Determining the optimal route of faecalmicrobiota transplant in patients with ulcerative colitis: the STOP-Colitis pilot RCT Determining the optimal route of faecalmicrobiota transplant in patients with ulcerative colitis: the STOP-Colitis pilot RCT * Text only * * Home * Journals * * Other NIHR research * * For authors * For reviewers * About * Policies * * Accessibility * Journals LibraryNHS
Effect of rabbit gastrointestinal stasis (RGIS) on the fecalmicrobiota of pet rabbits (Oryctolagus cuniculus). Rabbit (Oryctolagus cuniculus) gastrointestinal stasis syndrome (RGIS) is defined as reduced motility of any part of the digestive tract that can lead to impaction and death if left untreated. This study aimed to describe the effect of RGIS on the fecalmicrobiota of client-owned pet dominated the eukaryotic microbiota in all rabbits. RGIS is one of the most common issues in clinical practice. This study is the first to perform detailed characterization of the effects of RGIS on the domestic rabbit's bacterial and eukaryotic fecalmicrobiota. The results demonstrate a significant change in the relative abundance of seven bacterial genera associated with RGIS. Future research
FecalMicrobiota Therapy in Canada: Barriers and Facilitators to Access FecalMicrobiota Therapy in Canada: Barriers and Facilitators to Access | CADTH Skip to main content * About * Collaboration/Outreach * Patient/Community * Careers * Contact * My CADTH * FR * Reports * Reports * Reimbursement Review * Health Technology Review * Reference List * Horizon Scan Request Form * Who and What is Eligible * News & Events * News * Symposium * CADTH in Conversation with... * Events * Email: requests@cadth.ca * About * Collaboration/Outreach * Patient/Community * Careers * Contact * My CADTH Breadcrumb 1. Home 2. FecalMicrobiota Therapy in Canada: Barriers and Facilitators to Access Copied to clipboard Fecal
Clinical Practice Guidelines for FecalMicrobiota Transplantation in Korea Fecalmicrobiota transplantation (FMT) is a highly efficacious and safe modality for the treatment of recurrent or refractory infection (CDI), with overall success rates of 90%. Thus, FMT has been widely used for 10 years. The incidence and clinical characteristics of CDI, the main indication for FMT, differ between
Impact of fecal sample preservation and handling techniques on the canine fecalmicrobiota profile. Canine fecalmicrobiota profiling provides insight into host health and disease. Standardization of methods for fecal sample storage for microbiomics is currently inconclusive, however. This study investigated the effects of homogenization, the preservative RNAlater, room temperature exposure duration, and short-term storage in the fridge prior to freezing on the canine fecalmicrobiota profile. Within 15 minutes after voiding, samples were left non-homogenized or homogenized and aliquoted, then kept at room temperature (20-22°C) for 0.5, 4, 8, or 24 hours. Homogenized aliquots then had RNAlater added or not. Following room temperature exposure, all aliquots were stored in the fridge (4°C
FecalMicrobiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An Open-Label, Randomized, Nonplacebo-Controlled Study Fibromyalgia (FM) is a complex and poorly understood disorder characterized by chronic and widespread musculoskeletal pain, of which the etiology remains unknown. Now, the disorder of the gut microbiome is considered as one of the main causes of FM. This study aimed to investigate the potential benefits of fecalmicrobiota transplantation (FMT) in patients with FM. A total of 45 patients completed this open-label, randomized, nonplacebo-controlled clinical study. The numerical rating scale scores in the FMT group were slightly lower than the control group at 1 month (P > .05), and they decreased significantly at 2, 3, 6, and 12 months after treatment (P < .001). Besides
Outcomes after FecalMicrobiota Transplantation in combination with Bezlotoxumab for Inflammatory Bowel Disease and Recurrent C. difficile Infection Fecalmicrobiota transplantation (FMT) prevents recurrent C. difficile infections (rCDI) in IBD. Patients. Bezlotoxumab is also indicated to prevent rCDI. We assess the impact of FMT in combination with bezlotoxumab in patients with IBD and rCDI. We
AGA Clinical Practice Guideline on FecalMicrobiota-Based Therapies for Select Gastrointestinal Diseases Fecalmicrobiota-based therapies include conventional fecalmicrobiota transplant and US Food and Drug Administration-approved therapies, fecalmicrobiota live-jslm and fecalmicrobiota spores live-brpk. The American Gastroenterological Association (AGA) developed this guideline to provide recommendations on the use of fecalmicrobiota-based therapies in adults with recurrent Clostridioides difficile infection; severe to fulminant C difficile infection; inflammatory bowel diseases, including pouchitis; and irritable bowel syndrome. The guideline was developed using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework to prioritize clinical questions, identify
FecalMicrobiota Therapy in Canada: An Environmental Scan FecalMicrobiota Therapy in Canada: An Environmental Scan | CADTH Skip to main content * About * Collaboration/Outreach * Patient/Community * Careers * Contact * My CADTH * FR * Reports * Reports * Reimbursement Review * Health Technology Review * Reference List * Horizon Scan * Resources Request Form * Who and What is Eligible * News & Events * News * Symposium * CADTH in Conversation with... * Events * Email: requests@cadth.ca * About * Collaboration/Outreach * Patient/Community * Careers * Contact * My CADTH Breadcrumb 1. Home 2. FecalMicrobiota Therapy in Canada: An Environmental Scan 3. Reports 4. Health Technology Review
The use of faecalmicrobiota transplant as treatment for recurrent or refractory Clostridioides difficile infection and other potential indications: second edition of joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) The first British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS)-endorsed faecalmicrobiota transplant (FMT
Fecalmicrobiota profiles of growing pigs and their relation to growth performance. The early gut microbiota composition is fundamentally important for piglet health, affecting long-term microbiome development and immunity. In this study, the gut microbiota of postparturient dams was compared with that of their offspring in three Finnish pig farms at three growth phases. The differences in fecal diminished, shifting towards the microbiome of the dam. In conclusion, the fecalmicrobiota of pigs tends to develop towards a similar alpha and beta diversity despite development group and rearing environment.
