"Folate deficiency"

Folate deficiency Skip to main contentSkip to searchEnglish (US)EnglishPortuguês中文Log inSearchSearchHomeFolate deficiency MENULog in or subscribe to access all of BMJ Best PracticeLast reviewed:28 May 2024Last updated:21 Jun 2024Summary Folate deficiency classically presents as megaloblastic anaemia, with absence of neurological signs. Common causes include malabsorption, drugs and toxins , states of increased demand, and dietary deficiency. Hereditary folate malabsorption and other inborn errors of folate metabolism are rare causes. In early disease, haemoglobin and mean corpuscular volume are normal. In severe disease, patients present with symptomatic anaemia and pancytopenia. Maternal folate deficiency is associated with fetal neural tube defects (NTDs). Diagnosis is confirmed

Folate tests for suspected folate deficiency HomepageMain navigationContent areaSitemapSearchThe Federal Administration in treecrumb format The federal Council FDHA FOPHDE FR IT ENContact Media Jobs Easy-to-read language Sign languageFederal Office of Public Health FOPHSearchTerms A-ZTerms A-ZMain NavigationThe FOPHHealthy livingDiseasesMedicine & researchInsurancescurrent pageStrategy a possible folate deficiency. The report further examines ethical, social and organisational issues in connection with folate testing.A systematic survey of the relevant available literature (including clinical studies) revealed no direct proof of any impact of folate tests on the recipient’s health. No indirect proof could be found, either. The diagnostic accuracy of such tests has only been examined

Cobalamin (vitamin B12) and Folate Deficiency Skip to main contentSkip to main navigationSkip to side navigationAccessibility StatementMenuHome Health Practitioner & Professional Resources BC GuidelinesAbout the GuidelinesExternal Review of GuidelinesContinuing Professional Development (CPD) CreditsGuidelines by Alphabetical ListingPartner GuidelinesGuidelines Eligible for Incentive or simply B12) and folate deficiency in adults. This guideline outlines the indications for B12 testing and discusses an observed increase in B12 testing in BC. Specifically:Outpatient and inpatient laboratory test volumes for B12 investigations increased from 267,721 to 570,265 between 2013 and 2020. This resulted in an increase in annual B12 testing expenditure from $3.0 million to $5.6 million during

The relationship between folic acid deficiency and preeclampsia-like phenotypes in rats. Pre-eclampsia is a significant contributor to maternal and neonatal morbidity and mortality. However, its etiology remains elusive. More and more studies have highlighted the potential involvement of folic acid metabolism in the development of pre-eclampsia. Folic acid is known to be important for DNA synthesis and methylation processes, which are crucial during pregnancy. Disruptions in these pathways may contribute to the pathogenesis of pre-eclampsia. Clinical studies investigating associations between folic acid supplementation and pre-eclampsia produced inconsistent results. The research aims to explore the potential link between folic acid deficiency and the development of pre-eclampsia-like

Anaemia - B12 and folate deficiency CKS is only available in the UK | NICE CKS is only available in the UKThe NICE Clinical Knowledge Summaries (CKS) site is only available to users in the UK, Crown Dependencies and British Overseas Territories.CKS content is produced by Clarity Informatics Limited. It is available to users outside the UK via subscription from the Prodigy website.If you believe

Folate Testing in People With Suspected Folate Deficiency Skip to main contentAboutCollaboration/OutreachPatient/CommunityCareersContactMy CADTHFRReportsResourcesProvide InputSubmit a RequestNews & EventsWhat Does The Evidence Say About...SearchBreadcrumbHome Folate Testing in People With Suspected Folate DeficiencyCopied to clipboardFolate Testing in People With Suspected Folate Deficiency( Last Updated : March 28, 2022)Project Status:CompletedProject Line:Health Technology ReviewProject Sub Line:Rapid ReviewProject Number:RC1414-000DetailsQuestionWhat is the diagnostic accuracy of serum folate testing for the diagnosis of folate deficiency in people with suspected folate deficiency?What is the clinical utility of serum folate testing in people with suspected folate deficiency?What is the cost

