"Fibroepithelial neoplasm"

An integrative approach for exploring the nature of fibroepithelial neoplasms. Malignant phyllodes tumour (MPT) is a rare breast malignancy with epithelial and mesenchymal features. Currently, there are no appropriate research models or effective targeted therapeutic approaches for MPT. We collected fresh frozen tissues from nine patients with MPT and performed whole-exome and RNA sequencing , and suggested that the MPT PDX model can be a useful tool for studying the pathogenesis of fibroepithelial neoplasms and for preclinical drug screening to find new therapeutic strategies for MPT.

in children aged 18 years or younger include simple fibroadenoma (70%–90% of cases) and giant juvenile fibroadenoma (0.5%–2% of cases).[2]Fibroadenomas have been associated with Beckwith-Wiedemann, Maffucci, and Cowden syndromes.[2]Other benign breast masses include tubular adenomas, benign phyllodes tumors, and benign fibroepithelial neoplasms.[4]Clinical PresentationFibroadenoma usually presents

Onychomatricoma: a clinicopathological, immunohistochemical and molecular study of 10 cases highlighting recurrent RB1 deletion and the potential diagnostic value of LEF-1. Onychomatricoma (OM), an uncommon benign fibroepithelial neoplasm of the nail unit, is sometimes diagnostically challenging for clinicians and pathologists. OM consistently expresses CD34, but no specific immunohistohemical

Recurrence is Not Associated with Margin Status in Phyllodes Tumor. Phyllodes tumor (PT) is a rare fibroepithelial neoplasm of the breast. The proper extent of resection is still under debate. This study aimed to investigate the optimal surgical margin to prevent recurrence after surgery for PT and to evaluate risk factors for local recurrence (LR). Retrospective analysis of a prospective cohort

Phyllodes tumour evidence gaps mapped from the 5th edition of the WHO classification of tumours of the breast. Breast phyllodes tumours (PT) are a rare subset of fibroepithelial neoplasms categorised into benign, borderline, and malignant grades according to the World Health Organization (WHO) Classification of Tumours (WCTs). In this report, we developed an evidence gap map (EGM) based

Margin Status and Local Recurrence in Phyllodes Tumours of the Breast: A Canadian Series. Phyllodes tumours of the breast are rare fibroepithelial neoplasms with a propensity for recurrence. While surgical excision remains the standard of care, the optimal margin width is an area of active investigation. Recent studies have questioned the necessity for wide, local excision. We conducted

Predicting Outcome in Mammary Phyllodes Tumors: Relevance of Clinicopathological Features. Phyllodes tumors (PTs) of the breast are uncommon fibroepithelial neoplasms. Most behave in a benign fashion but they also have the potential to recur locally or to metastasize. In the current study involving 290 PTs (181 benign, 76 borderline, and 33 malignant) from three hospitals over an 11-year period

Expression of biomarkers in the AKT pathway correlates with malignancy and recurrence in phyllodes tumours of the breast. Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms with the potential to recur and metastasise. Apart from histological grading, the expression of biological markers and its relationship with tumour behaviour have been topics of interest

Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women. Phyllodes tumor or cystosarcoma phyllodes is a rare fibroepithelial neoplasm which arises from the periductal stroma of the breast. They are classified as benign, borderline, and malignant based on the histologic features. However, all phyllodes tumor (PT) subtypes are regarded as having malignant

Inflamed Phylloides Tumour in a Girl: A Challenging Diagnosis in Paediatric Breast Lesions : Phylloides tumours (PTs) are rare fibroepithelial neoplasms that account for 0.3⁻0.9% of all breast tumours. These tumours typically occur in women aged 30⁻70 years. The occurrence of these tumours in older children and adolescents poses particular diagnostic and therapeutic problems. However, early

Phyllodes tumor of the breast with nipple discharge: A case report. Phyllodes tumors (PTs) of the breast are rare biphasic fibroepithelial neoplasms which usually present with unilateral palpable breast lumps. Here we reported a case of borderline PTs with multifocal intraductal lesions whose primary clinical manifestation was nipple discharge. A rare case of PT with nipple discharge in a 26

Target Enrichment System. Twenty-five conventional and 17 juvenile fibroadenomas were studied, with MED12 mutations found in 53.8 and 35% of the tumours, respectively. There was also one benign fibroepithelial neoplasm with hybrid features of juvenile papillomatosis and infarcted benign phyllodes tumour-like areas. Most tumours did not have mutations in well-known cancer driver genes, none harboured

Effects of Radiotherapy in Borderline and Malignant Phyllodes Tumors After R0 Resection Breast phyllodes tumors (PT) are rare fibroepithelial neoplasms originating from stromal tissue and account for less than 1% of all breast tumors. The World Health Organization (WHO) classifies PT into benign, borderline, and malignant subtypes based on pathological features such as mitotic activity, cellular

Malignant Epithelial Transformation in Phyllodes Tumor: A Population-Based Case Series Background Phyllodes tumor (PT) of the breast is an uncommon fibroepithelial neoplasm. Malignant epithelial transformation in PT is rare. This study reports clinicopathologic characteristics and outcomes of patients with malignant epithelial transformation in PT. Methods From an institutional database of 183

Benign Phyllodes Tumor With Cystic Squamous Metaplasia: A Cytohistological Correlation of a Rare Case Phyllodes tumors (PTs) are uncommon biphasic fibroepithelial neoplasms of the breast occurring in elderly females with a peak incidence between 45 and 49 years. Depending on various histological criteria, they are subdivided into benign, borderline, and malignant forms. Metaplastic changes occur

Reconstructive and Oncoplastic Surgery for Giant Phyllodes Tumors: A Single Center’s Experience Phyllodes tumors are biphasic fibroepithelial neoplasms of the breast. While the surgical management of these relatively uncommon tumors has been addressed in the literature, few reports have commented on the surgical approach to tumors greater than ten centimetres in diameter - the giant phyllodes

Resection and reconstruction following recurrent malignant phyllodes–Case report and review of literature Phyllodes tumors are uncommon biphasic fibroepithelial neoplasms of the breast of varying malignant potential occurring in middle aged women. They exhibit diverse biological behavior. Margin free excision is the mainstay of treatment. A 27 year-old lady was referred with a painless

Giant phyllodes tumor of the breast with diffuse myxoid changes in an adolescent girl: a case report Giant phyllodes tumors (PT) are an uncommon fibroepithelial neoplasm and especially rare in adolescent girls. Diagnosis is difficult not only due to the rarity of PT, but also owing to the resemblance of its clinical and imaging features with fibroadenoma. The author reports a case of a giant PT

A Clinicopathological Study of Benign Phyllodes Tumour of Breast with Emphasis on Unusual Features Benign Phyllodes Tumours (PTs) are rare fibroepithelial neoplasms that resemble fibroadenoma. But unlike fibroadenoma, benign PT can recur and both stromal & epithelial components can progress to malignancy. Contrary to earlier belief that benign PT is a stromal neoplasm and possibly arises from

Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature Phyllodes tumor (PT) is a rare type of biphasic fibroepithelial neoplasm that may coexist with a breast tumor in rare cases. In the current study, a 52-year-old female presented with a left breast lump. Mammography and sonographic examination results suggested