"Granuloma annulare"

Emerging Role of Janus Kinase Inhibitors in Treating Granuloma Annulare: A Clinical, Narrative Review of Efficacy and Safety. Granuloma annulare (GA) is a non-infectious, granulomatous skin disease with an unknown pathoetiology whose treatment remains challenging. In recent decades, the Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway have been implicated

Is granuloma annulare associated with food allergy or alpha-gal syndrome? Cookie NoticeThis site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our cookies information for more details.OKskip to main contentToggle site navigationAllergist Resources Ask The Expert 2022 Is Granuloma Annulare Associated With Food Allergy Or Alpha-Gal Syndrome ?Is granuloma annulare associated with food allergy or alpha-gal syndrome?Question:11/30/2022A 78-year-old male developed a generalized painful, pruritic rash in July. Dermatology work-up in September included an alpha gal level which returned >100 kU/L. Skin biopsy returned as granuloma annulare, for which he is now being treated. Dermatology advised he refrain from meat and milk products. The patient

Oral abrocitinib in the treatment of granuloma annulare: a case report. To evaluate the therapeutic efficacy and safety of JAK inhibitor abrocitinib in patients with localized granuloma annulare (GA) and to review the available cases documented in English. We presented a patient who had a persistent, localized granuloma anulare (GA) for one year and did not respond to traditional therapies

Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics. Granuloma annulare (GA) is an idiopathic condition characterized by granulomatous inflammation in the skin. Prior studies have suggested that GA develops from various triggers, leading to a complex interplay involving innate and adaptive immunity, tissue remodeling, and fibrosis

Granuloma annulare Granuloma annulare - Symptoms, diagnosis and treatment | BMJ Best PracticeSkip to main contentSkip to search * About us * Help * Subscribe * Access through your institution * Log inBMJ Best Practice * Help * Getting started * FAQs * Contact us * Recent updates * Specialties * Calculators * Patient leaflets * Videos * Evidence * Drugs * Recent updates , and diabetes.DefinitionGranuloma annulare (GA) is an uncommon benign condition of unknown aetiology.[1]Muhlbauer JE. Granuloma annulare. J Am Acad Dermatol. 1980 Sep;3(3):217-30.http://www.ncbi.nlm.nih.gov/pubmed/7005273?tool=bestpractice.com Lesions are typically described as dermal papules, which coalesce to form rings, and may be skin-coloured, pink, or violaceous; commonly found on the back of hands, ankles, knees

The association of anxiety with granuloma annulare: a case-control study of the National Institutes of Health 'All of Us' research programme. Dear Editor, Granuloma annulare (GA) is an inflammatory skin disease that has been associated with diabetes, dyslipidaemia, hypothyroidism and autoimmune disorders.1,2 The annualized incidence and prevalence of GA in the USA are approximately 0.04% and 0.06

Retrospective assessment of immunologic and histologic heterogeneity in granuloma annulare by cytokine staining. Type 1 (Th1) and Type 2 (Th2) immunity have both been implicated in granuloma annulare (GA). To what extent these pathways contribute to clinical/histologic heterogeneity and/or distinct disease endotypes remains unexplored. We retrospectively analyzed 30 GA biopsies with either

Generalized granuloma annulare resolution following biopsy: a remote reverse Koebner phenomenon. This generalized granuloma annulare case of palisading type, with extensive lesions of 10 months duration resolving 1 week post biopsy without any treatment is the most exceptional depiction of this poorly understood remote reverse Koebner phenomenon.

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options. Granuloma annulare (GA) is an inflammatory granulomatous skin disease that can be localized (localized GA) or disseminated (generalized GA), with patch, perforating, and subcutaneous subtypes being less common variants of this benign condition. Recently, new research has emerged that further elucidates GA

Granuloma annulare skin profile shows activation of T-helper cell type 1, T-helper cell type 2, and Janus kinase pathways. Granuloma annulare (GA) is an inflammatory skin disorder. Localized GA is often self-resolving, but generalized GA is often recalcitrant to treatments. There are no targeted treatments for GA, largely due to lack of mechanistic understanding. Recently, tumor necrosis factor

Granuloma annulare: report of 13 patients treated with photodynamic therapy.

Peri and intraneural mucinosis in painful, interstitial granuloma annulare of the digit.

Treatment of granuloma annulare and related granulomatous diseases with sulphasalazine: a series of 16 cases. Granuloma annulare (GA) and the related annular elastolytic giant cell granuloma (AEGCG) and interstitial granulomatous dermatitis (IGD) are idiopathic histiocytic inflammatory disorders, which are frequently recalcitrant to treatment. Evaluate the efficacy of sulphasalazine in treating

Granuloma Annulare We value your privacyWe and our partners store and/or access information on a device, such as cookies and process personal data, such as unique identifiers and standard information sent by a device for personalised ads and content, ad and content measurement, and audience insights, as well as to develop and improve products. With your permission we and our partners may use ProfessionalsProfessional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find one of our health articles more useful.Read COVID-19 guidance from NICEIN THIS ARTICLEWhat is granuloma annulare?Granuloma annulare causes (aetiology)How common is granuloma annulare? (Epidemiology

Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare. Sarcoidosis and granuloma annulare (GA) are cutaneous granulomatous disorders that can be difficult to treat. There is evidence of underlying Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway activation in sarcoidosis, suggesting that JAK inhibition might to characterize patterns of JAK-STAT pathway activation. Tofacitinib resulted in a mean improvement in the baseline Cutaneous Sarcoidosis Activity and Morphology Instrument and Granuloma Annulare Scoring Index scores of 96% (standard deviation, 2%). Histologic resolution of disease was documented in all patients (3 out of 3) who had skin biopsies while receiving therapy. Constitutive STAT1 and STAT3 activation

Granuloma annulare: strengthening potential associations and pentoxifylline as a therapeutic option. Granuloma annulare is frequently described in association with numerous systemic conditions and is often refractory to treatment. This retrospective review explored a large patient cohort to further strengthen associated comorbid conditions and assess response to different treatments in patients with granuloma annulare. This study found that patients with granuloma annulare frequently carried a diagnosis of hypothyroidism. Additionally, the highest rate of improvement in any treatment category was seen with pentoxifylline use. Thus, should be further explored as a first-line therapeutic option in the treatment of granuloma annulare.

Clinical and Histopathological Features of Paraneoplastic Granuloma Annulare in Association with Solid Organ Malignancies: Case Control Study. Granuloma annulare (GA) is a granulomatous skin eruption rarely associated with cancer. We report seven cases of paraneoplastic GA in association with solid organ malignancy. To compare the clinical and histopathological features of paraneoplastic GA

Methotrexate treatment of generalized granuloma annulare: A retrospective case series. Management of generalized granuloma annulare (GGA) poses challenges for both patients and dermatologists. Currently, there are no established first-line therapies for GGA and the available therapeutic modalities are based on individual case reports and a few small case series. Further, there are limited

Granuloma Annulare and Radial Pulse Therapy: Preliminary Findings In this case report, the authors describe a first-time trial of a variation of extracorporeal shockwave therapy in a patient with disseminated granuloma annulare. Radial pulse therapy was administered in an outpatient clinic of a university hospital to a 72-year-old woman with a 14-year history of disseminated granuloma annulare . The authors describe changes in clinical appearance and results of histological evaluation, reporting observable positive changes in all four treated plaques. The authors conclude that radial pulse therapy was well-tolerated and seemed to influence the course of disseminated granuloma annulare plaques positively.

Programmed cell death protein-1 inhibitor–induced granuloma annulare and hypertrophic lichen planus masquerading as squamous cell carcinoma