Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate FungalKeratitis. Fungalkeratitis (FK) remains a treatment challenge, necessitating new therapeutic targets. Piezo1, a mechanosensitive ion channel, regulates calcium signaling and immune cell function. This study investigates its role in macrophage-mediated antifungal responses in FK. Piezo1 and Pyrin expression
Phaeoisaria sp. fungalkeratitis resembling corneal rust residue: a case report. Fungalkeratitis can develop after plant injury or after prolonged glucocorticoid use. Typical manifestations include corneal infiltrates, satellite lesions, plaques, and an immune ring. Some cases exhibit atypical signs, requiring reliance on etiological examination. Notably, fungi previously deemed nonpathogenic
Trends and Clinical Outcomes of FungalKeratitis in Canada: a 20-year Retrospective Multicentre Study. An increase in fungal and particularly filamentous keratitis has been observed in many geographic areas, mostly in contact lens wearers. This study seeks to characterize long-term trends in fungalkeratitis in a continental climate area to provide guidance for diagnosis and treatment . Retrospective multicentric case series. Cases of microbiology-confirmed fungalkeratitis from 2003 to 2022 presenting to tertiary care centers across Canada were included. Charts were reviewed for patient demographics, risk factors, visual acuity, and treatments undertaken. A total of 138 patients were identified: 75 had yeast keratitis while 63 had filamentous keratitis. Patients with yeast keratitis had
Prevalence and Features of FungalKeratitis Among US Patients With Commercial Health Insurance. This cases series estimates fungalkeratitis prevalence among US patients with commercial insurance.
Aspergillus fumigatus Hypoxia Adaptation Is Critical for the Establishment of FungalKeratitis. The poor visual outcomes associated with fungalkeratitis (FK) underscore a need to identify fungal pathways that can serve as novel antifungal targets. In this report, we investigated whether hypoxia develops in the FK cornea and, by extension, if fungal hypoxia adaptation is essential for virulence
Causative Agents of FungalKeratitis in Northeastern Iran: A 3-Year Tertiary Care Hospital Study. Infectious keratitis is a significant ocular disease that, if left untreated, can lead to blindness. Fungi are among the causative agents that can result in severe symptoms. Keratitis infections are prevalent globally, with a higher incidence reported in tropical and subtropical regions. The current research focused on the molecular diagnosis of fungalkeratitis and its prevalence over a 3-year period in northeastern Iran. The study involved the collection of 38 corneal scraping specimens from the Eye Specialized Hospital of Khatam in Mashhad, northeastern Iran. These specimens were cultured on Sabouraud dextrose agar, and the isolates were identified using DNA-based techniques. Among the patients
Evaluation of liposomal amphotericin B for the treatment of fungalkeratitis in a tertiary eye care hospital. To evaluate the efficacy of liposomal amphotericin B (L-AMB) for the treatment of fungalkeratitis. Patients with fungalkeratitis confirmed by potassium hydroxide (KOH) smear and/or confocal microscopy were administered topical L-AMB and randomized into three groups treated with three
Time-Course Transcriptomic Analysis Reveals the Crucial Roles of PANoptosis in FungalKeratitis. Fungalkeratitis (FK) is a serious corneal infection with high morbidity. Host immune responses function as a double-edged sword by eradicating fungal pathogens while also causing corneal damage, dictating the severity, progression, and outcome of FK. However, the underlying immunopathogenesis
Development and multi-center validation of machine learning model for early detection of fungalkeratitis. Fungalkeratitis (FK) is a leading cause of corneal blindness in developing countries due to poor clinical recognition and laboratory identification. Here, we aimed to identify the distinct clinical signature of FK and develop a diagnostic model to differentiate FK from other types
Continuous voriconazole lavage in managing moderate and severe fungalkeratitis: a randomized controlled trial. To assess the effectiveness and safety of continuous lavage with 1% voriconazole (CL) for moderate and severe fungalkeratitis. Thirty-one patients were randomized to receive topical eye drops either alone (T) or combined with continuous 1% voriconazole lavage (CL-T). The primary outcome was the cure rate at 3 months. The secondary outcomes were the 6-day efficacy, 3-day infiltration size and depth, hypopyon height, central corneal thickness (CCT), epithelial defect size, and subject feelings and clinical signs assessment scores. At 3 months, the cure rate was comparable between the groups in patients with moderate fungalkeratitis (66.7% vs. 62.5%, P = 0.60). However, among
Natamycin versus natamycin combined with voriconazole in the treatment of fungalkeratitis. To observe the therapeutic effect of natamycin combined with voriconazole in the treatment of fungalkeratitis (FK). This is a retrospective study. The subjects of this study were 64 patients with FK who were admitted to Baoding No.1 Central Hospital from February 2019 to July 2022. The enrolled patients
Dematiaceous FungalKeratitis With Tentacles Mimicking Pythium Keratitis. This case report describes a diagnosis of Curvularia fungalkeratitis in a man aged 60 years who presented with a paracentral corneal infiltrate in the right eye with tentacular projections.
