is provided as a service by IQWiG to English-language readers. However, solely the German original text is absolutely authoritative and legally binding. Extract IQWiG Reports – Commission No. A21-112 Relugolix/estradiol/nor-ethisterone acetate (uterine fibroids) – Benefit assessment according to §35a Social Code Book V1 Extract of dossier assessment A22-112 Version 1.1 Relugolix/estradiol/norethisterone
derivative of ethisterone, is a steroid molecule with significant androgen activity and is effective in the treatment of adenomyosis and endometriosis. Its use is associated with androgenic side effects. Vaginal symptoms may benefit from a vaginal moisturizer, such as Replens, and/or low-dose vaginal estrogen, such as Vagifem or Femring. Although these have not been studied in adenomyosis, the lack
the characterization of a multivalent conjugate presenting two bioactive ethisterone ligands arrayed as spatially defined pendant groups on a peptoid oligomer. The conjugate, named Multivalent Peptoid Conjugate 6 (MPC6), suppressed the proliferation of multiple AR-expressing prostate cancer cell lines including those that failed to respond to enzalutamide and ARN509. The structure-activity relationships of MPC6 variants were evaluated, revealing that increased spacing between ethisterone moieties and changes in peptoid topology eliminated its antiproliferative effect, suggesting that both ethisterone ligand presentation and scaffold characteristics contribute to MPC6 activity. Mechanistically, MPC6 blocked AR coactivator-peptide interaction and prevented AR intermolecular interactions. Protease sensitivity
derivative of ethisterone, is a steroid molecule with significant androgen activity and is effective in the treatment of adenomyosis and endometriosis. Its use is associated with androgenic side effects. Vaginal symptoms may benefit from a vaginal moisturizer, such as Replens, and/or low-dose vaginal estrogen, such as Vagifem or Femring. Although these have not been studied in adenomyosis, the lack
derivative of ethisterone, is a steroid molecule with significant androgen activity and is effective in the treatment of adenomyosis and endometriosis. Its use is associated with androgenic side effects. Vaginal symptoms may benefit from a vaginal moisturizer, such as Replens, and/or low-dose vaginal estrogen, such as Vagifem or Femring. Although these have not been studied in adenomyosis, the lack
the oral contraceptive pill. They include: * mifepristone * dydrogesterone * medroxyprogesterone acetate * norethisterone * ethisterone * norgestrelLast reviewed 01/2018Links: * types * physiology * therapeuticsClinical specialties cardiovascular medicine dermatology diabetes and endocrinology ear, nose and throat evidence-based medicine gastroenterology general information general practice
patients treated with gestrinone at 1 week. Experiments in vitro suggest that this was largely due to ethisterone (a major metabolite of danazol) competing with testosterone for SHBG binding sites. After 4 weeks on treatment there was a similar, near maximal reduction in SHBG binding of testosterone in both treatment groups. At the low levels of SHBG binding capacity reached by this time the extra effect
Randomised trial of high doses of stilboestrol and ethisterone in pregnancy: long-term follow-up of mothers. In 1950 a trial was set up to evaluate the effects of large doses of stilboestrol and ethisterone on rates of fetal loss in pregnant diabetic women. Eighty women were allocated at random to receive the hormonal treatment and 76 to receive inactive tablets of identical appearance. At follow
Randomised trial of high doses of stilboestrol and ethisterone therapy in pregnancy: long-term follow-up of the children. The 27-year follow-up is reported of 136 children whose mothers were involved in a randomised trial of high doses of stilboestrol and ethisterone therapy during pregnancy. The children were not contacted directly. Information about them was obtained from hospitals, general , p less than 0.02). These findings suggest that some interference with sexual function may not be uncommon in males exposed to high doses of stilboestrol and ethisterone while in utero.
acetate (MPA) 10 mg p.o. 12 days/month, transdermic nor-ethisterone acetate (NETA) 0.25 mg integrated in the ethinil-estradiol patches for the last two weeks of each cycle, micronized progesterone (MP) 100 mg transvaginally 12 days/month. None of the tested protocols significantly altered the lipidic profile of this group of patients. We noticed different effects on the estrogen stimulated endometrium
varies with the drug and dosage.[1]Androgens[edit]The only sex steroid currently utilized in women that can cause virilization of female fetuses when administered in usually administered doses is the androgen danazol, a derivative of ethisterone (ethinyltestosterone).[1]Fetal masculinization of female external genitalia has resulted from doses of danazol as low as 200 mg/day, whereas 800 mg/day is the usual initial dose when danazol is used to treat severe endometriosis.[1]Progestogens[edit]In general, pregnane derivatives (e.g., progesterone, dydrogesterone, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate) do not virilize even in high dose; testosterone derivatives (ethisterone) and 19-nortestosterone (norethisterone, norethisterone acetate, etc.) generally virilize
Oral contraceptive, pulmonary artery thrombosis and anti-ethinyl-oestradiol monoclonal IgG. Pulmonary artery thrombosis and an anti-ethinyl-oestradiol monoclonal IgGlambda were found to be associated in a 36-year-old woman (Mrs MAI.) who took an oral contraceptive containing 50 mug ethinyl-oestradiol and 500 mug nor-ethisterone daily. After appropriate purification including methods by which
Possible Clinical Implications of Therapeutically Induced Temperature Changes in Continuously Monitored Tumour mass: (Preliminary Report) Continuous temperature monitoring was carried out with thermistor probes implanted in breast tumours and in normal breast tissue. The results indicate that an initial rise in tumour temperature induced by the administration of nor-ethisterone acetate