Antibodies to Anaplasma phagocytophilum in Patients with HumanGranulocyticAnaplasmosis Confirmed by Both Polymerase Chain Reaction and Culture. Sera from patients from a single medical institution in New York State with humangranulocyticanaplasmosis established by a positive polymerase chain reaction test (PCR) for Anaplasma phagocytophilum were used to assess the performance of serologic of the antigen. From 1997-2009, 38 humangranulocyticanaplasmosis patients were evaluated. On the baseline serum sample 21 (55.3%; 95% CI: 38.3% to 71.4%) had a positive serologic test; 7 samples (33.1%) were positive at a titer of 80-320 and 14 samples (66.7%) at a titer of at least 640. Sixteen (94.1%) of the 17 with a negative baseline test had follow-up testing performed. All 16 tested positive
Using Serum Specimens for Real-Time PCR-Based Diagnosis of HumanGranulocyticAnaplasmosis, Canada. Whole blood is the optimal specimen for anaplasmosis diagnosis but might not be available in all cases. We PCR tested serum samples collected in Canada for Anaplasma serology and found 84.8%-95.8% sensitivity and 2.8 average cycle threshold elevation. Serum can be acceptable for detecting Anaplasma
Retinal Hemorrhage Associated with HumanGranulocyticAnaplasmosis. This case report describes a 51-year-old female with presented to the emergency department with high-grade fever, headache, nausea, vomiting, dizziness, diffuse arthralgias, and new-onset worsened vision that had developed over 3 days.
Rare case of severe rhabdomyolysis secondary to humangranulocyticanaplasmosis. Anaplasma phagocytophilum (AP) is the causative agent of humangranulocyticanaplasmosis (HGA), a tick-borne illness with highest incidence in north-eastern regions of the United States. This condition presents with vague constitutional symptoms and has been associated with laboratory derangements such as leukopenia
Acute Kidney Injury Associated With HumanGranulocyticAnaplasmosis: A Case Report. Tick-borne illnesses are a growing problem in the United States. Humangranulocyticanaplasmosis (HGA), carried by the Ixodes scapularis tick, is caused by Anaplasma phagocytophilum. While the clinical manifestations of HGA may be protean, ranging from asymptomatic infection to life-threatening multiorgan failure
Value of PCR, Serology, and Blood Smears for HumanGranulocyticAnaplasmosis Diagnosis, France. We prospectively examined the effectiveness of diagnostic tests for anaplasmosis using patients with suspected diagnoses in France. PCR (sensitivity 0.74, specificity 1) was the best-suited test. Serology had a lower specificity but higher sensitivity when testing acute and convalescent samples. PCR
Severe HumanGranulocyticAnaplasmosis With Significantly Elevated Ferritin Levels in an Immunocompetent Host in Pennsylvania: A Case Report Humangranulocyticanaplasmosis (HGA) is a tick-borne, infectious disease caused by that generally presents with nonspecific symptoms such as fever, chills, headache, malaise, and myalgia. If not treated immediately, HGA can cause hemophagocytic
Diagnosis, Treatment, and Prevention of Lyme Disease, HumanGranulocyticAnaplasmosis, and Babesiosis: A Review. Lyme disease, humangranulocyticanaplasmosis (HGA), and babesiosis are emerging tick-borne infections. To provide an update on diagnosis, treatment, and prevention of tick-borne infections. Search of PubMed and Scopus for articles on diagnosis, treatment, and prevention of tick-borne
Case Report: Polymerase Chain Reaction Testing of Tick Bite Site Samples for the Diagnosis of HumanGranulocyticAnaplasmosis. Humangranulocyticanaplasmosis (HGA) is a tick-borne infectious disease caused by , an obligate intracellular bacterium. Until now, the utility of tick-bite site samples for HGA diagnosis has not been reported. Using a patient's buffy coat and tick-bite site crust
HumanGranulocyticAnaplasmosis as a Cause of Febrile Illness in Korea Since At Least 2006. AbstractHuman granulocytic anaplasmosis (HGA) is a tick-borne rickettsial zoonosis with fever, thrombocytopenia, and leukopenia. HGA has been reported in Korea in 2013 but it is uncertain how long it has existed. A retrospective study was conducted on patients who underwent bone marrow examination due
Accuracy of Diagnosis of HumanGranulocyticAnaplasmosis in China. In 2008, humangranulocyticanaplasmosis (HGA) was reported from China. However, the clinical and laboratory findings, including reports of nosocomial transmission, were inconsistent with those reported for HGA in the United States. In 2012, it was demonstrated that the patients described in the 2008 report had all been infected
Clinical and laboratory features parameters of humangranulocyticanaplasmosis (HGA) in patients admitted to hospital in Guangdong Province, China. Humangranulocyticanaplasmosis (HGA) is an acute tick-borne infectious disease with increasing morbidity and mortality, but is rarely considered in clinical practice. Because human-to-human transfusion or nosocomial transmission can occur, diagnosis
HumanGranulocyticAnaplasmosis in the United States from 2008 to 2012: A Summary of National Surveillance Data. Humangranulocyticanaplasmosis is an acute, febrile illness transmitted by the ticks Ixodes scapularis and Ixodes pacificus in the United States. We present a summary of passive surveillance data for cases of anaplasmosis with onset during 2008-2012. The overall reported incidence
Humangranulocyticanaplasmosis, South Korea, 2013. We report a patient with humangranulocyticanaplasmosis in South Korea. The patient had fever and thrombocytopenia. Humangranulocyticanaplasmosis was confirmed by seroconversion, PCR, and sequence analysis for Anaplasma phagocytophilum. Morulae were observed in the cultured HL-60 cells inoculated with blood from the patient.
Diagnosis of humangranulocyticanaplasmosis in Belgium by combining molecular and serological methods We report here one new, hospitalized case of Anaplasma phagocytophilum in Belgium. The clinical presentation of anaplasmosis, its treatment and the molecular and serological relevant laboratory methods are briefly developed.
High seroprevalence of Borrelia miyamotoi antibodies in forestry workers and individuals suspected of humangranulocyticanaplasmosis in the Netherlands Substantial exposure to Borrelia miyamotoi occurs through bites from Ixodes ricinus ticks in the Netherlands, which also transmit Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum. Direct evidence for B. miyamotoi infection in European populations is scarce. A flu-like illness with high fever, resembling humangranulocyticanaplasmosis, has been attributed to B. miyamotoi infections in relatively small groups. Borrelia miyamotoi infections associated with chronic meningoencephalitis have also been described in case reports. Assuming that an IgG antibody response against B. miyamotoi antigens reflects (endured) infection
Do leukoreduction filters passively reduce the transmission risk of humangranulocyticanaplasmosis? Humangranulocyticanaplasmosis, caused by Anaplasma phagocytophilum, poses an increasing public health risk in the United States. Since 2000, case reports have increased annually; 2782 cases were reported in 2013. Despite the increasing frequency of clinical cases, only eight cases