPruritus: A Review. Pruritus is an unpleasant sensation that leads to scratching. In addition to several diseases, the administration of drugs may induce pruritus. It is estimated that pruritus accounts for approximately 5% of all skin adverse reactions after drug intake. However, to date there has been no systematic review of the natural course and possible underlying mechanisms of drug-inducedpruritus. For example, no clear distinction has been made between acute or chronic (lasting more than 6 weeks) forms of pruritus. This review presents a systematic categorization of the different forms of drug-inducedpruritus, with special emphasis on a therapeutic approach to this side-effect.
therapy may enroll. * Are on medications known to cause pruritus (ie, Erbitux®, opioids, cocaine, amphetamines, and angiotensin converting enzyme [ACE] inhibitors) and are suspected of having drug-inducedpruritus. * Have taken investigational medications within 30 days prior to Screening. * Are currently participating in any other clinical study. * Have a history (within the previous 4 weeks) of use