Diagnosis of fungalkeratitis caused by Nectria haematococca through next-generation sequencing: review of literature and report of three cases. Fungalkeratitis (FK) is a kind of serious corneal infection and penetrating keratoplasty (PKP) is needed when medical therapy fails. Although Nectria haematococca is found as endophytes in the roots of some plant species, there has been no report of N
Therapeutic Effect of Corneal Crosslinking on FungalKeratitis: Efficacy of Corneal Collagen Crosslinking as an Adjuvant Therapy for FungalKeratitis in a Tertiary Eye Hospital in South India. To evaluate the efficacy of CXL in treating fungalkeratitis as an adjuvant therapy. Detailed clinical examination microbiological investigation was performed. Twenty fungalkeratitis patients were was better for group 2. Expression of IL-1β, IL-8, IFN-γ significantly decreased immediately post CXL in group 2 patients. Significant downregulation of TLR 6, TLR-3, TLR-4 was observed 3-days post CXL compared to group 1 patients. Adjuvant effect of CXL was significant in treating fungalkeratitis compared to standalone antifungal treatment.
Fungalkeratitis: Mechanisms of infection and management strategies. Fungal corneal ulcers are an uncommon, yet challenging, cause of vision loss. In the United States, geographic location appears to dictate not only the incidence of fungal ulcers, but also the fungal genera most encountered. These patterns of infection can be linked to environmental factors and individual characteristics explore the biology of Candida, Fusarium, and Aspergillus, the three most common genera of fungi causing corneal ulcers in the United States and discuss current treatment regimens for the management of fungalkeratitis.
Topical Chlorhexidine 0.2% versus Topical Natamycin 5% for the Treatment of FungalKeratitis in Nepal: A Randomized Controlled Noninferiority Trial. To investigate if topical chlorhexidine 0.2%, which is low cost and easy to formulate, is noninferior to topical natamycin 5% for the treatment of filamentous fungalkeratitis. Randomized controlled, single-masked, noninferiority clinical trial , after adjusting for baseline ulcer depth (odds ratio, 0.34; 95% CI, 0.15-0.79; P = 0.013). Treatment with natamycin is associated with significantly better visual acuity, with fewer adverse events, compared with treatment with chlorhexidine. Natamycin remains the preferred first-line monotherapy treatment for filamentous fungalkeratitis.
Clinical Investigation of the Safety and Efficacy of Low-temperature Plasma as an Adjuvant Treatment for Mild to Moderate FungalKeratitis: A Pilot Study. This pilot study assessed the safety and efficacy of low-temperature plasma (LTP) as an adjuvant treatment for mild to moderate fungalkeratitis (FK). Thirty FK patients were randomized into LTP (n = 15) and control (n = 15) groups. Patients
Patterns of Antifungal Resistance in Adult Patients With FungalKeratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials. Antifungal resistance has been shown to impact treatment success, but research analyzing antifungal resistance is scarce. To evaluate changes in antifungal resistance over time. Ad hoc analysis of 3 randomized clinical trials including consecutive , 1.04-1.10; P < .001). This post hoc analysis suggests that susceptibility to both natamycin and voriconazole may be decreasing over the last decade in South India. While a trend of increasing resistance could impact treatment of mycoses in general and infectious fungalkeratitis in particular, further study is needed to confirm these findings and determine their generalizability to other regions
Expert Performance in Visual Differentiation of Bacterial and FungalKeratitis. This study quantifies the performance of an international cohort of cornea specialists in image-based differentiation of bacterial and fungalkeratitis, identifying significant regional variation and establishing a reference standard for comparison against machine learning models.
A 5-Year Retrospective Analysis of the Risk Factors, Treatment, and Prognosis of Patients With FungalKeratitis in Heilongjiang, China. To report the epidemiologic features, laboratory findings, and treatment outcomes of patients with fungalkeratitis (FK) during a busy farming period (May, June, and September to November) in Heilongjiang Province, China. Retrospective, observational case series