A case of karyomegalic interstitialnephritis without FAN1 mutations in the setting of brentuximab, ifosfamide, and carboplatin exposure. Karyomegalic interstitialnephritis (KIN) is a rare renal diagnosis associated with both genetic and medication etiologies. The primary gene associated with KIN is the FAN1 gene which encodes a protein responsible for DNA interstrand repair. Common medication , carboplatin, etoposide, all of which were discontinued due to side effects. Following an episode of acute kidney injury, the serum creatinine was 1.09 mg/dL. She then received 2 doses of brentuximab, the serum creatinine rose, and the drug was discontinued. Kidney biopsy done 2 months after brentuximab and 5 months following ifosfamide therapies showed karyomegalic interstitialnephritis. Genetic evaluation
A case of IgG4-related interstitialnephritis with ureteral obstruction: case report and literature review. IgG4-related disease (IgG4-RD) is a newly discovered systemic disease that can affect any organ or tissue in the body. IgG4-related kidney disease (IgG4-RKD) is relatively rare but essential to IgG4-RD. However, there are few reports of IgG4-RD mimicking malignant ureteral tumors leading extensive infiltration of IgG4-positive plasma cells in renal interstitium, which was diagnosed as IgG4-associated tubule-interstitialnephritis(IgG4-TIN). The renal function improved significantly after double-J tube implantation of the right ureter and moderate-dose hormone therapy. The serum IgG4 decreased to the normal range, and the right lower ureter mass almost disappeared after one year of low
Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitialnephritis. BackgroundAcute tubulointerstitial nephritis (AIN) is one of the few causes of acute kidney injury with diagnosis-specific treatment options. However, due to the need to obtain a kidney biopsy for histological confirmation, AIN diagnosis can be delayed, missed, or incorrectly assumed. Here
A low BUN/creatinine ratio predicts histologically confirmed acute interstitialnephritis. In hospitalized patients with acute renal injury (AKI), acute tubulointerstitial nephritis (AIN) constitutes one of the leading etiologies. The objective of this study was to identify clinical and biochemical variables in patients with AKI associated with kidney biopsy-confirmed AIN. For our prospective
Randomized control trial of prednisolone and doxycycline in patients with acute interstitialnephritis of unknown aetiology. Patients presenting with acute interstitialnephritis (AIN) of unknown aetiology, probably the earliest presentation of chronic kidney disease of unknown aetiology (CKDu), have been treated with oral prednisolone and doxycycline by physicians in Sri Lanka. This trial
Systemic sarcoidosis presenting as a rare combination of interstitialnephritis with necrotizing vasculitis and urinary retention due to prostate involvement: a case report. Sarcoidosis affects multiple organs and exhibits diverse clinical manifestations. Although tubulointerstitial nephritis is a known feature of renal involvement, necrotizing vasculitis is rare. Furthermore, prostate
Renal tubular acidosis without interstitialnephritis in Sjögren's syndrome: a case report and review of the literature. Renal tubular acidosis is the principal clinical feature associated with tubulointerstitial nephritis in patients with primary Sjögren's syndrome. Renal tubular dysfunction due to interstitialnephritis has been considered the underlying pathophysiology connecting renal renal tubular acidosis with primary Sjögren's syndrome. This diagnosis was based on a positive Schirmer's test. Besides, anti-Sjögren's syndrome-related antigen A was also detected. Laboratory tests indicated distal RTA; however, a renal biopsy showed no obvious interstitialnephritis. Laboratory tests conducted during the second admission indicated distal renal tubular acidosis. Therefore, a renal
Chronic InterstitialNephritis in Agricultural Communities: Observational and Mechanistic Evidence Supporting the Role of Nephrotoxic Agrochemicals. Chronic interstitialnephritis in agricultural communities (CINAC) is an epidemic of kidney disease affecting specific tropical and subtropical regions worldwide and is characterized by progressive chronic kidney disease (CKD) in the absence
Karyomegalic interstitialnephritis as a rare cause of kidney graft dysfunction: case report and review of literature. Karyomegalic interstitialnephritis (KIN) is a rare cause of chronic interstitialnephritis characterized by enlarged renal tubular epithelial nuclei. The first case of KIN reported in a kidney graft was in 2019. Here, we report the first case of KIN in 2 brothers receiving
Cefiderocol treatment of Pseudomonas aeruginosa and extensively drug-resistant Acinetobacter baumannii retained spinal hardware infection causing reversible acute interstitialnephritis: Recto: Cefiderocol causing acute interstitialnephritis. Infections with extensively drug-resistant Acinetobacter baumannii (XDRAB) have limited therapeutic options. We report successful salvage treatment of XDRAB and Pseudomonas aeruginosa-infected retained spinal hardware with cefiderocol, despite the development of reversible acute interstitialnephritis after 32 days of treatment.
