Preliminary results of the Multicenter Observational Study with Enoximone in Cardiac surgery (MOSEC). Perioperative administration of Enoximone has been shown to improve hemodynamics, organ function, and inflammatory response. Aim of the present study was to evaluate the effects of Enoximone after on-pump cardiac surgery. A protocol for a multicenter observational study was reviewed and approved by local ethic committee. This preliminary report involves the first 29 patients enrolled, in whom Enoximone was perioperatively administered in the context of on-pump cardiac surgery. All patients enrolled were propensity-matched 1:1 with controls not receiving Enoximone, renal function was evaluated in terms of estimated glomerular filtration rate (eGFR) with the CKD-EPI equation. After propensity
Oral Enoximone as an Alternative to Protracted Intravenous Medication in Severe Pediatric Myocardial Failure. Phosphodiesterase 3 inhibitors have been used successfully in pediatric patients with acute or chronic myocardial dysfunction over the last two decades. Their protracted continuous intravenous administration is associated with risk of infectious and thromboembolic complications. Weaning intravenous medication and starting oral angiotensin-converting enzyme (ACE) inhibitors and/or beta-blockers can be challenging. We reviewed retrospectively hospital records of 48 patients receiving oral enoximone treatment in a single tertiary pediatric cardiac center between November 2005 and April 2014. Failure to wean from intravenous milrinone infusion and/or intolerance of ACE inhibitors and/or beta
PDE3 inhibition with enoximone as firstâ€line therapy for severe persistent pulmonary hypertension of the newborn during neonatal transport: a case report Severe Persistent pulmonary hypertension of the newborn (PPHN) can be effectively treated with a PDE3 inhibitor as first-line treatment during neonatal transport when iNO is not readily available. Starting iNO as soon as possible is strongly
Perioperative administration of enoximone and renal function after cardiac surgery: a propensity-matched analysis. Perioperative administration of enoximone has been shown to improve hemodynamics, organ function, and inflammatory response. Aim of the present study is to evaluate the impact of enoximone on postoperative renal function after on-pump cardiac surgery. A total of 3727 patients undergoing cardiac surgery at one Institution between May 2004 and November 2010 were reviewed. A propensity score was built and a 1:1 perfect matching was performed, providing two fairly comparable cohorts of 712 patients each, receiving or not enoximone after surgery. Renal function was evaluated by lower glomerular filtration rate (GFR) value reached postoperatively. Overall 30-day mortality rate
The Effects of Enoximone in Acute Exacerbation COPD Introduction:The pharmacodynamic properties of enoximone could be beneficial for patients with an Acute Exacerbation COPD (AE-COPD). This research will focus on patients suffering of a severe AE-COPD and the bronchodilatory and inotropic effects of lower doses of enoximone. The main objective of the pilot study is to investigate if there is a bronchodilatory effect of enoximone in patients with AE-COPD. Secondary objective is to investigate a dose responsiveness in a range between 0.5 and 1.5 mg/kg enoximone.Methods:The study design is a prospective interventional non-randomized clinical series study involving patients admitted and intubated at the Intensive Care Unit (ICU) with an AE-COPD. Patients will receive three times a dose of 0.5 mg/kg
taking certain medicines stop, start or re-start smoking, monitoring and dose changes may be needed. Warfarin · 31 October 2023 How should medicines be dosed in children who are obese? Review on how to calculate medicine doses in children who are obese which includes a table on commonly prescribed medicines. Voriconazole · 28 May 2021 Eptifibatide Safety in Breastfeeding Enoximone Safety
(milrinone, enoximone) and α-adrenergic blockers (phenoxybenza-mine, phentolamine) are associated with both reduced Qp:Qs and increased Svo2. The risk of cardiac arrest or prearrest instability appears to be reduced by periop-erative strategies that include α-adrenergic blockade or phosphodiesterase inhibition. Although α-blockade is used in some centers for initial single-ventricle