Original research: Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age Serum folate deficiency and the risks of dementia and all-cause mortality: a national study of old age ====================================================================================================== * Anat Rotstein * Arad Kodesh * Yair Goldberg * Abraham Reichenberg * Stephen Z Levine ## Abstract **Background** The association between serum folate deficiency and the risk of dementia in old age is unclear, perhaps owing to small sample sizes, the competing risk of mortality or reverse causation. **Objective** To examine the associations between serum folate deficiency and the risks of incident dementia and all-cause mortality in a large national sample of older adults

Folate deficiency Folate deficiency - Symptoms, diagnosis and treatment | BMJ Best PracticeSkip to main contentSkip to search * About us * Help * Subscribe * Access through your institution * Log inBMJ Best Practice * Help * Getting started * FAQs * Contact us * Recent updates * Specialties * Calculators * Patient leaflets * Videos * Evidence * Drugs * Recent updates * Specialties include malabsorption, drugs and toxins, states of increased demand, and dietary deficiency. Hereditary folate malabsorption and other inborn errors of folate metabolism are rare causes.In early disease, haemoglobin and mean corpuscular volume are normal. In severe disease, patients present with symptomatic anaemia and pancytopenia.Maternal folate deficiency is associated with fetal neural tube defects

Folate deficiency modifies the risk of CIN3+ associated with DNA methylation levels: a nested case-control study from the ASCUS-COL trial. To our knowledge, there are very few studies evaluating if the levels of folate modify the risk of cervical intraepithelial neoplasia grade 2 and higher (CIN2+ and CIN3+) associated with the levels of HPV genome methylation, two cofactors related to single between folate or methylation levels and CIN2+ or CIN3+. The joint effect of folate levels and methylation on the risk of CIN3+ was estimated using combinations of categorical stratifications. Folate levels were significantly lower in women with CIN3+ than in other diagnostic groups (p = 0.019). The risk of CIN3+ was eight times higher (OR 8.9, 95% CI 3.4-24.9) in women with folate deficiency and high

Folate deficiency increases the incidence of dolutegravir-associated foetal defects in a mouse pregnancy model. Dolutegravir (DTG) is a recommended first-line regimen for all people with Human Immunodeficiency Virus (HIV) infection. Initial findings from Botswana, a country with no folate fortification program, showed an elevated prevalence of neural tube defects (NTDs) with peri-conceptional exposure to DTG. Here we explore whether a low folate diet influences the risk of DTG-associated foetal anomalies in a mouse model. C57BL/6 mice fed a folate-deficient diet for 2 weeks, were mated and then randomly allocated to control (water), or 1xDTG (2.5 mg/kg), or 5xDTG (12.5 mg/kg) both administered orally with 50 mg/kg tenofovir disoproxil fumarate 33.3 mg/kg emtricitabine. Treatment

Folate deficiency may increase the risk for elevated TSH in patients with type 2 diabetes mellitus. Type 2 diabetes mellitus (T2DM) and thyroid dysfunction (TD) are two common chronic endocrine disorders that often coexist. Folate deficiency has been reported to be related with the onset and development of T2DM. However, the relationship between folate deficiency and TD remains unclear ), and folate deficiency was defined as a serum folate concentration < 4.4 ng/mL. Ordinary least squares regression models were used to assess the association of serum folate with TSH concentration. Multivariable logistic regression models were performed to explore the correlation of folate deficiency and the risk for elevated TSH. 15.3% of T2DM patients had TD. Among those patients with TD, 80.5% had

Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy? Prenatal exposure to antiseizure medication (ASM) may lead to low plasma folate concentrations and is associated with impaired neurodevelopment. To examine whether maternal genetic liability to folate deficiency impairment was obtained from parent-reported questionnaires. Using logistic regression, we examined the interaction between prenatal ASM exposure and maternal genetic liability to folate deficiency expressed as polygenic risk score (PRS) of low folate concentrations or maternal rs1801133 genotype (CC or CT/TT) on risk of language impairment or autistic traits. We included 96 children of women with ASM