Tertiary lymphoid structure signatures are associated with immune checkpoint inhibitor related acute interstitialnephritis. Tertiary lymphoid structures (TLSs) are associated with anti-tumor response following immune checkpoint inhibitor (ICI) therapy, but a commensurate observation of TLS is absent for immune related adverse events (irAEs) i.e. acute interstitialnephritis (AIN). We
Granulomatous interstitialnephritis with CTLA-4 haploinsufficiency: a case report. Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential inhibitory regulator of immune activation. CTLA-4 haploinsufficiency is known to be associated with dysregulation of FOXP3 regulatory T cells, hyperactivation of effector T cells, and lymphocytic infiltration of multiple organs. However, there have only
Prednisolone treatment in acute interstitialnephritis (PRAISE) - protocol for the randomized controlled trial. Acute interstitialnephritis (AIN) is an important and common cause of acute renal failure. There are no generally accepted guidelines for the treatment of AIN, due to the lack of prospective randomized trials. Since AIN is characterized by an enhanced immune response
Primary Sjögren syndrome-associated acute interstitialnephritis and type 3 renal tubular acidosis in a patient with thin basement membrane nephropathy: A case report. The kidney is one of the common extraglandular sites involved in primary Sjögren syndrome (pSS), with chronic tubulointerstitial nephritis (TIN) the most common pathology type. Renal involvement in pSS often presents as chronic
Karyomegalic interstitialnephritis with a novel FAN1 gene mutation and concurrent ALECT2 amyloidosis. Karyomegalic interstitialnephritis (KIN) is a rare hereditary cause of chronic kidney disease. It typically causes progressive renal impairment with haemoproteinuria requiring renal replacement therapy before 50 years of age. It has been associated with mutations in the Fanconi anaemia
Predicting outcome in acute interstitialnephritis: a case-series examining the importance of histological parameters. The clinical significance of common histological parameters in acute interstitialnephritis (AIN) is uncertain. We aimed to evaluate the utility of histology in predicting clinical outcomes in patients with AIN. Adult renal biopsies yielding a diagnosis of AIN between 2000
Chronic InterstitialNephritis in Agricultural Communities (CINAC) in Sri Lanka. A significant increase in cases of chronic kidney disease has been observed in the dry zone of Sri Lanka. This unusual chronic kidney disease was first reported in the early 1990s among middle-aged paddy farmers. Considering epidemiologic and histopathologic findings, the disease recently was named chronic interstitialnephritis in agricultural communities (CINAC). Twenty-five years after the first report, CINAC is the most significant public health issue in the paddy farming areas with more than 70,000 estimated patients and many deaths. Histopathologically, this disease is a tubular interstitialnephritis associated with glomerular sclerosis and mild vascular changes. Morphologic and biochemical
Severe acute interstitialnephritis induced by valsartan: A case report. Angiotensin receptor blocker (ARB) can increase serum creatinine or potassium levels in patients with renal insufficiency, renal artery stenosis, heart failure or hypovolemia, but hardly cause severe kidney injury in patients without any risk factors. A case of severe acute interstitialnephritis (AIN) induced by valsartan
Acute interstitialnephritis with podocyte foot-process effacement complicating Plasmodium falciparum infection. Malarial acute renal failure (MARF) is a component of the severe malaria syndrome, and complicates 1-5% of malaria infections. This form of renal failure has not been well characterized by histopathology. A 44 year-old male presented to the emergency department with a 5-day history of fever and malaise after returning from Nigeria. A blood film was positive for Plasmodium falciparum. His creatinine was 616 µmol/L coming from a normal baseline of 89 µmol/L. He had a urine protein:creatinine ratio of 346 mg/mmol (4.4 g/L). He required dialysis. A renal biopsy showed acute interstitialnephritis with podocyte foot-process effacement. He was treated with artesunate and his renal