Acetic Acid-IndigoCarmine Chromocolonoscopy for Proximal Serrated Lesions: A Randomized, Three-Arm Colonoscopy Study. Aggressive colorectal cancer (CRC) frequently originates from serrated lesions (SLs), particularly in the proximal colon, which are challenging to detect using standard screening colonoscopy. Although duplicate examinations or chromocolonoscopies are recommended for detecting proximal SLs, evidence from randomized trials is limited. We evaluated the effectiveness of tandem colonoscopy with an acetic acid-indigocarmine mixture (AIM) for detecting SLs in the proximal colon compared to white-light imaging (WLI) and indigocarmine (IC). This three-arm, multicenter, randomized controlled trial involving nine institutions enrolled patients undergoing colonoscopy and assigned them
Patent blue versus methylene blue and indigocarmine as a better dye for chromodiscography: in vitro staining efficacy and cytotoxicity study using bovine coccygeal intervertebral discs. Chromodiscography is an integral part of full-endoscopic discectomy (FED), comprising ordinary discography with radiopacity produced by contrast medium and intradiscal stain for visualizing annular defects in the endoscopic field. Nevertheless, concerns remain about the cytotoxicity of the stains used. The study of their staining efficacy is also lacking. To evaluate the feasibility of methylene blue, patent blue, and indigocarmine for intradiscal injection, investigate the effectiveness of each dye, and define critical concentration with adequate staining efficacy and tolerable cytotoxicity for use
A Randomized Clinical Trial Evaluating IndigoCarmine as a Visualization Aid for Evaluating Ureteral Patency. To determine whether intravenous indigocarmine provides a visualization advantage compared to saline in the evaluation of ureteral patency in a randomized, controlled clinical trial. Patients undergoing urological or gynecological surgical procedures in which the patency of the ureter was to be assessed received a saline injection and were randomized to receive 2.5 mL or 5.0 mL of indigocarmine. Blinded video assessments were conducted by independent reviewers using a conspicuity scale ranked 1 (poorest) to 5 (best), and subjects with scores ≥ 3 and at least a +1-point difference from saline were considered responders. Time to visualization was recorded for indigocarmine. A responder analysis
IndigoCarmine Hemodynamic Studies to Treat Vasoplegia Induced by Compound 48/80 in a Swine Model of Anaphylaxis. There are many reasons to believe that the nitric oxide/guanosine 3'5' - cyclic monophosphate (or NO/cGMP) pathway on vasoplegic states is underestimated. To study indigocarmine (IC) as an alternative to methylene blue was the investigation rationale. The IC (3mg/kg intravenous
Advanced Lymph Node Staging With Ex Vivo Intra-arterial IndigoCarmine Injection After Transanal Total Mesorectal Excision for Rectal Cancer: A Retrospective Cohort Study. Exact lymph node staging is essential in rectal cancer therapy. The aim of the study was to assess the impact of intra-arterial indigocarmine injection after transanal total mesorectal excision on the number of retrieved lymph nodes. This was a retrospective, nonrandomized study. The study was conducted at a tertiary hospital by a multidisciplinary team. Patients who underwent transanal total mesorectal excision for suspected rectal cancer between 2013 and 2019 were included. Rectal cancer specimens received ex vivo intra-arterial indigocarmine injection to stain lymph nodes. Outcome measures included the number
Chromoendoscopy With IndigoCarmine vs Virtual Chromoendoscopy (iSCAN 1) for Neoplasia Screening in Patients With Inflammatory Bowel Disease: A Prospective Randomized Study. The risk of colon cancer is greater in patients with inflammatory bowel disease (IBD) than in the general population. Chromoendoscopy with dye (CE) is the currently recommended method for detecting dysplasia in screening
Highly accurate artificial intelligence systems to predict the invasion depth of gastric cancer: efficacy of conventional white-light imaging, nonmagnifying narrow-band imaging, and indigo-carmine dye contrast imaging. Diagnosing the invasion depth of gastric cancer (GC) is necessary to determine the optimal method of treatment. Although the efficacy of evaluating macroscopic features and EUS to training and test datasets at a ratio of 4:1. Through transfer learning leveraging a convolutional neural network architecture, ResNet50, 3 independent AI systems were developed. Each system was trained to predict the invasion depth of GC using conventional white-light imaging (WLI), nonmagnifying narrow-band imaging (NBI), and indigo-carmine dye contrast imaging (Indigo). The area under the curve
Benefits of linked color imaging for recognition of early differentiated-type gastric cancer: in comparison with indigocarmine contrast method and blue laser imaging. Linked color imaging (LCI) is a novel endoscopy system, which enhances slight differences in mucosal color. However, whether LCI is more useful than other kinds of image-enhanced endoscopy (IEE) in recognizing early gastric cancer remains unclear. This study aimed to evaluate LCI efficacy compared with the indigocarmine contrast method (IC), and blue laser imaging-bright (BLI-brt) in early differentiated-type gastric cancer recognition. We retrospectively analyzed early differentiated-type gastric cancer, which were examined by all four imaging techniques (white light imaging, IC, LCI, BLI-brt) at Asahi University Hospital from
Back-to-Back Comparison of Colonoscopy With Virtual Chromoendoscopy Using a Third-Generation Narrow-Band Imaging System to Chromoendoscopy With IndigoCarmine in Patients With Lynch Syndrome. Colonoscopic screening with indigocarmine chromoendoscopy (ICC) in patients with Lynch syndrome (LS) improves the adenoma detection rate but is time consuming and poorly used in clinical practice. Narrow