functions. This organization is heavily perturbed during cardiac hypertrophy and heart failure (HF), which can contribute to disease progression. Clinically, PDE inhibition has been considered a promising approach to compensate for the catecholamine desensitization that accompanies HF. Although PDE3 inhibitors, such as milrinone or enoximone, have been used clinically to improve systolic function
by infusion of 0.5-3mg/kg/hr 3. Enoximone – only in europe: selective phosphodiesterase III inhibitor 4. Parenteral beta-agonists – evidence that inhaled beta agonists are superior to IV: exception is severe anaphylaxis requiring epinephrine (IM or IV) 5. High-dose inhaled glucocorticoids: opposing evidence for effect: net recommendation is PO intake in exacerbations 6. Helium-oxygen: heliox. The good ole
and optimal medical management including ionotropes. Randomized to receive either levosimendan or enoximone RCT 30 day mortality. Haemodynamic parameters 30-day survival greater in the levosimendan group 68.7% vs. 37.5% (p=0.023) Trend towards improved parameters of cardiac work e.g. cardiac index . Unblinded. Excluded those not requiring an IABP. Single centre. Small numbers. ? how often enoximone used in UK 2008
(see directly below).Provide symptom relief if needed - eg, opiate analgesia.Treat any electrolyte abnormalities.Treat any arrhythmias.Treat any underlying causes - eg, usual management of acute MI, urgent valve repair.Pharmacological inotropic supportVasopressor/inotropic medications used include dopamine, dobutamine, enoximone, and milrinone.Although inotropes increase cardiac output, they may also
of primary IABP implantation as compared to inotropes on haemodynamics in DHF-LO with no acute ischaemia. Patients (n=32) with DHF-LO despite IV diuretics were randomised to primary 50 mL IABP or inotropes (INO: enoximone or dobutamine). The primary endpoint was the improvement of organ perfusion assessed by ∆ mixed-venous oxygen saturation (SvO2) at 3 hours; secondary endpoints included ∆ cardiac power
A pathophysiological role of PDE3 in allergic airway inflammation Phosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in various cell types involved in allergic airway inflammation. Although PDE4 inhibition attenuates allergic airway inflammation, reported side effects preclude its application as an antiasthma drug in humans. Case reports showed that enoximone , eosinophilia, and reduced mucosal barrier function. Compared with wild-type (WT) littermates, mice with a targeted deletion of the PDE3A or PDE3B gene showed significantly reduced HDM-driven AAI. Therapeutic intervention in WT mice showed that all hallmarks of HDM-driven AAI were abrogated by the PDE3 inhibitors enoximone and milrinone. Importantly, we found that enoximone also reduced the upregulation
[15-132.5], P = .003; enoximone 177 hours [124.3-249.5] vs 48.5 hours [12-81 hours], P < .001, respectively). Critically ill patients with sclerosing cholangitis had longer intubation time (628.5 hours [377.3-883] vs 25 hours [9.8-117.5]; P < .001) and more surgical revisions (3 [2.5-6] vs 1 [0-2], P = .003) than the matching group. Bilirubin (23.3 mg/dL [14.4-32.9] vs 1 mg/dL [0.6-2.7]; P < .001
Right Ventricular Pressure Overload and Pathophysiology of Growing Porcine Biomodel. The primary objective was to create a clinically relevant model of right ventricular hypertension and to study right ventricular myocardial pathophysiology in growing organism. The secondary objective was to analyse the effect of oral enoximone (phosphodiesterase inhibitor) therapy on right ventricular ) and E (animals with PAB and oral administration of enoximone; n = 4). Direct pressure and echocardiographic measurements were taken during operation (time-1), and again at 40 days after surgery (time-2). The animals were killed, and tissue samples from the heart chambers were collected for quantitative morphological assessment. Statistical analysis was performed on all acquired data. At time-2
study.Strategy for data synthesiswe plan to synthesize the data from the studies included in this systematic review by performing a qualitative synthesis; we'll also conduct a thematic analysis of the findings from the individual studies to identify patterns and consistencies in the effects of dopamine, dobutamine, norepinephrine, epinephrine, enoximone and milrinone on cerebral oxygenation in TBI and SAH