A novel and practical asymmetric synthesis of eptazocine hydrobromide In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of -(-trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in excellent overall yield
or Dextropropoxyphene or dextrorphan or dezocine or diamorphine or diconal or dihydrocodeine or dihydroetorphine or Dihydromorphine or dimethylthiambutene or Diphenoxylate or dipipanone or enadoline or eptazocine or ethylketazocine or Ethylketocyclazocine or Ethylmorphine or etonitazene or Etorphine or etoxeridine or faxeladol or Fentanyl or furethidine or gelonida or Heroin or Hydrocodone or isalmadol
or Dihydromorphine or dimethylthiambutene or Diphenoxylate or dipipanone or enadoline or eptazocine or ethylketazocine or Ethylketocyclazocine or Ethylmorphine or etonitazene or Etorphine or etoxeridine or faxeladol or Fentanyl or furethidine or gelonida or Heroin or Hydrocodone or isalmadol or isomethadone or ketazocine or ketobemidone or ketogan or kyotorphin or lefetamine or levacetylmethadol or levomethadone
infiltration solution to the surgical area. Postoperative analgesia was obtained by continuous epidural administration of 90 mg eptazocine in normal saline for 48 hr. Supplemental analgesics were given on request. Postoperative pain control was assessed at rest and during coughing with a 10 cm VAS on the 1st, 2nd, and 3rd postoperative days (POD). The VAS scores at rest in Group L were lower than those
, during the baseline period, any morphine, oxycodone and fentanyl formulations other than the "regular opioid analgesic" being used at the time of giving written informed consent. * Use of codeine, dihydrocodeine, opium, pethidine, buprenorphine, pentazocine, tramadol, butorphanol, and eptazocine within seven days prior to randomization (except codeine at daily dosages up to 60 mg and dihydrocodeine