Utility of indigocarmine angiography in patients with critical limb ischemia: Prospective multi-center intervention study (DIESEL-study). To assess the efficacy of indigocarmine angiography for wound healing after successful below-the-knee intervention in patients with critical limb ischemia (CLI). A multi-center prospective intervention study was conducted. Fifty-four limbs of 53 patients in Rutherford categories 5 and 6 underwent endovascular therapy (EVT). After successful EVT, 5 mL of indigocarmine was injected through a catheter at the distal popliteal artery and color changes in the foot were evaluated. The results of indigocarmine angiography were divided into three groups: In type I, the color change of the wound was deeper than the surrounding tissue; in type II, the change in wound
Comparison of the indocyanine green dye method versus the combined method of indigocarmine blue dye with indocyanine green fluorescence imaging for sentinel lymph node biopsy in breast conservative therapy for stage ≤IIA breast cancer. Fluorescence imaging (FI) is one of the methods to identify sentinel lymph nodes (SLNs). However, the procedure is technically complicated and requires procedural skills, as SLN biopsy must be conducted in dim light conditions. As an improved version of this method, we introduced a combined method (Combined mixed dye and fluorescence; CMF) consisting of indigocarmine blue dye and FI. The direct visualization of SLNs under shadowless surgical light conditions is facilitated by the addition of the blue dye. We compared the SLN detection rates of CMF
MnO2 efficiently removes indigocarmine dyes from polluted water MnO is identified as a highly efficient sonocatalyst and sonophotocatalyst for the complete removal of even very small concentration of Indigocarmine (IC) dye pollutant from water. The effect of various reaction parameters, viz. dosage of the catalyst, concentration of pollutant, volume of reaction system, pH, dissolved gases
Clinical Effectiveness of Submucosal Injection with IndigoCarmine Mixed Solution for Colon Endoscopic Mucosal Resection. Submucosal injection with indigocarmine mixed solution can improve the delineation of colorectal neoplasia during endoscopic mucosal resection (EMR). Thus, the aim of this study was to evaluate the efficacy of submucosal injection with indigocarmine mixed solution during EMR of colorectal neoplasia. This was a prospective, randomized, controlled study of a total of 212 neoplastic colon polyps (5-20 mm) subjected to EMR in a single tertiary university hospital. The patients were randomized into two groups according to whether or not indigocarmine mixed solution was used, and the complete resection rate (CRR) after EMR was evaluated. A total of 212 neoplastic polyps
Evaluating Ureteral patency in the Post-IndigoCarmine Era: A Randomized Controlled Trial. Many gynecologic, urologic, and pelvic reconstructive surgeries require accurate intraoperative evaluation of ureteral patency. We performed a randomized controlled trial to compare surgeon satisfaction with 4 methods of evaluating ureteral patency during cystoscopy at the time of benign gynecologic
Magnified endoscopic observation of small depressed gastric lesions using linked color imaging with indigocarmine dye. Magnifying linked color imaging with indigocarmine dye (M-Chromo-LCI) enables sterically enhanced and color image-magnified observation of the superficial gastric mucosa. This study investigated the usefulness of M-Chromo-LCI for the differential diagnosis of gastric lesions
Flexible spectral imaging color enhancement and indigocarmine in neoplasia diagnosis during colonoscopy: a large prospective UK series Flexible spectral imaging color enhancement and indigocarmine in neoplasia diagnosis during colonoscopy: a large prospective UK series ..
Impact of IndigoCarmine Pump Spraying on the Adenoma Detection Rate Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigocarmine spraying up to the colonic mucosa could probably increase the adenoma detection rate. The traditional method of dye spraying with spraying catheter or syringe would consume a lot of time and dye volume. Now , the more convenient auxiliary water supply channel can be used to spray indigocarmine. In order to explore the clinical application value of spraying indigocarmine solution by auxiliary water channel in high-risk population, we performed a prospective, randomized controlled trial to compare adenoma detection rate of conventional colonoscopy and chromoendoscopy. If patients scheduled for colonoscopy
Useful condition of chromoendoscopy with indigocarmine and acetic acid for identifying a demarcation line prior to endoscopic submucosal dissection for early gastric cancer. Identifying a precise demarcation line (DL) is indispensable for pathological complete en bloc endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). We evaluated the useful condition of chromoendoscopy with indigocarmine and acetic acid for marking dots around lesions before ESD for EGC. We examined 98 consecutive patients with 109 intramucosal EGCs (mean diameter, 17.8 ± 12.4 mm; main histologic type, 96 intestinal and 13 diffuse) resected by en bloc ESD after chromoendoscopy with indigocarmine and acetic acid between December 2012 and February 2014. The DL was identified by this technique just before
Severe Hypotension, Hypoxia, and Subcutaneous Erythema Induced by IndigoCarmine Administration during Open Prostatectomy Indigocarmine (also known as 5,5'-indigodisulfonic acid sodium salt or indigotine) is a blue dye that is administered intravenously to examine the urinary tract and usually is biologically safe and inert. Indigocarmine rarely may cause adverse reactions. We treated a 66-year -old man who had general anesthesia and radical retropubic prostatectomy for prostate cancer. He had a previous history of allergy to bee sting with nausea, vomiting, and dizziness. Within 1 minute after injection of indigocarmine for evaluation of the ureters, the patient developed hypotension to 40 mmHg, severe hypoxia (the value of SpO2 (peripheral capillary oxygen saturation) was 75% on 40