Folate deficiency disturbs PEG10 methylation modifications in human spina bifida. Paternally expressed gene 10 (PEG10) is believed to be a key imprinted gene involved in placenta formation. However, its role in human folate-related spina bifida (SB) remains unclear. The methylation status of the germline differentially methylated region (gDMR) in the PEG10/sarcoglycan epsilon (SGCE) imprinted cluster was compared between SB patients and control samples. Moreover, the influence of ectopic PEG10 expression on apoptosis was assessed to explore the underlying mechanisms related to folate deficiency-induced aberrant gDMR methylation in SB. The case group exhibited a significant increase in the methylation level of the gDMR and a marked reduction in the mRNA and protein expression of PEG10

Implication of folate deficiency in CYP2U1 loss of function. Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenic mechanisms remains sparse, and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 gene, loss of which is known to be involved in a complex form of these diseases in humans. We showed

Cardiovascular manifestations of intermediate and major hyperhomocysteinemia due to vitamin B12 and folate deficiency and/or inherited disorders of one-carbon metabolism: a 3.5-year retrospective cross-sectional study of consecutive patients. The association of moderate hyperhomocysteinemia (HHcy) (15-30 μmol/L) with cardiovascular diseases (CVD) has been challenged by the lack of benefit recruited. Among them, 84% (138/165) had Hcy >30 μmol/L, 27% Hcy >50 μmol/L (44/165) and 3% Hcy >100 μmol/L (5/165). HHcy was related to vitamin B12 and/or folate deficiency in 55% (87/165), mutations in one or more genes of one-carbon and/or vitamin B12 metabolisms in 11% (19/165), and severe renal failure in 15% (21/141) of the studied patients. HHcy was the single vascular risk retrieved in almost 9

Diagnosis of B12 and folate deficiency Diagnosis of B12 and folate deficiency Guidelines for the diagnosis and treatment of cobalamin and folate disorders - Devalia - 2014 - British Journal of Haematology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our . Search within Search term Search term The full text of this article hosted on investigation and diagnosis of cobalamin and folate deficiencies (British Committe for Standards in Haematology, ) were published 20 years ago and this update reflects changes in diagnostic and clinical practice. Table 1. Summary of the causes of cobalamin and folate deficiency. Population Sector Cause Cobalamin deficiency Folate deficiency All ages Infections H.pylori , Giardia lamblia , fish tapeworm

Folate Deficiency Inhibits Development of the Mammary Gland and its Associated Lymphatics in FVB Mice. Folate is essential for DNA synthesis, DNA repair, cell proliferation, development, and morphogenesis. Folic acid (FA) is a nutritional supplement used to fortify human diets. We investigated the effects of dietary FA on early mammary gland (MG) development and hyperplasia. Study 1: nulliparous size by 20% (P < 0.0001) and increased MG insulin-like growth factor 2 mRNA by 200% (P < 0.05) and protein by 130%-150% (P < 0.05). Study 2: the Def diet did not affect MG growth, but it did reduce supramammary lymph node size (P < 0.05), spleen weight (P < 0.001), and thymic medulla area (P < 0.05). In utero and postnatal folate deficiency reduced the isometric development of the MGs and early MG

Joint effects of mitochondrial DNA⁴⁹⁷⁷ deletion and serum folate deficiency on coronary artery disease in type 2 diabetes mellitus. The 4977-bp mitochondrial deletion (mtDNA deletion), as a hallmark of mitochondrial oxidative damage, may play an important role in coronary artery disease (CAD), but its interaction with folate deficiency among diabetic patients is largely unknown. We of high mtDNA deletion (top tertile) and folate deficiency (serum folate < 6 ng/mL) was associated with more than 2-fold increased odds of having obstructive CAD and higher degrees of coronary stenosis. Prospectively, the hazard ratio for all-cause death at 1-year after PCI was up to 2.37 (95% CI: 1.21-4.63) for folate-deficient participants in the top tertile of mtDNA deletion. In HASMCs, the adverse

CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. Cerebral folate deficiency (CFD) syndrome is characterised by a low concentration of 5-methyltetrahydrofolate in cerebrospinal fluid, while folate levels in plasma and red blood cells are in the low normal range. Mutations in several folate pathway genes, including

DNA methylome of human neonatal umbilical cord: Enrichment of differentially methylated regions compared to umbilical cord blood DNA at transcription factor genes involved in body patterning and effects of maternal folate deficiency or children's sex. The DOHaD (developmental origins of health and disease) hypothesis claims that fetal malnutrition or exposure to environmental pollutants may