30-day Morbidity and Mortality after Cholecystectomy for Benign GallbladderDisease (AMBROSE): A Prospective, International Collaborative Cohort Study. This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladderdisease and identify the factors associated with complications. Although cholecystectomy is common for benign gallbladderdisease , there is a gap in the knowledge of the current practice and variations on a global level. A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladderdisease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used
Hypoglycemic drugs, circulating inflammatory proteins, and gallbladderdiseases: A mediation mendelian randomization study. The relationship of hypoglycemic drugs, inflammatory proteins and gallbladderdiseases remain unknown. Four hypoglycemic drugs were selected as exposure: glucagon-like peptide-1 receptor agonists (GLP-1RA), dipeptidyl peptidase-4 inhibitors (DPP-4i), sodium-glucose cotransporter 2 inhibitors (SGLT-2i), and metformin. The outcome were two gallbladderdiseases: cholecystitis and cholelithiasis. Mendelian Randomization (MR) was employed to determine the association between hypoglycemic drugs and gallbladderdiseases. DPP-4i and SGLT-2i had no effect on cholecystitis and cholelithiasis. However, a causal relationship was found between inhibition of ETFDH gene, a target
Panacreatic cancer risk after benign gallbladderdisease: A Swedish population-based cohort study. The purpose of this nationwide registry-based cohort study was to outline pancreatic cancer risk after benign gallbladderdisease (GBD). Anatomically adjacent cancers were investigated to address incidental findings. We included all Swedes aged 20-79 years with histologically confirmed GBD
Gallbladderdisease is associated with the risk of cardiovascular disease among Uyghurs in Xinjiang: a prospective cohort study. Gallbladderdisease (GBD) can increase the risk of cardiovascular disease (CVD). However, GBD has rarely been reported in the less developed, rural areas of Xinjiang. This study aimed to determine the prevalence of GBD and incidence of CVD in a prospective cohort study
GallbladderDisease and Risk of Type 2 Diabetes in Postmenopausal Women: A Women's Health Initiative Study. Studies have suggested that adults with gallbladderdisease have increased risk of type 2 diabetes. This prospective cohort study assessed the risk of type 2 diabetes in postmenopausal women with gallbladderdisease. Data from women enrolled in the Women's Health Initiative from 1993 to 2005, aged 50-79 years (mean = 63.2; standard deviation, 7.2), were analyzed. Cox proportional hazards regression models were used to estimate the risk of type 2 diabetes associated with gallbladderdisease. There were 8,896 new cases of type 2 diabetes after 1,025,486 person-years of follow-up. Gallbladderdisease was significantly associated with type 2 diabetes (hazard ratio = 1.52; 95% confidence
Clinical significance of preoperative antibiotic use in mild to moderate acute inflammatory gallbladderdisease: A randomized controlled trial. Many patients receive empirical antibiotics for the prevention of postoperative infectious complications following cholecystectomy due to acute cholecystitis (AC). The purpose of this study was to investigate the clinical significance of preoperative
Association of gallbladderdiseases with risk of gastrointestinal polyps. It has not yet been determined whether gastroscopy and colonoscopy screening help patients with gallbladderdiseases. We aim to retrospectively investigate the relationship between gallbladderdiseases and gastrointestinal polyps in order to provide a theoretical basis for the early screening of gastrointestinal polyps in patients with gallbladderdisease. This is a retrospective cross-sectional study involving 1662 patients who underwent gastroscopy, colonoscopy, and abdominal ultrasound as part of their health check-up from January 2015 to July 2020. We also compared the patients with and without gallbladderdiseases to determine the prevalence of gastrointestinal polyps. Patients with gallbladder polyps had greater
Randomised controlled trial to establish the clinical and cost-effectiveness of expectant management versus preoperative imaging with magnetic resonance cholangiopancreatography in patients with symptomatic gallbladderdisease undergoing laparoscopic cho Surgery to remove the gallbladder (laparoscopic cholecystectomy (LC)) is the standard treatment for symptomatic gallbladderdisease. One potential complication of gallbladderdisease is that gallstones can pass into the common bile duct (CBD) where they may remain dormant, pass spontaneously into the bowel or cause problems such as obstructive jaundice or pancreatitis. Patients requiring LC are assessed preoperatively for their risk of CBD stones using liver function tests and imaging. If the risk is high, guidelines recommend further
Study on the Relation between Colorectal Cancer and GallBladderDisease Colorectal cancer is cancer of the large intestine, the lower part of digestive system which includes the sigmoid colon and rectum. To study the relation of incidence of colorectal cancer with previous gallbladderdisease or post-cholecystectomy status, a relation between gallbladderdisease and smoking in particular and the most common region of colon involved in colorectal cancer in gallbladderdisease and non-gallbladderdisease patients. A total of 256 patients with symptoms of rectal bleeding, change in bowel habit, unexplained tiredness, weight loss, pelvic pain, jaundice and abdominal distension were screened by using colonoscopy among whom 30 patients were diagnosed with colorectal cancer. Detailed history