FecalMicrobiota Transplantation for Treatment of Parkinson Disease: A Randomized Clinical Trial Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecalmicrobiota transplantation (FMT) has shown promising effects in preclinical PD models. To assess the safety and symptomatic efficacy of colonic single-dose anaerobically prepared FMT. This was a double-blind, placebo -controlled, randomized clinical trial conducted between November 2020 and June 2023 with a follow-up period of 12 months at 4 hospitals in Finland. Patients with PD aged 35 to 75 years in Hoehn & Yahr stage 1-3 with a mild to moderate symptom burden and dysbiosis of fecalmicrobiota were included. Of 229 patients screened, 48 were randomized and 47 received the intervention. One patient discontinued due
Fecalmicrobiota transplantation from protozoa-exposed donors downregulates immune response in a germ-free mouse model, its role in immune response and physiology of the intestine. Intestinal parasites are part of the intestinal ecosystem and have been shown to establish close interactions with the intestinal microbiota. However, little is known about the influence of intestinal protozoa on the regulation of the immune response. In this study, we analyzed the regulation of the immune response of germ-free mice transplanted with fecalmicrobiota (FMT) from individuals with multiple parasitic protozoans (P) and non-parasitized individuals (NP). We determined the production of intestinal cytokines, the lymphocyte populations in both the colon and the spleen, and the genetic expression of markers
Allogenic faecalmicrobiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial (phase II). Exposure of critically ill patients to antibiotics lead to intestinal dysbiosis, which often manifests as antibiotic-associated diarrhoea. Faecalmicrobiota transplantation restores gut microbiota and may group will receive standard treatment based on oral diosmectite. In the intervention group, patients will receive, in addition to the standard of care, faecalmicrobiota transplantation via rectal tube, in the form of a preparation mixed from 7 thawed aliquots (50 mL) made from fresh stool of 7 healthy unrelated donors and quarantined deep frozen for 3 to 12 months. Primary outcome is treatment
Effects of Retrograde Colonic Enema-Based FecalMicrobiota Transplantation in the Treatment of Childhood Constipation: A Randomized, Double-Blind, Controlled Trial Management of intractable childhood constipation is still challenging. The efficacy of retrograde colonic enema (RCE) with fecalmicrobiota transplantation (FMT) in intractable childhood constipation has not been established although
The fecalmicrobiota of the mouse-eared bat (Myotis velifer) with new records of microbial taxa for bats. Studies on the fecal microbiome of wild animals reveal valuable information on the feeding habits of the host and the possible roles of bacteria in digestion. In this work we characterized the fecalmicrobiota of seven male and seven female Myotis velifer bats using the V3-V4 regions richness than those from females. This study revealed that the fecalmicrobiota of M. velifer had a unique and more diverse composition compared to the microbiota reported for other bats. We identified 24 families and two abundant genera Cetobacterium and Haematospirillum in both males and females. Cetobacterium may produce vitamin B12 that is not produced by animals and Haematospirillum, which has been
Fecalmicrobiota transplantation for vancomycin-resistant Clostridium innocuum infection in inflammatory bowel disease: A pilot study evaluating safety and clinical and microbiota outcome. Clostridium innocuum is a vancomycin-resistant pathobiome associated with poor clinical outcomes in inflammatory bowel disease (IBD). In ulcerative colitis (UC), it correlates with reduced remission rates , while in Crohn's disease (CD), it is linked to creeping fat formation and intestinal strictures. Notably, some patients experience refractory or recurrent C. innocuemailum infections despite metronidazole treatment. This study evaluates the safety and efficacy of single-dose fecalmicrobiota transplantation (FMT) in IBD patients with refractory or recurrent C. innocuum infections. We conducted