MRI of a recurrent adenoid cystic carcinoma of the trachea, treated with fastneutrontherapy Adenoid cystic carcinoma (ACC) of the trachea is a rare tumour, which responds well to high linear energy transfer radiation, such as neutron therapy. Both CT and MRI are useful for its diagnosis, with MRI being superior at determining the extent of disease and perineural involvement. Identification imaging can be useful in the distinction between the two. We present a case of tracheal ACC treated with fastneutrontherapy and followed with MRI.
Paving the Road for Modern Particle Therapy – What Can We Learn from the Experience Gained with FastNeutronTherapy in Munich? While neutron therapy was a highly topical subject in the 70s and 80s, today there are only a few remaining facilities offering fastneutrontherapy (FNT). Nevertheless, up to today more than 30,000 patients were treated with neutron therapy. For some indications
an organ-at-risk (OAR) avoidance approach. A number of beam orientation schemes were investigated in an attempt to approach an optimum solution. The IMNRT plans were created retrospectively for 5 patients previously treated for prostate adenocarcinoma using fastneutrontherapy (FNT), and a comparison of these plans is presented. Dose distributions and dose-volume histograms (DVHs) were analyzed
Incidence of sarcoma in patients treated with fast neutrons. The aim of this study is to report the incidence of soft tissue sarcoma in a large group of patients treated with fast neutrons. A systematic review was conducted of long-term follow-up after trials of fastneutrontherapy for cancers at various sites. The study took place at Edinburgh Cancer Centre, Western General Hospital, Edinburgh
Fastneutrontherapy for squamous cell carcinoma in the head and neck region: results of a randomized trial. A randomized trial of fast neuron therapy compared with 4MV photons for patients with head and neck cancer is reported. One hundred and sixty-eight patients were recruited between 1977 and 1984. The minimum follow-up is 2 years. Three patients were withdrawn before treatment began. Eighty
-based cyclotrons with gantry-mounted beam-delivery systems has recently been activated to evaluate more rigorously the role of fast-neutrontherapy for advanced cervical cancer.
Fast-neutrontherapy in advanced head and neck cancer: a collaborative international randomized trial. To compare the efficacy of fast-neutron radiotherapy with that of conventionally fractionated photon therapy in the management of patients with locally advanced squamous cell carcinoma of the head and neck. Patients with Stage III or IV disease were randomized to receive either 20.4 Gy/12 and survival were not improved, and the incidence of late normal tissue toxicity was increased. As a result, fast-neutrontherapy for advanced squamous cell carcinoma of the head and neck can only be recommended for patients in whom the logistic benefit of treatment in 12 sessions over 4 weeks outweighs the increased risk of late toxicity.
Fastneutrontherapy of bronchus carcinoma: the pooled results from two European centres. The Berlin-Buch and Heidelberg centres used fastneutrontherapy in bronchial carcinomas. The neutron source was a cyclotron in Berlin-Buch/Rossendorf and a d-t generator in Heidelberg. Three hundred twelve patients with inoperable bronchial carcinoma were treated with fastneutrontherapy alone
The treatment of recurrence following fastneutrontherapy for head and neck malignancy. Twenty-eight patients received fastneutrontherapy for head and neck malignancy. Of these, seven had no recurrence, 13 had a recurrence at the primary site, five had a recurrence in the neck and three had a recurrence in the neck and at the primary site. Treatment of a primary site recurrence was difficult with seven of the eight patients submitted for major surgical resection developing serious complications. Of the six patients developing a fistula four required flap repair. The tumour specific 5-year survival for the whole group of 28 patients was 29%. The surgical treatment of locoregional recurrence following fastneutrontherapy is fraught with problems and some type of flap repair is usually necessary.
Fastneutrontherapy at the end of 1988--a survey of the clinical data. The clinical results reported from the different neutron therapy centres, in USA, Europe and Asia, are reviewed. Fast neutrons were proven to be superior to photons for locally extended inoperable salivary gland tumours. The reported overall local control rates are 67% and 24% respectively. Paranasal sinuses and some tumours
in survival was observed in the subset of patients with squamous cell histology. The NTCWG trial comparing fast-neutrontherapy versus conventional photon irradiation in the treatment of advanced squamous cell carcinomas of the head and neck showed a statistically significant improvement in initial complete response (70 vs 52%) favoring neutrons. However, subsequent failures erased any difference
Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease Purpose. To present a case study involving the use of fastneutrontherapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla.Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chemotherapy
62 patients who had been referred for fastneutrontherapy because it was thought that no other treatment would be effective experienced complete regression of the tumours, and only two recurred. Tumours of the buccal cavity and salivary glands responded particularly well and the relief of pain and ulceration was striking. Side effects were not serious and did not differ from those seen