Effectiveness of Bael (Aegle marmelos) in regulating various biomarkers related to Liver and Gallbladderdiseases: A systematic review and meta analysis PROSPEROInternational prospective register of systematic reviews Print | PDFEffectiveness of Bael (Aegle marmelos) in regulating various biomarkers related to Liver and Gallbladderdiseases: A systematic review and meta analysisSHUBHAM SHARMA biomarkers related to Liver and Gallbladderdiseases: A systematic review and meta analysis. PROSPERO 2023 CRD42023465969 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023465969Review questionIs Bael (Aegle marmelos) a viable natural alternative to adjust the biomarkers of Liver and Gall bladder in clinical way, and improve its functions.SearchesSources: PubMed, Embase
Routine Pathology and Postoperative Follow-Up are Not Cost-Effective in Cholecystectomy for Benign GallbladderDisease. The incidence of gallstone disease is increasing and represents a strain on healthcare systems worldwide. Following cholecystectomy, gallbladder specimens are generally submitted for histopathologic examination and the diagnostic yield of this strategy remains questionable
Association of Bile Duct and GallbladderDiseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus The use of dipeptidyl-peptidase-4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) analogues-a group of drugs used in the management of type 2 diabetes mellitus-may be associated with an increased risk of bile duct and gallbladderdisease. To date , no observational study has assessed this possible association. To determine whether the use of DPP-4 inhibitors and GLP-1 analogues is associated with an increased risk of incident bile duct and gallbladderdisease in patients with type 2 diabetes. A population-based cohort study linked the United Kingdom Clinical Practice Research Datalink with the Hospital Episodes Statistics database, yielding a cohort
Association between helicobacter pylori infection and gallbladderdiseases: a retrospective study. The association between Helicobacter pylori (H. pylori) and gallbladderdiseases is still unclear and is controversial. We conducted a retrospective study to clarify the prevalence of gallbladderdiseases and factors related to gallbladderdiseases and relationships between H. pylori infection , gallstones, cholecystitis, and cholecystic polypus. The retrospective study was performed at the Aerospace Center Hospital in Beijing. The subjects in this study were a healthy population who underwent health examinations at the hospital between 2012 and 2015. The logistic regression models were used to explore the relationships between H. pylori infection and gallbladderdiseases. There were 7803 (43.4
Sex and ethnic/racial-specific risk factors for gallbladderdisease. Gallbladderdisease (GBD) is a highly prevalent condition; however, little is known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive and obesity-related factors and GBD in multiethnic populations. We performed a prospective analysis from the Multiethnic Cohort
Association between dietary intake and postlaparoscopic cholecystectomic symptoms in patients with gallbladderdisease After cholecystectomy, patients have reported postcholecystectomic syndromes such as abdominal symptoms, dyspepsia, and diarrhea, which suggest a relationship between cholecystectomic symptoms and diet, although the details of this association remain unclear. The present study
UCAD for Diagnosing Benign or Malignant GallbladderDiseases and Follow-up Copy number variation(CNV) refers to ongoing chromosome segregation errors throughout consecutive cell divisions. CNV is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. Analyzing CNV of the DNA extracted from bile samples in gallbladder seems a promising method
Vegetable protein intake is associated with lower gallbladderdisease risk: findings from the Women's Health Initiative prospective cohort. This study aimed to measure associations between gallbladderdisease and protein intake patterns, separated by quantity and type (vegetable vs. animal), among postmenopausal women. Analyses were based on 130,859 postmenopausal women enrolled from 1993 to 1998 at 40 U.S. clinical centers in the Women's Health Initiative clinical trials and observational study. Women were excluded if they reported a history of gallbladderdisease prior to baseline. Cox proportional hazards regression models, adjusted for gallbladderdisease risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between energy
The increasing incidence of gallbladderdisease in children: A 20year perspective. The incidence of cholecystectomy in the pediatric population has increased over the last 20years but has not been described in a Canadian population. We conducted the first province-wide study to describe the incidence of cholecystectomy in children in Ontario. A population-based, retrospective cohort using in the incidence of pediatric cholecystectomy in Ontario over the last 20years. The majority of surgeries are performed in the community, and pediatricians will likely see an increase of gallbladderdisease in practice.
Management of gallbladderdisease after sleeve gastrectomy in a selected Lebanese population. Patients with morbid obesity are at a higher risk of developing gallstones after bariatric surgery. Studies on the incidence of symptomatic gallstones necessitating cholecystectomy after laparoscopic sleeve gastrectomy (LSG) are limited in the Middle East. This study aims to assess the incidence